CEP70_HUMAN
ID CEP70_HUMAN Reviewed; 597 AA.
AC Q8NHQ1; B7Z5I8; B7Z7E8; D3DNE9; F5GZX8; Q96B31; Q9H2C3; Q9H2Z1; Q9H940;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Centrosomal protein of 70 kDa;
DE Short=Cep70;
DE AltName: Full=p10-binding protein;
GN Name=CEP70; Synonyms=BITE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Chronic myeloid leukemia cell;
RA Tschan M.P., Cajot J.-F., Grob T.J., Fey M.F., Tobler A.;
RT "Cloning and characterization of BITE: a binding partner of the cell cycle
RT inhibitor p10.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 4 AND 5), AND
RP VARIANT ASN-135.
RC TISSUE=Teratocarcinoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-135.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 3), AND
RP VARIANT ASN-135.
RC TISSUE=Skin, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Lymphoblast;
RX PubMed=14654843; DOI=10.1038/nature02166;
RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT "Proteomic characterization of the human centrosome by protein correlation
RT profiling.";
RL Nature 426:570-574(2003).
RN [7]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH TUBULIN-GAMMA.
RX PubMed=21795687; DOI=10.1074/jbc.m111.252262;
RA Shi X., Sun X., Liu M., Li D., Aneja R., Zhou J.;
RT "CEP70 protein interacts with gamma-tubulin to localize at the centrosome
RT and is critical for mitotic spindle assembly.";
RL J. Biol. Chem. 286:33401-33408(2011).
CC -!- FUNCTION: Plays a role in the organization of both preexisting and
CC nascent microtubules in interphase cells. During mitosis, required for
CC the organization and orientation of the mitotic spindle.
CC -!- SUBUNIT: Directly interacts with tubulin-gamma; this interaction
CC determines centrosomal localization. {ECO:0000269|PubMed:21795687}.
CC -!- INTERACTION:
CC Q8NHQ1; Q9ULW3: ABT1; NbExp=6; IntAct=EBI-739624, EBI-2602396;
CC Q8NHQ1; Q5U5Z8-3: AGBL2; NbExp=3; IntAct=EBI-739624, EBI-12226473;
CC Q8NHQ1; Q02040: AKAP17A; NbExp=7; IntAct=EBI-739624, EBI-1042725;
CC Q8NHQ1; Q02040-3: AKAP17A; NbExp=3; IntAct=EBI-739624, EBI-10222656;
CC Q8NHQ1; Q9NR81: ARHGEF3; NbExp=7; IntAct=EBI-739624, EBI-10312733;
CC Q8NHQ1; Q9P291: ARMCX1; NbExp=3; IntAct=EBI-739624, EBI-2843626;
CC Q8NHQ1; P48047: ATP5PO; NbExp=6; IntAct=EBI-739624, EBI-355815;
CC Q8NHQ1; A0AVN2: BARD1; NbExp=3; IntAct=EBI-739624, EBI-9977322;
CC Q8NHQ1; Q99728: BARD1; NbExp=3; IntAct=EBI-739624, EBI-473181;
CC Q8NHQ1; A0A0A0MR97: BAZ2B; NbExp=3; IntAct=EBI-739624, EBI-11985607;
CC Q8NHQ1; Q9BXY8: BEX2; NbExp=6; IntAct=EBI-739624, EBI-745073;
CC Q8NHQ1; O95696: BRD1; NbExp=3; IntAct=EBI-739624, EBI-714754;
CC Q8NHQ1; Q9HCU9: BRMS1; NbExp=4; IntAct=EBI-739624, EBI-714781;
CC Q8NHQ1; Q5PSV4: BRMS1L; NbExp=3; IntAct=EBI-739624, EBI-5666615;
CC Q8NHQ1; P55201-2: BRPF1; NbExp=3; IntAct=EBI-739624, EBI-12065306;
CC Q8NHQ1; Q13895: BYSL; NbExp=8; IntAct=EBI-739624, EBI-358049;
CC Q8NHQ1; Q9H7E9: C8orf33; NbExp=5; IntAct=EBI-739624, EBI-715389;
CC Q8NHQ1; Q9H257: CARD9; NbExp=3; IntAct=EBI-739624, EBI-751319;
