ID   CEP70_MACFA             Reviewed;         597 AA.
AC   Q4R7V1;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Centrosomal protein of 70 kDa;
DE            Short=Cep70;
GN   Name=CEP70; ORFNames=QtsA-14318;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the organization of both preexisting and
CC       nascent microtubules in interphase cells. During mitosis, required for
CC       the organization and orientation of the mitotic spindle (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with tubulin-gamma; this interaction
CC       determines centrosomal localization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}.
CC   -!- DOMAIN: The coiled-coil domains may be important for tubulin-gamma-
CC       binding and hence for centrosomal localization. {ECO:0000250}.
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DR   EMBL; AB168710; BAE00821.1; -; mRNA.
DR   RefSeq; NP_001271696.1; NM_001284767.1.
DR   AlphaFoldDB; Q4R7V1; -.
DR   SMR; Q4R7V1; -.
DR   STRING; 9541.XP_005545951.1; -.
DR   GeneID; 101925551; -.
DR   CTD; 80321; -.
DR   eggNOG; ENOG502QS45; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR   GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:InterPro.
DR   InterPro; IPR037692; CEP70.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR14594; PTHR14594; 3.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; TPR repeat.
FT   CHAIN           1..597
FT                   /note="Centrosomal protein of 70 kDa"
FT                   /id="PRO_0000414855"
FT   REPEAT          483..516
FT                   /note="TPR"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          66..179
FT                   /evidence="ECO:0000255"
FT   COILED          254..320
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   597 AA;  69780 MW;  4E0445C80FB86AB1 CRC64;
     MFPVAPKPQD SNQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK
     QSSQRMRQNL KLLVEETSRQ QNMIQELIET NQQLRNELQL EHSRATNQEQ RANDLEQIME
     SVKSKIGELE DESLNRACQQ QNKIKDLQKE QRTLQVKCQH YKKKRTEQQE TIASLQTEVC
     RLRKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS
     EEENDYRSLD ASPTYKGLLM SLQNQLKESN SQIDALLSEK LNLQKDSETR PTQHELRLYK
     QQVKKLEKAL KKSVKLQELI SPKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH
     NPRAPVIIYK QSKGGAQNFN KDLIQDCGFE HLVPIIEMWA DQLTSLKDLY KSLKTLSAEL
     VPWHNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PNFQTLQAIV SHFQKLFDVP
     SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQI
     MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY