ID   CEP41_CHICK             Reviewed;         367 AA.
AC   E1C065;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Centrosomal protein of 41 kDa;
DE            Short=Cep41;
GN   Name=CEP41;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl;
RX   PubMed=15592404; DOI=10.1038/nature03154;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA   Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA   Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA   Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA   McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA   Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA   Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA   Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA   Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA   Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA   Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA   Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA   Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA   Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA   Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA   Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA   Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA   Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA   Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA   Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA   Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA   Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA   Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA   Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA   Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA   Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA   Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA   Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide unique
RT   perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
CC   -!- FUNCTION: Required during ciliogenesis for tubulin glutamylation in
CC       cilium. Probably acts by participating in the transport of tubulin
CC       polyglutamylases between the basal body and the cilium (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cell projection, cilium
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Note=Localizes mainly to the cilium basal body and in
CC       primary cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CEP41 family. {ECO:0000305}.
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DR   EMBL; AADN02039802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001186322.1; NM_001199393.1.
DR   AlphaFoldDB; E1C065; -.
DR   SMR; E1C065; -.
DR   STRING; 9031.ENSGALP00000013137; -.
DR   PaxDb; E1C065; -.
DR   PRIDE; E1C065; -.
DR   Ensembl; ENSGALT00000013152; ENSGALP00000013137; ENSGALG00000008103.
DR   GeneID; 416684; -.
DR   KEGG; gga:416684; -.
DR   CTD; 95681; -.
DR   VEuPathDB; HostDB:geneid_416684; -.
DR   eggNOG; ENOG502QR8A; Eukaryota.
DR   GeneTree; ENSGT00390000002222; -.
DR   HOGENOM; CLU_064316_0_0_1; -.
DR   InParanoid; E1C065; -.
DR   OMA; DRCHIIS; -.
DR   OrthoDB; 1216222at2759; -.
DR   PhylomeDB; E1C065; -.
DR   TreeFam; TF324682; -.
DR   Reactome; R-GGA-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-GGA-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-GGA-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-GGA-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-GGA-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-GGA-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-GGA-8854518; AURKA Activation by TPX2.
DR   PRO; PR:E1C065; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000008103; Expressed in testis and 13 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.250.10; -; 1.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   Pfam; PF00581; Rhodanese; 1.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   3: Inferred from homology;
KW   Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation;
KW   Cytoplasm; Cytoskeleton; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..367
FT                   /note="Centrosomal protein of 41 kDa"
FT                   /id="PRO_0000416266"
FT   DOMAIN          169..266
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT   REGION          89..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   367 AA;  40628 MW;  856FF3AE7326B599 CRC64;
     MSSRRSVGDP EYLTRRIPQN PRYQHIKTRL DTGSSLTKYI EKLEEIKRNY RYRKDELFKR
     LKVTTFAQLV VQVASLSDET LEVTNEEIHK LEGGNSPASD ADAELTAGTN GKGSPNGTPP
     SPVLFINNAG AGESYRSTLQ SLISGVGELD IEKDTHKKAD TQAKDTPYPD CPFLLLDVRD
     RDAYDQCHIV GAYSYPIAML SRAMNPYTNS ILEYKNAHGK IIILYDDDER LASQAATTMC
     ERGFENLFML SGGLKVLAQK VPEGLITGSL PISCQVAAPT GSARKKPVPK VPPTRAESKW
     RYSAEDLQKI KYYLEEEQLP SDTASRLSRG SSGRDSKATT ARSSPSLPST AGSRMLSRSS
     IQNRPWK