CC Q8NHQ1; Q969G5: CAVIN3; NbExp=3; IntAct=EBI-739624, EBI-3893101;
CC Q8NHQ1; Q9HC52: CBX8; NbExp=3; IntAct=EBI-739624, EBI-712912;
CC Q8NHQ1; Q16543: CDC37; NbExp=3; IntAct=EBI-739624, EBI-295634;
CC Q8NHQ1; Q6P1J9: CDC73; NbExp=10; IntAct=EBI-739624, EBI-930143;
CC Q8NHQ1; Q96GN5: CDCA7L; NbExp=7; IntAct=EBI-739624, EBI-5278764;
CC Q8NHQ1; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-739624, EBI-1104570;
CC Q8NHQ1; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-739624, EBI-10181988;
CC Q8NHQ1; Q8NHQ1: CEP70; NbExp=4; IntAct=EBI-739624, EBI-739624;
CC Q8NHQ1; Q8NHQ1-3: CEP70; NbExp=3; IntAct=EBI-739624, EBI-11526150;
CC Q8NHQ1; Q96M91: CFAP53; NbExp=3; IntAct=EBI-739624, EBI-742422;
CC Q8NHQ1; Q9H078: CLPB; NbExp=3; IntAct=EBI-739624, EBI-2107221;
CC Q8NHQ1; P38432: COIL; NbExp=3; IntAct=EBI-739624, EBI-945751;
CC Q8NHQ1; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-739624, EBI-5453285;
CC Q8NHQ1; Q9UER7: DAXX; NbExp=3; IntAct=EBI-739624, EBI-77321;
CC Q8NHQ1; Q9UJV9: DDX41; NbExp=3; IntAct=EBI-739624, EBI-1046350;
CC Q8NHQ1; P26196: DDX6; NbExp=6; IntAct=EBI-739624, EBI-351257;
CC Q8NHQ1; Q5QJE6: DNTTIP2; NbExp=3; IntAct=EBI-739624, EBI-5666736;
CC Q8NHQ1; Q92997: DVL3; NbExp=3; IntAct=EBI-739624, EBI-739789;
CC Q8NHQ1; Q96JC9: EAF1; NbExp=3; IntAct=EBI-739624, EBI-769261;
CC Q8NHQ1; Q99848: EBNA1BP2; NbExp=3; IntAct=EBI-739624, EBI-1048111;
CC Q8NHQ1; O15371: EIF3D; NbExp=3; IntAct=EBI-739624, EBI-353818;
CC Q8NHQ1; Q14241: ELOA; NbExp=3; IntAct=EBI-739624, EBI-742350;
CC Q8NHQ1; P50402: EMD; NbExp=6; IntAct=EBI-739624, EBI-489887;
CC Q8NHQ1; P54849: EMP1; NbExp=3; IntAct=EBI-739624, EBI-4319440;
CC Q8NHQ1; Q9H0I2: ENKD1; NbExp=4; IntAct=EBI-739624, EBI-744099;
CC Q8NHQ1; P19447: ERCC3; NbExp=3; IntAct=EBI-739624, EBI-1183307;
CC Q8NHQ1; Q86V42: FAM124A; NbExp=3; IntAct=EBI-739624, EBI-744506;
CC Q8NHQ1; Q8N9E0: FAM133A; NbExp=6; IntAct=EBI-739624, EBI-10268158;
CC Q8NHQ1; Q8NE31: FAM13C; NbExp=3; IntAct=EBI-739624, EBI-751248;
CC Q8NHQ1; Q3B820: FAM161A; NbExp=6; IntAct=EBI-739624, EBI-719941;
CC Q8NHQ1; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-739624, EBI-7225287;
CC Q8NHQ1; Q7L5A3: FAM214B; NbExp=5; IntAct=EBI-739624, EBI-745689;
CC Q8NHQ1; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-739624, EBI-6658203;
CC Q8NHQ1; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-739624, EBI-372506;
CC Q8NHQ1; O95995: GAS8; NbExp=3; IntAct=EBI-739624, EBI-1052570;
CC Q8NHQ1; Q8WXI9: GATAD2B; NbExp=3; IntAct=EBI-739624, EBI-923440;
CC Q8NHQ1; Q96CN9: GCC1; NbExp=6; IntAct=EBI-739624, EBI-746252;
CC Q8NHQ1; P55040: GEM; NbExp=3; IntAct=EBI-739624, EBI-744104;
CC Q8NHQ1; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-739624, EBI-748515;
CC Q8NHQ1; Q9NWQ4: GPATCH2L; NbExp=3; IntAct=EBI-739624, EBI-5666657;
CC Q8NHQ1; Q5T3I0: GPATCH4; NbExp=6; IntAct=EBI-739624, EBI-2372076;
CC Q8NHQ1; Q96SL4: GPX7; NbExp=3; IntAct=EBI-739624, EBI-749411;
CC Q8NHQ1; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-739624, EBI-2514791;
CC Q8NHQ1; Q96CS2-2: HAUS1; NbExp=3; IntAct=EBI-739624, EBI-11742270;
CC Q8NHQ1; A0A024R4Z4: hCG_2042749; NbExp=3; IntAct=EBI-739624, EBI-14231181;
CC Q8NHQ1; P56524-2: HDAC4; NbExp=3; IntAct=EBI-739624, EBI-11953488;
CC Q8NHQ1; Q96JB3: HIC2; NbExp=3; IntAct=EBI-739624, EBI-726282;
CC Q8NHQ1; Q6NSH1: HMGB4; NbExp=3; IntAct=EBI-739624, EBI-10250889;
CC Q8NHQ1; Q8WW32: HMGB4; NbExp=6; IntAct=EBI-739624, EBI-10277297;
CC Q8NHQ1; P09067: HOXB5; NbExp=3; IntAct=EBI-739624, EBI-3893317;
CC Q8NHQ1; P31273: HOXC8; NbExp=3; IntAct=EBI-739624, EBI-1752118;
CC Q8NHQ1; P10809: HSPD1; NbExp=6; IntAct=EBI-739624, EBI-352528;
CC Q8NHQ1; Q13123: IK; NbExp=3; IntAct=EBI-739624, EBI-713456;
CC Q8NHQ1; Q9C086: INO80B; NbExp=3; IntAct=EBI-739624, EBI-715611;
CC Q8NHQ1; Q15735: INPP5J; NbExp=3; IntAct=EBI-739624, EBI-10236940;
CC Q8NHQ1; Q8WWN9: IPCEF1; NbExp=3; IntAct=EBI-739624, EBI-4401965;
CC Q8NHQ1; Q8NA54: IQUB; NbExp=3; IntAct=EBI-739624, EBI-10220600;
CC Q8NHQ1; P27987: ITPKB; NbExp=3; IntAct=EBI-739624, EBI-751388;
CC Q8NHQ1; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-739624, EBI-2556193;
CC Q8NHQ1; Q7Z3B3: KANSL1; NbExp=4; IntAct=EBI-739624, EBI-740244;
CC Q8NHQ1; Q9H8E8: KAT14; NbExp=3; IntAct=EBI-739624, EBI-750907;
CC Q8NHQ1; Q92993: KAT5; NbExp=3; IntAct=EBI-739624, EBI-399080;
CC Q8NHQ1; O60341: KDM1A; NbExp=2; IntAct=EBI-739624, EBI-710124;
CC Q8NHQ1; O14901: KLF11; NbExp=3; IntAct=EBI-739624, EBI-948266;
CC Q8NHQ1; A0A494C108: KRI1; NbExp=3; IntAct=EBI-739624, EBI-12342761;
CC Q8NHQ1; Q15323: KRT31; NbExp=3; IntAct=EBI-739624, EBI-948001;
CC Q8NHQ1; A0A0C4DGV4: LAMTOR5; NbExp=6; IntAct=EBI-739624, EBI-10173304;
CC Q8NHQ1; Q96JN0-2: LCOR; NbExp=3; IntAct=EBI-739624, EBI-10961483;
CC Q8NHQ1; Q96BZ8: LENG1; NbExp=7; IntAct=EBI-739624, EBI-726510;
CC Q8NHQ1; Q96PV6: LENG8; NbExp=3; IntAct=EBI-739624, EBI-739546;
CC Q8NHQ1; Q96GY3: LIN37; NbExp=3; IntAct=EBI-739624, EBI-748884;
CC Q8NHQ1; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-739624, EBI-739832;
CC Q8NHQ1; Q9Y586: MAB21L2; NbExp=3; IntAct=EBI-739624, EBI-6659161;
CC Q8NHQ1; P61326: MAGOH; NbExp=3; IntAct=EBI-739624, EBI-299134;
CC Q8NHQ1; O95983-2: MBD3; NbExp=3; IntAct=EBI-739624, EBI-11978579;
CC Q8NHQ1; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-739624, EBI-348259;
CC Q8NHQ1; Q9H7H0: METTL17; NbExp=7; IntAct=EBI-739624, EBI-749353;
CC Q8NHQ1; Q9H7H0-2: METTL17; NbExp=3; IntAct=EBI-739624, EBI-11098807;
CC Q8NHQ1; P55081: MFAP1; NbExp=6; IntAct=EBI-739624, EBI-1048159;
CC Q8NHQ1; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-739624, EBI-14086479;
CC Q8NHQ1; Q13064: MKRN3; NbExp=3; IntAct=EBI-739624, EBI-2340269;
CC Q8NHQ1; Q9BU76: MMTAG2; NbExp=5; IntAct=EBI-739624, EBI-742459;
CC Q8NHQ1; O76041: NEBL; NbExp=3; IntAct=EBI-739624, EBI-2880203;
CC Q8NHQ1; Q9UFN0: NIPSNAP3A; NbExp=3; IntAct=EBI-739624, EBI-716291;
CC Q8NHQ1; Q6ZUT1: NKAPD1; NbExp=6; IntAct=EBI-739624, EBI-3920396;
CC Q8NHQ1; Q6ZUT1-2: NKAPD1; NbExp=3; IntAct=EBI-739624, EBI-10180231;
CC Q8NHQ1; Q9UGY1: NOL12; NbExp=4; IntAct=EBI-739624, EBI-716098;
