CEP44_MOUSE
ID CEP44_MOUSE Reviewed; 386 AA.
AC Q5HZK1; Q5DTV5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Centrosomal protein of 44 kDa;
DE Short=Cep44;
GN Name=Cep44; Synonyms=Kiaa1712;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Centriole-enriched microtubule-binding protein involved in
CC centriole biogenesis. In collaboration with CEP295 and POC1B, is
CC required for the centriole-to-centrosome conversion by ensuring the
CC formation of bona fide centriole wall. Functions as a linker component
CC that maintains centrosome cohesion. Associates with CROCC and regulates
CC its stability and localization to the centrosome.
CC {ECO:0000250|UniProtKB:Q9C0F1}.
CC -!- SUBUNIT: Interacts with CROCC. Interacts with POC1B; the interaction is
CC direct and recruits POC1B to centriolar microtubules. Binds to
CC centriolar microtubules. {ECO:0000250|UniProtKB:Q9C0F1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250|UniProtKB:Q9C0F1}. Midbody {ECO:0000250|UniProtKB:Q9C0F1}.
CC Note=Localizes to the proximal end of mother and daughter centrioles.
CC {ECO:0000250|UniProtKB:Q9C0F1}.
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DR EMBL; AK220415; BAD90461.1; -; mRNA.
DR EMBL; BC088983; AAH88983.1; -; mRNA.
DR CCDS; CCDS22313.1; -.
DR RefSeq; NP_001009951.1; NM_001009951.1.
DR RefSeq; XP_006509508.1; XM_006509445.3.
DR RefSeq; XP_006509509.1; XM_006509446.3.
DR RefSeq; XP_006509510.1; XM_006509447.3.
DR RefSeq; XP_006509511.1; XM_006509448.3.
DR RefSeq; XP_006509512.1; XM_006509449.3.
DR RefSeq; XP_006509513.1; XM_006509450.3.
DR RefSeq; XP_006509514.1; XM_006509451.3.
DR RefSeq; XP_006509515.1; XM_006509452.3.
DR RefSeq; XP_017168359.1; XM_017312870.1.
DR AlphaFoldDB; Q5HZK1; -.
DR SMR; Q5HZK1; -.
DR BioGRID; 238188; 14.
DR IntAct; Q5HZK1; 14.
DR STRING; 10090.ENSMUSP00000042586; -.
DR PhosphoSitePlus; Q5HZK1; -.
DR EPD; Q5HZK1; -.
DR MaxQB; Q5HZK1; -.
DR PaxDb; Q5HZK1; -.
DR PRIDE; Q5HZK1; -.
DR ProteomicsDB; 280068; -.
DR Antibodypedia; 50770; 115 antibodies from 22 providers.
DR DNASU; 382010; -.
DR Ensembl; ENSMUST00000040330; ENSMUSP00000042586; ENSMUSG00000038215.
DR GeneID; 382010; -.
DR KEGG; mmu:382010; -.
DR UCSC; uc009lsp.1; mouse.
DR CTD; 80817; -.
DR MGI; MGI:3525111; Cep44.
DR VEuPathDB; HostDB:ENSMUSG00000038215; -.
DR eggNOG; ENOG502R3RQ; Eukaryota.
DR GeneTree; ENSGT00390000009873; -.
DR HOGENOM; CLU_060541_0_0_1; -.
DR InParanoid; Q5HZK1; -.
DR OMA; YCGLKEN; -.
DR OrthoDB; 1589624at2759; -.
DR PhylomeDB; Q5HZK1; -.
DR TreeFam; TF332994; -.
DR BioGRID-ORCS; 382010; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Cep44; mouse.
DR PRO; PR:Q5HZK1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q5HZK1; protein.
DR Bgee; ENSMUSG00000038215; Expressed in spermatocyte and 234 other tissues.
DR ExpressionAtlas; Q5HZK1; baseline and differential.
DR Genevisible; Q5HZK1; MM.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR GO; GO:0010457; P:centriole-centriole cohesion; ISS:UniProtKB.
DR GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR InterPro; IPR033603; CEP44.
DR InterPro; IPR029157; CEP44_CC.
DR PANTHER; PTHR31477; PTHR31477; 2.
DR Pfam; PF15007; CEP44; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..386
FT /note="Centrosomal protein of 44 kDa"
FT /id="PRO_0000293724"
FT REGION 11..194
FT /note="Binds with microtubules and centrioles"
FT /evidence="ECO:0000250|UniProtKB:Q9C0F1"
FT COILED 232..263
FT /evidence="ECO:0000255"
FT COILED 359..383
FT /evidence="ECO:0000255"
FT CONFLICT 55
FT /note="A -> V (in Ref. 1; BAD90461)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="D -> E (in Ref. 1; BAD90461)"
FT /evidence="ECO:0000305"
FT CONFLICT 341
FT /note="S -> A (in Ref. 1; BAD90461)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 386 AA; 43255 MW; B14F7F770F5ABF84 CRC64;
MATGDLKRSL RKLEQVLRSL NYPNEVDYVG LIKGDTAASL PIISYSLTSY SPYVAELLME
SSIELIAKND VRFTDTVYKL LRDQFDYKPI LTKKQFIQSG FAEWKIEIVC DILNCVMKKH
KELIGLDKNS SCQRKKNVSE KPEPCSNSEK RPAEAVGIDI TGRFMTSGKK KAVVIRHLYT
DEKVGVPEGT VTLADISQGC SESAEQSSDI RIPEAQDPEV KAELQDICDH PEITALQIAL
AECQEKLKQL TWIEKRLERL EAATHGKVMV DEKAWNNLLS RVTLLETEML LSKKSESVER
NVASQDCESI SDVDFVPYDK NYSVGGAAGN YRSSGCSAVS SETAPGSSIV NYCVLREFSE
ETTIQKMERM KKMFEETAEL LKCSSR
