CEP2_SHV21
ID CEP2_SHV21 Reviewed; 330 AA.
AC Q01022;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 02-DEC-2020, entry version 53.
DE RecName: Full=Cytoplasmic envelopment protein 2 {ECO:0000255|HAMAP-Rule:MF_04039};
GN Name=33;
OS Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX NCBI_TaxID=10383;
OH NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=1321287; DOI=10.1128/jvi.66.8.5047-5058.1992;
RA Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B.,
RA Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B.,
RA Honess R.W.;
RT "Primary structure of the herpesvirus saimiri genome.";
RL J. Virol. 66:5047-5058(1992).
CC -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC Participates in the final step of tegumentation and envelope
CC acquisition within the host cytoplasm by directly interacting with the
CC capsid. Upon virion binding to target cell, a signaling cascade is
CC triggered to disrupt the interaction with the capsid, thereby preparing
CC capsid uncoating. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC capsid. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC Rule:MF_04039}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04039}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04039}. Note=Localizes in the host
CC nucleus up to 18 hours postinfection, but at later times localizes to
CC punctate, cytoplasmic structures. {ECO:0000255|HAMAP-Rule:MF_04039}.
CC -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC protein 2 family. {ECO:0000255|HAMAP-Rule:MF_04039}.
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DR EMBL; X64346; CAA45655.1; -; Genomic_DNA.
DR RefSeq; NP_040235.1; NC_001350.1.
DR PRIDE; Q01022; -.
DR GeneID; 1682463; -.
DR KEGG; vg:1682463; -.
DR Proteomes; UP000000587; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR HAMAP; MF_04039; HSV_CEP2; 1.
DR InterPro; IPR004286; Herpes_UL16/UL94.
DR Pfam; PF03044; Herpes_UL16; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion;
KW Virion tegument.
FT CHAIN 1..330
FT /note="Cytoplasmic envelopment protein 2"
FT /id="PRO_0000115956"
SQ SEQUENCE 330 AA; 36993 MW; D1FAE6C0AEA45159 CRC64;
MDDFRNKLRN FLNNECLWVK NVACTSFTKV YCATTAVSPF FKPISPQGVP DKHYINVTLI
ILKPKKSHPY ITVYINDLAV DCCSTEILQV KPVPCSHFSL IYFGPLIAPP HNVQIPANLS
IKASKKSHLT KNQVIFTSKV IHPERLPDGY KSASLIGACA WYSEGAIFQH FLSTDYMSLC
PAFKEFPSLS RILSLLTRCD DLSCVPCYGE KIHVNCQSGY TDSDCDGKSN SCPCITSCTA
LKKDIVPITG HRNLLSLLFD ATIQHNITSI KFFSPQTPTT VNNVFCGVLD TGETVECTCE
AWNLLMFSDF ISRQMIYNCQ IMKRFCLRSC