CC Q8NHQ1; P46087: NOP2; NbExp=3; IntAct=EBI-739624, EBI-356811;
CC Q8NHQ1; Q9NZM5: NOP53; NbExp=3; IntAct=EBI-739624, EBI-720156;
CC Q8NHQ1; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-739624, EBI-12025760;
CC Q8NHQ1; P48552: NRIP1; NbExp=3; IntAct=EBI-739624, EBI-746484;
CC Q8NHQ1; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-739624, EBI-741158;
CC Q8NHQ1; Q9BXS6: NUSAP1; NbExp=3; IntAct=EBI-739624, EBI-2555618;
CC Q8NHQ1; Q96NG3: ODAD4; NbExp=3; IntAct=EBI-739624, EBI-1046387;
CC Q8NHQ1; A0A087WUI6: PIBF1; NbExp=3; IntAct=EBI-739624, EBI-11749468;
CC Q8NHQ1; Q9BSJ6: PIMREG; NbExp=6; IntAct=EBI-739624, EBI-2568609;
CC Q8NHQ1; Q16512: PKN1; NbExp=3; IntAct=EBI-739624, EBI-602382;
CC Q8NHQ1; Q13427: PPIG; NbExp=3; IntAct=EBI-739624, EBI-396072;
CC Q8NHQ1; Q96T49: PPP1R16B; NbExp=3; IntAct=EBI-739624, EBI-10293968;
CC Q8NHQ1; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-739624, EBI-2557469;
CC Q8NHQ1; Q9H875: PRKRIP1; NbExp=3; IntAct=EBI-739624, EBI-744488;
CC Q8NHQ1; Q99633: PRPF18; NbExp=3; IntAct=EBI-739624, EBI-2798416;
CC Q8NHQ1; O43395: PRPF3; NbExp=3; IntAct=EBI-739624, EBI-744322;
CC Q8NHQ1; Q8WWY3: PRPF31; NbExp=9; IntAct=EBI-739624, EBI-1567797;
CC Q8NHQ1; P25786: PSMA1; NbExp=6; IntAct=EBI-739624, EBI-359352;
CC Q8NHQ1; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-739624, EBI-11974061;
CC Q8NHQ1; A6NK89: RASSF10; NbExp=3; IntAct=EBI-739624, EBI-6912267;
CC Q8NHQ1; P98175: RBM10; NbExp=6; IntAct=EBI-739624, EBI-721525;
CC Q8NHQ1; Q8TCX5: RHPN1; NbExp=3; IntAct=EBI-739624, EBI-746325;
CC Q8NHQ1; Q8NCN4: RNF169; NbExp=3; IntAct=EBI-739624, EBI-6380946;
CC Q8NHQ1; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-739624, EBI-16428950;
CC Q8NHQ1; P26373: RPL13; NbExp=3; IntAct=EBI-739624, EBI-356849;
CC Q8NHQ1; Q6NZ55: RPL13; NbExp=3; IntAct=EBI-739624, EBI-10252046;
CC Q8NHQ1; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-739624, EBI-748391;
CC Q8NHQ1; Q92503: SEC14L1; NbExp=3; IntAct=EBI-739624, EBI-2855587;
CC Q8NHQ1; Q9C0A6-2: SETD5; NbExp=3; IntAct=EBI-739624, EBI-10303449;
CC Q8NHQ1; Q86XK3: SFR1; NbExp=3; IntAct=EBI-739624, EBI-1104535;
CC Q8NHQ1; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-739624, EBI-747035;
CC Q8NHQ1; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-739624, EBI-10308083;
CC Q8NHQ1; O95391: SLU7; NbExp=3; IntAct=EBI-739624, EBI-750559;
CC Q8NHQ1; Q969G3: SMARCE1; NbExp=6; IntAct=EBI-739624, EBI-455078;
CC Q8NHQ1; P62316: SNRPD2; NbExp=3; IntAct=EBI-739624, EBI-297993;
CC Q8NHQ1; Q13573: SNW1; NbExp=3; IntAct=EBI-739624, EBI-632715;
CC Q8NHQ1; P04179: SOD2; NbExp=3; IntAct=EBI-739624, EBI-716989;
CC Q8NHQ1; Q5MJ09: SPANXN3; NbExp=3; IntAct=EBI-739624, EBI-12037215;
CC Q8NHQ1; Q6ZRS2-3: SRCAP; NbExp=3; IntAct=EBI-739624, EBI-12029182;
CC Q8NHQ1; Q99909: SSX3; NbExp=3; IntAct=EBI-739624, EBI-10295431;
CC Q8NHQ1; O00506: STK25; NbExp=3; IntAct=EBI-739624, EBI-618295;
CC Q8NHQ1; O43463: SUV39H1; NbExp=3; IntAct=EBI-739624, EBI-349968;
CC Q8NHQ1; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-739624, EBI-745392;
