CEP2_PSHV1
ID CEP2_PSHV1 Reviewed; 355 AA.
AC Q6UDI0;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 02-DEC-2020, entry version 38.
DE RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN Name=UL16;
OS Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS (Pacheco's disease virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX NCBI_TaxID=670426;
OH NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA Thureen D.R., Keeler C.L. Jr.;
RT "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL J. Virol. 80:7863-7872(2006).
CC -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC Participates in the final step of tegumentation and envelope
CC acquisition within the host cytoplasm by directly interacting with the
CC capsid. Upon virion binding to target cell, a signaling cascade is
CC triggered to disrupt the interaction with the capsid, thereby preparing
CC capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC nucleus up to 18 hours postinfection, but at later times localizes to
CC punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR EMBL; AY372243; AAQ73730.1; -; Genomic_DNA.
DR RefSeq; NP_944424.1; NC_005264.1.
DR PRIDE; Q6UDI0; -.
DR GeneID; 2657009; -.
DR KEGG; vg:2657009; -.
DR Proteomes; UP000006840; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR HAMAP; MF_04039; HSV_CEP2; 1.
DR InterPro; IPR004286; Herpes_UL16/UL94.
DR Pfam; PF03044; Herpes_UL16; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW Virion tegument.
FT CHAIN 1..355
FT /note="Cytoplasmic envelopment protein 2"
FT /id="PRO_0000406845"
SQ SEQUENCE 355 AA; 39826 MW; CCD3F57602CBE247 CRC64;
MRVSVSKIGT SCAERLLNDV NVWARVRNDP LLTILTAKMP LRKEYRRWFD GIEEDKPAAG
ADTSSLRIYL YLTKPKRSRG GRRNVHITAV VNGAHAFCLL SRMGAEKSPL GGETFCIRVS
KSKLCPTPLE DLPDPRNEPV PSQILPADYT SLTSKAIPPL DPEWCVCLSP GAWWHYPTET
VFFFHLKDIM KSICPAGWNS MTFCAILTAF LDPKPRNCDL RRDTRRRHVD QFGNTDGPGA
ELFCPCKVPC HNEDGPRRTP LRPRGEQNLL KLLFVGHVET VTQLQHACEP GYIPGDVSRV
IRGNGADGRR VPPNCQAWDL LKFTQFASRS LLCGCPEMRR IVDDAADSSW LRSGE