ID   CEP44_RAT               Reviewed;         386 AA.
AC   Q3B7T8;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Centrosomal protein of 44 kDa;
DE            Short=Cep44;
GN   Name=Cep44;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Centriole-enriched microtubule-binding protein involved in
CC       centriole biogenesis. In collaboration with CEP295 and POC1B, is
CC       required for the centriole-to-centrosome conversion by ensuring the
CC       formation of bona fide centriole wall. Functions as a linker component
CC       that maintains centrosome cohesion. Associates with CROCC and regulates
CC       its stability and localization to the centrosome.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
CC   -!- SUBUNIT: Interacts with CROCC. Interacts with POC1B; the interaction is
CC       direct and recruits POC1B to centriolar microtubules. Binds to
CC       centriolar microtubules. {ECO:0000250|UniProtKB:Q9C0F1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q9C0F1}. Midbody {ECO:0000250|UniProtKB:Q9C0F1}.
CC       Note=Localizes to the proximal end of mother and daughter centrioles.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
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DR   EMBL; BC107470; AAI07471.1; -; mRNA.
DR   RefSeq; NP_001032258.1; NM_001037181.1.
DR   RefSeq; XP_006253149.1; XM_006253087.3.
DR   AlphaFoldDB; Q3B7T8; -.
DR   SMR; Q3B7T8; -.
DR   BioGRID; 253300; 1.
DR   STRING; 10116.ENSRNOP00000014083; -.
DR   PaxDb; Q3B7T8; -.
DR   PRIDE; Q3B7T8; -.
DR   Ensembl; ENSRNOT00000014083; ENSRNOP00000014083; ENSRNOG00000010566.
DR   GeneID; 290722; -.
DR   KEGG; rno:290722; -.
DR   UCSC; RGD:1308517; rat.
DR   CTD; 80817; -.
DR   RGD; 1308517; Cep44.
DR   eggNOG; ENOG502R3RQ; Eukaryota.
DR   GeneTree; ENSGT00390000009873; -.
DR   HOGENOM; CLU_060541_0_0_1; -.
DR   InParanoid; Q3B7T8; -.
DR   OMA; YCGLKEN; -.
DR   OrthoDB; 1589624at2759; -.
DR   PhylomeDB; Q3B7T8; -.
DR   TreeFam; TF332994; -.
DR   PRO; PR:Q3B7T8; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000010566; Expressed in ovary and 19 other tissues.
DR   Genevisible; Q3B7T8; RN.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   GO; GO:0010457; P:centriole-centriole cohesion; ISS:UniProtKB.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   InterPro; IPR033603; CEP44.
DR   InterPro; IPR029157; CEP44_CC.
DR   PANTHER; PTHR31477; PTHR31477; 2.
DR   Pfam; PF15007; CEP44; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..386
FT                   /note="Centrosomal protein of 44 kDa"
FT                   /id="PRO_0000293725"
FT   REGION          11..194
FT                   /note="Binds with microtubules and centrioles"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0F1"
FT   COILED          232..262
FT                   /evidence="ECO:0000255"
FT   COILED          359..382
FT                   /evidence="ECO:0000255"
FT   MOD_RES         329
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0F1"
SQ   SEQUENCE   386 AA;  43266 MW;  517FB8DB2DEEE605 CRC64;
     MATGDLKRSL RKLEQVLRSL NYPNEVDYVG LMKGDTAASL PIISYSLTSY SPHVAELLME
     SNIELIAKND VRFTDTVYKL LRDQFDYKPI LTKKQFIQSG FAEWKIEIVC DILNCVMKKH
     KKLIGLDKNS SCQRKKSISE KPEPCSSREK CPAEAVGIDV TGRFMTSGKK KAVVIRHLYT
     EENVGVPEGT VTSTEVSEGC DELEEQSSDI RIPEAQAPEV KAELQDMCDN PELTALQIAL
     AECQEKLKKL TWIEKRLECL EATTKGKVMV DEKAWNNILS RVTLLETEML LSKKNESVEP
     NTTSEDSESV SGVDVVPYDK KYSVEGPAST CHSSGYSTVS SATVPRSSTI NYCGLNNFSE
     ETTMQKMERM KKMFEETAEL LKCSSR