CC Q8NHQ1; Q96C24: SYTL4; NbExp=4; IntAct=EBI-739624, EBI-747142;
CC Q8NHQ1; Q8TDW5: SYTL5; NbExp=4; IntAct=EBI-739624, EBI-2939487;
CC Q8NHQ1; Q8TDW5-2: SYTL5; NbExp=3; IntAct=EBI-739624, EBI-12243980;
CC Q8NHQ1; Q9H5J8: TAF1D; NbExp=4; IntAct=EBI-739624, EBI-716128;
CC Q8NHQ1; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-739624, EBI-8787464;
CC Q8NHQ1; Q9Y2I9-2: TBC1D30; NbExp=3; IntAct=EBI-739624, EBI-17455779;
CC Q8NHQ1; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-739624, EBI-11974855;
CC Q8NHQ1; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-739624, EBI-11955057;
CC Q8NHQ1; A0A0S2Z4E5: TEAD4; NbExp=3; IntAct=EBI-739624, EBI-16432288;
CC Q8NHQ1; A0A0S2Z4F2: TEAD4; NbExp=3; IntAct=EBI-739624, EBI-16429215;
CC Q8NHQ1; D3DUQ6: TEAD4; NbExp=3; IntAct=EBI-739624, EBI-10176734;
CC Q8NHQ1; Q86UE8: TLK2; NbExp=3; IntAct=EBI-739624, EBI-1047967;
CC Q8NHQ1; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-739624, EBI-765817;
CC Q8NHQ1; Q14134: TRIM29; NbExp=5; IntAct=EBI-739624, EBI-702370;
CC Q8NHQ1; O75382: TRIM3; NbExp=3; IntAct=EBI-739624, EBI-2129889;
CC Q8NHQ1; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-739624, EBI-5235829;
CC Q8NHQ1; P43897: TSFM; NbExp=4; IntAct=EBI-739624, EBI-1049298;
CC Q8NHQ1; Q3SY00: TSGA10IP; NbExp=7; IntAct=EBI-739624, EBI-10241197;
CC Q8NHQ1; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-739624, EBI-9053916;
CC Q8NHQ1; Q6ZVT0: TTLL10; NbExp=3; IntAct=EBI-739624, EBI-7844656;
CC Q8NHQ1; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-739624, EBI-11979997;
CC Q8NHQ1; Q8N3L3: TXLNB; NbExp=8; IntAct=EBI-739624, EBI-6116822;
CC Q8NHQ1; Q99757: TXN2; NbExp=3; IntAct=EBI-739624, EBI-2932492;
CC Q8NHQ1; O75604: USP2; NbExp=3; IntAct=EBI-739624, EBI-743272;
CC Q8NHQ1; Q9Y3A2: UTP11; NbExp=3; IntAct=EBI-739624, EBI-2876697;
CC Q8NHQ1; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-739624, EBI-11737646;
CC Q8NHQ1; Q68CQ4: UTP25; NbExp=8; IntAct=EBI-739624, EBI-747711;
CC Q8NHQ1; Q9NQZ2: UTP3; NbExp=3; IntAct=EBI-739624, EBI-714067;
CC Q8NHQ1; Q8TAG6: VXN; NbExp=3; IntAct=EBI-739624, EBI-12071548;
CC Q8NHQ1; Q9BW85: YJU2; NbExp=6; IntAct=EBI-739624, EBI-10300345;
CC Q8NHQ1; Q05516: ZBTB16; NbExp=4; IntAct=EBI-739624, EBI-711925;
CC Q8NHQ1; O43167: ZBTB24; NbExp=6; IntAct=EBI-739624, EBI-744471;
CC Q8NHQ1; Q9P1Z0: ZBTB4; NbExp=3; IntAct=EBI-739624, EBI-2564133;
CC Q8NHQ1; Q9UFB7: ZBTB47; NbExp=3; IntAct=EBI-739624, EBI-7781767;
CC Q8NHQ1; P10074: ZBTB48; NbExp=3; IntAct=EBI-739624, EBI-744864;
CC Q8NHQ1; Q6ZSB9: ZBTB49; NbExp=5; IntAct=EBI-739624, EBI-2859943;
CC Q8NHQ1; Q8TBK6: ZCCHC10; NbExp=4; IntAct=EBI-739624, EBI-597063;
CC Q8NHQ1; G3V1X1: ZFC3H1; NbExp=3; IntAct=EBI-739624, EBI-6448783;
CC Q8NHQ1; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-739624, EBI-10237226;
CC Q8NHQ1; Q6P2D0: ZFP1; NbExp=3; IntAct=EBI-739624, EBI-2555749;
CC Q8NHQ1; A0A0S2Z6H0: ZGPAT; NbExp=3; IntAct=EBI-739624, EBI-16428984;
CC Q8NHQ1; Q8N5A5: ZGPAT; NbExp=4; IntAct=EBI-739624, EBI-3439227;
