ID   CEP44_XENTR             Reviewed;         385 AA.
AC   Q0P4I1;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Centrosomal protein of 44 kDa;
DE            Short=Cep44;
GN   Name=cep44;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centriole-enriched microtubule-binding protein involved in
CC       centriole biogenesis. In collaboration with CEP295 and POC1B, is
CC       required for the centriole-to-centrosome conversion by ensuring the
CC       formation of bona fide centriole wall. Functions as a linker component
CC       that maintains centrosome cohesion. Associates with CROCC and regulates
CC       its stability and localization to the centrosome.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
CC   -!- SUBUNIT: Binds to centriolar microtubules.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q9C0F1}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q9C0F1}. Midbody {ECO:0000250|UniProtKB:Q9C0F1}.
CC       Note=Localizes to the proximal end of mother and daughter centrioles.
CC       {ECO:0000250|UniProtKB:Q9C0F1}.
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DR   EMBL; BC122069; AAI22070.1; -; mRNA.
DR   RefSeq; NP_001072553.1; NM_001079085.1.
DR   AlphaFoldDB; Q0P4I1; -.
DR   SMR; Q0P4I1; -.
DR   STRING; 8364.ENSXETP00000038544; -.
DR   PaxDb; Q0P4I1; -.
DR   DNASU; 780008; -.
DR   GeneID; 780008; -.
DR   KEGG; xtr:780008; -.
DR   CTD; 80817; -.
DR   Xenbase; XB-GENE-5870163; cep44.
DR   eggNOG; ENOG502R3RQ; Eukaryota.
DR   InParanoid; Q0P4I1; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   GO; GO:0010457; P:centriole-centriole cohesion; ISS:UniProtKB.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   InterPro; IPR033603; CEP44.
DR   InterPro; IPR029157; CEP44_CC.
DR   PANTHER; PTHR31477; PTHR31477; 2.
DR   Pfam; PF15007; CEP44; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..385
FT                   /note="Centrosomal protein of 44 kDa"
FT                   /id="PRO_0000293727"
FT   REGION          11..191
FT                   /note="Binds with microtubules and centrioles"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0F1"
FT   REGION          194..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          224..263
FT                   /evidence="ECO:0000255"
FT   COILED          353..379
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   385 AA;  44039 MW;  2E75531D95CF697E CRC64;
     MATGDVKGCI RKLEQRLRTL NYPRDVDYSG LIKGDPSAFL PIISYTFTCY STSIAEILIS
     LGIELATKSD LRFIEAVYKV LRDVFNYKPI LTKQQFLQCA FSERKIQIIC DIVDCVVKKH
     KEITGQNKIK NQPVKKIVSA KDQCEVFYPE DMFVQLSVKT EMSTQKKPLV ERHTGSEFQL
     QTKCYKSALL EEAEEEEPTS DCEEDSHLQR EMGSPFETAE ETPNSEQVEL LRKQLAECQE
     KLQRLDCVEE RLQSLETSVK GKIIIDETDW NNLLGRVLLL ETERLLQSKK SDLPEFARIS
     EHRTSSRMAN EICSNLKTKA DIPESHHQSS GYSSVLSADT SPIAIDINYS SLTEESKETT
     KQRMERITKM MEETSELLKF SNNTS