ID   CEP2_HHV7J              Reviewed;         330 AA.
AC   P52359;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 62.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=U65;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC       nucleus up to 18 hours postinfection, but at later times localizes to
CC       punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; U43400; AAC54727.1; -; Genomic_DNA.
DR   PIR; T41967; T41967.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..330
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000115951"
SQ   SEQUENCE   330 AA;  37498 MW;  FF32C19CEBF05901 CRC64;
     MNFSSIGNLG CLRSFLQNEC NWFSVCKKKL YHEYRCVATS SPVFAVDKFK DCLHCNIIIL
     KKNLDFVFSL AINGIHAGQF ATNSIKLKKI IITNDLVYYI LELGSLTVTD LHFIPKYNSE
     HVLNVRPITP NLIYDTCSIV SYDEAKLLTV KGPGENKLIP LGCGSWCLNN MGRYYVYTFV
     LVYDLYLACF EKNTLPSLSK VVFDMISCNN KHCVFCKDHS KHVEQTGKTV GCTDNQETCF
     CYTPCKKKMA KISNQDLSSL LCDQELDLLD LIYPEKPTSL STDINAYVHG HKNQEPVVLR
     NTNWILIRLD PAISRLILLS CPVCKRIVSR