CC Q8NHQ1; Q8N5A5-2: ZGPAT; NbExp=9; IntAct=EBI-739624, EBI-10183064;
CC Q8NHQ1; P52737: ZNF136; NbExp=5; IntAct=EBI-739624, EBI-749129;
CC Q8NHQ1; P52738: ZNF140; NbExp=3; IntAct=EBI-739624, EBI-12069140;
CC Q8NHQ1; Q9UQR1: ZNF148; NbExp=3; IntAct=EBI-739624, EBI-2688184;
CC Q8NHQ1; P49910: ZNF165; NbExp=3; IntAct=EBI-739624, EBI-741694;
CC Q8NHQ1; Q14929: ZNF169; NbExp=3; IntAct=EBI-739624, EBI-10234472;
CC Q8NHQ1; P17021: ZNF17; NbExp=3; IntAct=EBI-739624, EBI-1105334;
CC Q8NHQ1; P17024: ZNF20; NbExp=3; IntAct=EBI-739624, EBI-717634;
CC Q8NHQ1; O95125: ZNF202; NbExp=3; IntAct=EBI-739624, EBI-751960;
CC Q8NHQ1; Q86WZ6: ZNF227; NbExp=7; IntAct=EBI-739624, EBI-2799529;
CC Q8NHQ1; Q16600: ZNF239; NbExp=6; IntAct=EBI-739624, EBI-8787052;
CC Q8NHQ1; O43296: ZNF264; NbExp=4; IntAct=EBI-739624, EBI-4395808;
CC Q8NHQ1; Q14584: ZNF266; NbExp=6; IntAct=EBI-739624, EBI-7115319;
CC Q8NHQ1; Q9NR11: ZNF302; NbExp=4; IntAct=EBI-739624, EBI-3916142;
CC Q8NHQ1; Q86UD4: ZNF329; NbExp=7; IntAct=EBI-739624, EBI-7233259;
CC Q8NHQ1; P13682: ZNF35; NbExp=3; IntAct=EBI-739624, EBI-11041653;
CC Q8NHQ1; Q8N895: ZNF366; NbExp=8; IntAct=EBI-739624, EBI-2813661;
CC Q8NHQ1; Q9H9D4: ZNF408; NbExp=9; IntAct=EBI-739624, EBI-347633;
CC Q8NHQ1; Q86VK4: ZNF410; NbExp=3; IntAct=EBI-739624, EBI-720304;
CC Q8NHQ1; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-739624, EBI-740727;
CC Q8NHQ1; Q8N7K0: ZNF433; NbExp=3; IntAct=EBI-739624, EBI-10267553;
CC Q8NHQ1; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-739624, EBI-747580;
CC Q8NHQ1; Q9ULM2: ZNF490; NbExp=7; IntAct=EBI-739624, EBI-1105370;
CC Q8NHQ1; Q8N8L2: ZNF491; NbExp=3; IntAct=EBI-739624, EBI-12019860;
CC Q8NHQ1; Q8NEP9: ZNF555; NbExp=3; IntAct=EBI-739624, EBI-10270752;
CC Q8NHQ1; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-739624, EBI-10172590;
CC Q8NHQ1; Q6ZN55-2: ZNF574; NbExp=3; IntAct=EBI-739624, EBI-17189720;
CC Q8NHQ1; Q3MI94: ZNF578; NbExp=3; IntAct=EBI-739624, EBI-10241108;
CC Q8NHQ1; Q96N58: ZNF578; NbExp=3; IntAct=EBI-739624, EBI-11955189;
CC Q8NHQ1; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-739624, EBI-6427977;
CC Q8NHQ1; Q96NL3: ZNF599; NbExp=3; IntAct=EBI-739624, EBI-8653994;
CC Q8NHQ1; Q5T619: ZNF648; NbExp=3; IntAct=EBI-739624, EBI-11985915;
CC Q8NHQ1; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-739624, EBI-12006574;
CC Q8NHQ1; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-739624, EBI-16429014;
CC Q8NHQ1; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-739624, EBI-11090299;
CC Q8NHQ1; Q96BV0: ZNF775; NbExp=3; IntAct=EBI-739624, EBI-7149881;
CC Q8NHQ1; Q9ULD5: ZNF777; NbExp=3; IntAct=EBI-739624, EBI-11975599;
CC Q8NHQ1; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-739624, EBI-3925400;
CC Q8NHQ1; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-739624, EBI-5667516;
CC Q8NHQ1; A6NHJ4: ZNF860; NbExp=3; IntAct=EBI-739624, EBI-17263060;
CC Q8NHQ1; O43309: ZSCAN12; NbExp=3; IntAct=EBI-739624, EBI-1210440;
CC Q8NHQ1; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-739624, EBI-10281938;
CC Q8NHQ1; Q3MJ62: ZSCAN23; NbExp=3; IntAct=EBI-739624, EBI-5667532;
CC Q8NHQ1-3; P54253: ATXN1; NbExp=3; IntAct=EBI-11526150, EBI-930964;
CC Q8NHQ1-3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-11526150, EBI-10976677;
CC Q8NHQ1-3; Q53GS7: GLE1; NbExp=3; IntAct=EBI-11526150, EBI-1955541;
CC Q8NHQ1-3; P42858: HTT; NbExp=6; IntAct=EBI-11526150, EBI-466029;
CC Q8NHQ1-3; D3DTS7: PMP22; NbExp=3; IntAct=EBI-11526150, EBI-25882629;
CC Q8NHQ1-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-11526150, EBI-5235340;
CC Q8NHQ1-3; Q13148: TARDBP; NbExp=6; IntAct=EBI-11526150, EBI-372899;
CC Q8NHQ1-3; P54577: YARS1; NbExp=3; IntAct=EBI-11526150, EBI-1048893;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:14654843,
CC ECO:0000269|PubMed:21795687}. Note=Localized at the center of the
CC radial microtubule array in interphase and at the spindle poles during
CC various stages of mitosis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8NHQ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NHQ1-2; Sequence=VSP_012746, VSP_012747;
CC Name=3;
CC IsoId=Q8NHQ1-3; Sequence=VSP_012745;
CC Name=4;
CC IsoId=Q8NHQ1-4; Sequence=VSP_042140;
CC Name=5;
CC IsoId=Q8NHQ1-5; Sequence=VSP_042140, VSP_042141;
CC -!- DOMAIN: The coiled-coil domains may be important for tubulin-gamma-
CC binding and hence for centrosomal localization.
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DR EMBL; AF202146; AAG35616.1; -; mRNA.
DR EMBL; AF289495; AAG35791.1; -; mRNA.
DR EMBL; AK023098; BAB14403.1; -; mRNA.
DR EMBL; AK299003; BAH12924.1; -; mRNA.
DR EMBL; AK301913; BAH13584.1; -; mRNA.
DR EMBL; AC020890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC072045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79062.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79063.1; -; Genomic_DNA.
DR EMBL; BC016050; AAH16050.1; -; mRNA.
DR EMBL; BC030598; AAH30598.1; -; mRNA.
DR CCDS; CCDS3102.1; -. [Q8NHQ1-1]
DR CCDS; CCDS75022.1; -. [Q8NHQ1-4]
DR CCDS; CCDS75023.1; -. [Q8NHQ1-2]
DR CCDS; CCDS82842.1; -. [Q8NHQ1-3]
DR RefSeq; NP_001275893.1; NM_001288964.1. [Q8NHQ1-4]
DR RefSeq; NP_001275894.1; NM_001288965.1. [Q8NHQ1-5]
DR RefSeq; NP_001275895.1; NM_001288966.1. [Q8NHQ1-2]
DR RefSeq; NP_001275896.1; NM_001288967.1.
DR RefSeq; NP_001307527.1; NM_001320598.1. [Q8NHQ1-1]
DR RefSeq; NP_001307529.1; NM_001320600.1. [Q8NHQ1-3]
DR RefSeq; NP_077817.2; NM_024491.3. [Q8NHQ1-1]
DR RefSeq; XP_016862764.1; XM_017007275.1. [Q8NHQ1-1]
DR AlphaFoldDB; Q8NHQ1; -.
DR SMR; Q8NHQ1; -.
DR BioGRID; 123234; 276.
DR IntAct; Q8NHQ1; 279.
DR MINT; Q8NHQ1; -.
DR STRING; 9606.ENSP00000264982; -.
DR iPTMnet; Q8NHQ1; -.
DR PhosphoSitePlus; Q8NHQ1; -.
DR BioMuta; CEP70; -.
DR DMDM; 84028943; -.
DR EPD; Q8NHQ1; -.
DR MassIVE; Q8NHQ1; -.
DR PaxDb; Q8NHQ1; -.
DR PeptideAtlas; Q8NHQ1; -.
DR PRIDE; Q8NHQ1; -.
DR ProteomicsDB; 73734; -. [Q8NHQ1-1]
DR ProteomicsDB; 73735; -. [Q8NHQ1-2]
DR ProteomicsDB; 73736; -. [Q8NHQ1-3]
DR ProteomicsDB; 73737; -. [Q8NHQ1-4]
DR ProteomicsDB; 73738; -. [Q8NHQ1-5]
DR Antibodypedia; 46706; 222 antibodies from 26 providers.
