ID   CEP44_XENLA             Reviewed;         384 AA.
AC   A2RVA7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Centrosomal protein of 44 kDa;
DE            Short=Cep44;
GN   Name=cep44;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centriole-enriched microtubule-binding protein involved in
CC       centriole biogenesis. In collaboration with CEP295 and POC1B, is
CC       required for the centriole-to-centrosome conversion by ensuring the
CC       formation of bona fide centriole wall. Functions as a linker component
CC       that maintains centrosome cohesion. Associates with CROCC and regulates
CC       its stability and localization to the centrosome.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
CC   -!- SUBUNIT: Binds to centriolar microtubules.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q9C0F1}. Midbody {ECO:0000250|UniProtKB:Q9C0F1}.
CC       Note=Localizes to the proximal end of mother and daughter centrioles.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
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DR   EMBL; BC133258; AAI33259.1; -; mRNA.
DR   RefSeq; NP_001091324.1; NM_001097855.1.
DR   AlphaFoldDB; A2RVA7; -.
DR   SMR; A2RVA7; -.
DR   GeneID; 100037156; -.
DR   KEGG; xla:100037156; -.
DR   CTD; 100037156; -.
DR   Xenbase; XB-GENE-5870211; cep44.L.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 100037156; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   GO; GO:0010457; P:centriole-centriole cohesion; ISS:UniProtKB.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   InterPro; IPR033603; CEP44.
DR   InterPro; IPR029157; CEP44_CC.
DR   PANTHER; PTHR31477; PTHR31477; 2.
DR   Pfam; PF15007; CEP44; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..384
FT                   /note="Centrosomal protein of 44 kDa"
FT                   /id="PRO_0000293726"
FT   REGION          11..188
FT                   /note="Binds with microtubules and centrioles"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0F1"
FT   REGION          191..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          221..260
FT                   /evidence="ECO:0000255"
FT   COILED          353..378
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        197..213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   384 AA;  43504 MW;  46FC14ACCA399277 CRC64;
     MATGDVKGCI RKLEQRLRTL NYPRDVDYTG LIKGDPSASL PIISYTFTCY STSIAEILIS
     FGIELTTKSD LRFIEAVYKV LRDVFNYKPI LTKQQFLQCA FSERKIQIIC DIVDCVVKKH
     KEITGQNKVK SQLVKKVVSA KDQCEVFYPE DVSVQPSVKT TQKKPLVERH AGSEFLLPTK
     CYSSALVEDI EEEEPTSDSE GGSHLEHEME SPFETAETTP NSEQIELLRK QLAECQEKLQ
     RLDCVEQRLQ SLETSMKGKI IIDETDWNNL LSRVLLLETE GLLQSKKTDF SVPSEFACIS
     EQRTSSRMTN EICSNLKTKA DIPESHHQSS GYSFVLSADT SPIAIDINYS SLTEDSNETT
     KQRMERITKM MEETSKLLKC SNNT