ID   CEP44_MACFA             Reviewed;         390 AA.
AC   Q4R7I0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Centrosomal protein of 44 kDa;
DE            Short=Cep44;
GN   Name=CEP44; ORFNames=QtsA-15204;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centriole-enriched microtubule-binding protein involved in
CC       centriole biogenesis. In collaboration with CEP295 and POC1B, is
CC       required for the centriole-to-centrosome conversion by ensuring the
CC       formation of bona fide centriole wall. Functions as a linker component
CC       that maintains centrosome cohesion. Associates with CROCC and regulates
CC       its stability and localization to the centrosome.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
CC   -!- SUBUNIT: Interacts with CROCC. Interacts with POC1B; the interaction is
CC       direct and recruits POC1B to centriolar microtubules. Binds to
CC       centriolar microtubules. {ECO:0000250|UniProtKB:Q9C0F1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q9C0F1}. Midbody {ECO:0000250|UniProtKB:Q9C0F1}.
CC       Note=Localizes to the proximal end of mother and daughter centrioles.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB168838; BAE00942.1; -; mRNA.
DR   RefSeq; NP_001271681.1; NM_001284752.1.
DR   AlphaFoldDB; Q4R7I0; -.
DR   SMR; Q4R7I0; -.
DR   STRING; 9541.XP_005556374.1; -.
DR   GeneID; 101865133; -.
DR   CTD; 80817; -.
DR   eggNOG; ENOG502R3RQ; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   GO; GO:0010457; P:centriole-centriole cohesion; ISS:UniProtKB.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   InterPro; IPR033603; CEP44.
DR   InterPro; IPR029157; CEP44_CC.
DR   PANTHER; PTHR31477; PTHR31477; 2.
DR   Pfam; PF15007; CEP44; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..390
FT                   /note="Centrosomal protein of 44 kDa"
FT                   /id="PRO_0000293723"
FT   REGION          11..195
FT                   /note="Binds with microtubules and centrioles"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0F1"
FT   REGION          323..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          233..267
FT                   /evidence="ECO:0000255"
FT   COILED          361..385
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        333..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         331
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0F1"
FT   MOD_RES         345
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0F1"
FT   MOD_RES         346
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0F1"
SQ   SEQUENCE   390 AA;  44162 MW;  88CF848C48AE4522 CRC64;
     MATGDLKRSL RNLEQVLRLL NYPEEVDCVG LIKGDPAASL PIISYSFTSY SPYVTELIME
     SNVELIAKND LRFIDAVYKL LRDQFNYKPI LTKKQFIQCG FAEWKIQIVC DILNCVMKKH
     KELSSLQKIP SQQRKKISSG KSEPSLSNEK ISAEAVGVDT SGRFVTSGKK KAVVIRHLYN
     EDNVEISEDT LSPITGVNEA VDVSDLNATE IKMPEVKVPE IKAEQQDINV NPEITALQTM
     LAECQEKLKE LTLIEKRLDC LEQKMKGNVM VDENTWTNLL SRVTLLETEM LLSKKNDEYV
     EFNEINEDCA SCSNMDLLNP HRKNKVGRPA SIPLSSRYST ASSDSTPRAS TINYCGLNEI
     SEETTIQKME RMKKMFEETA ELLKCPNHYL