DR DNASU; 80321; -.
DR Ensembl; ENST00000264982.8; ENSP00000264982.3; ENSG00000114107.9. [Q8NHQ1-1]
DR Ensembl; ENST00000464035.5; ENSP00000419743.1; ENSG00000114107.9. [Q8NHQ1-3]
DR Ensembl; ENST00000474781.5; ENSP00000419833.1; ENSG00000114107.9. [Q8NHQ1-4]
DR Ensembl; ENST00000481834.5; ENSP00000417465.1; ENSG00000114107.9. [Q8NHQ1-2]
DR Ensembl; ENST00000484888.5; ENSP00000419231.1; ENSG00000114107.9. [Q8NHQ1-1]
DR GeneID; 80321; -.
DR KEGG; hsa:80321; -.
DR MANE-Select; ENST00000264982.8; ENSP00000264982.3; NM_024491.4; NP_077817.2.
DR UCSC; uc003esl.5; human. [Q8NHQ1-1]
DR CTD; 80321; -.
DR DisGeNET; 80321; -.
DR GeneCards; CEP70; -.
DR HGNC; HGNC:29972; CEP70.
DR HPA; ENSG00000114107; Low tissue specificity.
DR MIM; 614310; gene.
DR neXtProt; NX_Q8NHQ1; -.
DR OpenTargets; ENSG00000114107; -.
DR PharmGKB; PA128394729; -.
DR VEuPathDB; HostDB:ENSG00000114107; -.
DR eggNOG; ENOG502QS45; Eukaryota.
DR GeneTree; ENSGT00390000009029; -.
DR HOGENOM; CLU_1351558_0_0_1; -.
DR InParanoid; Q8NHQ1; -.
DR OMA; LNGIYPR; -.
DR OrthoDB; 1217382at2759; -.
DR PhylomeDB; Q8NHQ1; -.
DR TreeFam; TF330986; -.
DR PathwayCommons; Q8NHQ1; -.
DR Reactome; R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-HSA-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-HSA-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-HSA-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-HSA-8854518; AURKA Activation by TPX2.
DR SignaLink; Q8NHQ1; -.
DR BioGRID-ORCS; 80321; 24 hits in 1044 CRISPR screens.
DR ChiTaRS; CEP70; human.
DR GeneWiki; CEP70; -.
DR GenomeRNAi; 80321; -.
DR Pharos; Q8NHQ1; Tbio.
DR PRO; PR:Q8NHQ1; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NHQ1; protein.
DR Bgee; ENSG00000114107; Expressed in calcaneal tendon and 189 other tissues.
DR ExpressionAtlas; Q8NHQ1; baseline and differential.
DR Genevisible; Q8NHQ1; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:InterPro.
DR InterPro; IPR037692; CEP70.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14594; PTHR14594; 3.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome; TPR repeat.
FT CHAIN 1..597
FT /note="Centrosomal protein of 70 kDa"
FT /id="PRO_0000089497"
FT REPEAT 483..516
FT /note="TPR"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 75..179
FT /evidence="ECO:0000255"
FT COILED 254..326
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..18
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_042140"
FT VAR_SEQ 22..23
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_042141"
FT VAR_SEQ 213..597
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_012745"
FT VAR_SEQ 551..554
FT /note="SIIY -> RYLF (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_012746"
FT VAR_SEQ 555..597
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_012747"
FT VARIANT 135
FT /note="S -> N (in dbSNP:rs1673607)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_021177"
FT VARIANT 537
FT /note="N -> S (in dbSNP:rs35340237)"
FT /id="VAR_061590"
FT CONFLICT 52
FT /note="Missing (in Ref. 2; BAB14403)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="Q -> L (in Ref. 2; BAH12924)"
FT /evidence="ECO:0000305"
FT CONFLICT 371
FT /note="Q -> R (in Ref. 2; BAB14403)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="Q -> R (in Ref. 2; BAH13584)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="V -> A (in Ref. 2; BAH13584)"
FT /evidence="ECO:0000305"
FT CONFLICT 471
FT /note="S -> P (in Ref. 1; AAG35616/AAG35791)"
FT /evidence="ECO:0000305"
FT CONFLICT 478
FT /note="D -> G (in Ref. 1; AAG35616/AAG35791)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 597 AA; 69752 MW; 345EEEB9B1F0D6C7 CRC64;
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK
QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL EQSRAANQEQ RANDLEQIME
SVKSKIGELE DESLSRACHQ QNKIKDLQKE QKTLQVKCQH YKKKRTEQEE TIASLQMEVC
RLKKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS
EEENDYRNLD ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH
NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA DQLTSLKDLY KSLKTLSAEL
VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PHFQTLQAIV SHFQKLFDVP
SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV
MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY
