CEP41_XENTR
ID CEP41_XENTR Reviewed; 365 AA.
AC Q28FA8; F6S799;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Centrosomal protein of 41 kDa;
DE Short=Cep41;
DE AltName: Full=Testis-specific gene A14 protein;
GN Name=cep41; Synonyms=tsga14; ORFNames=TEgg077h17.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required during ciliogenesis for tubulin glutamylation in
CC cilium. Probably acts by participating in the transport of tubulin
CC polyglutamylases between the basal body and the cilium (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Cell projection, cilium
CC {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250}. Note=Localizes mainly to the cilium basal body and in
CC primary cilia. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CEP41 family. {ECO:0000305}.
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DR EMBL; CR762062; CAJ81928.1; -; mRNA.
DR EMBL; AAMC01005674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01005675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01005676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC158166; AAI58167.1; -; mRNA.
DR RefSeq; NP_001016937.1; NM_001016937.2.
DR AlphaFoldDB; Q28FA8; -.
DR SMR; Q28FA8; -.
DR STRING; 8364.ENSXETP00000054787; -.
DR PaxDb; Q28FA8; -.
DR GeneID; 549691; -.
DR KEGG; xtr:549691; -.
DR CTD; 95681; -.
DR Xenbase; XB-GENE-980648; cep41.
DR eggNOG; ENOG502QR8A; Eukaryota.
DR InParanoid; Q28FA8; -.
DR OrthoDB; 1216222at2759; -.
DR Reactome; R-XTR-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-XTR-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-XTR-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-XTR-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-XTR-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-XTR-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-XTR-8854518; AURKA Activation by TPX2.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.250.10; -; 1.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR Pfam; PF00581; Rhodanese; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52821; SSF52821; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation;
KW Cytoplasm; Cytoskeleton; Protein transport; Reference proteome; Transport.
FT CHAIN 1..365
FT /note="Centrosomal protein of 41 kDa"
FT /id="PRO_0000416270"
FT DOMAIN 177..274
FT /note="Rhodanese"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT REGION 327..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 41198 MW; 80F1A34847C82921 CRC64;
MSAKRSIGDS EILKKRIPQN LKYQHIKTRL DTGNSMTKYL EKIEEIKKNY RYKKDELFKR
IKVTTFAQLV LQVASVSEER ESGEMTTDEL QRLEDNSSVI SDTEFLTDRT NGKGSPVNDS
KSPIQFIDSE RGEECIHTSR STLQSVISGV GELDLGNQAD KKKESLQSSS ALDKPYEDCP
FLLLDVRDRD SYDQCHVVGA KNYPVAMLSR TMNPFTPEIL EYRNAHGKII ILYDEDERIA
SQAATTMCER GFENLFMLSG GLKVISQKFP QGLTTGSFPV TCLVPPTQMK SALKRTPKDP
IVPAEDKWRF SSQDLEMIEN HLENMLMSTS TPSRLRMDSR NSKVPSSASS ARSQSSTSSH
SKPWK