ID   CEP2_HHV8P              Reviewed;         334 AA.
AC   F5HEF2;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   29-SEP-2021, entry version 26.
DE   RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN   Name=ORF33;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   VIRION.
RX   PubMed=15613308; DOI=10.1128/jvi.79.2.800-811.2005;
RA   Zhu F.X., Chong J.M., Wu L., Yuan Y.;
RT   "Virion proteins of Kaposi's sarcoma-associated herpesvirus.";
RL   J. Virol. 79:800-811(2005).
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-Rule:MF_04039,
CC       ECO:0000269|PubMed:15613308}. Host cytoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_04039}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04039}.
CC       Note=Localizes in the host nucleus up to 18 hours postinfection, but at
CC       later times localizes to punctate, cytoplasmic structures.
CC       {ECO:0000255|HAMAP-Rule:MF_04039}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR   EMBL; AF148805; ABD28884.1; -; Genomic_DNA.
DR   RefSeq; YP_001129386.1; NC_009333.1.
DR   PRIDE; F5HEF2; -.
DR   GeneID; 4961502; -.
DR   KEGG; vg:4961502; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IDA:CACAO.
DR   HAMAP; MF_04039; HSV_CEP2; 1.
DR   InterPro; IPR004286; Herpes_UL16/UL94.
DR   Pfam; PF03044; Herpes_UL16; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW   Virion tegument.
FT   CHAIN           1..334
FT                   /note="Cytoplasmic envelopment protein 2"
FT                   /id="PRO_0000423764"
SQ   SEQUENCE   334 AA;  36732 MW;  2B7F1CC59A6D378D CRC64;
     MASRRRKLRN FLNKECIWTV NPMSGDHIKV FNACTSISPV YDPELVTSYA LSVPAYNVSV
     AILLHKVMGP CVAVGINGEM IMYVVSQCVS VRPVPGRDGM ALIYFGQFLE EASGLRFPYI
     APPPSREHVP DLTRQELVHT SQVVRRGDLT NCTMGLEFRN VNPFVWLGGG SVWLLFLGVD
     YMAFCPGVDG MPSLARVAAL LTRCDHPDCV HCHGLRGHVN VFRGYCSAQS PGLSNICPCI
     KSCGTGNGVT RVTGNRNFLG LLFDPIVQSR VTALKITSHP TPTHVENVLT GVLDDGTLVP
     SSKAPWVLLR MSDYFSRLLI YECKKLKALG LRSY