ID   CEP70_PONAB             Reviewed;         597 AA.
AC   Q5RDE3;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Centrosomal protein of 70 kDa;
DE            Short=Cep70;
GN   Name=CEP70;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the organization of both preexisting and
CC       nascent microtubules in interphase cells. During mitosis, required for
CC       the organization and orientation of the mitotic spindle (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with tubulin-gamma; this interaction
CC       determines centrosomal localization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}.
CC   -!- DOMAIN: The coiled-coil domains may be important for tubulin-gamma-
CC       binding and hence for centrosomal localization. {ECO:0000250}.
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DR   EMBL; CR857969; CAH90214.1; -; mRNA.
DR   RefSeq; NP_001125083.1; NM_001131611.1.
DR   AlphaFoldDB; Q5RDE3; -.
DR   SMR; Q5RDE3; -.
DR   STRING; 9601.ENSPPYP00000015824; -.
DR   GeneID; 100171965; -.
DR   KEGG; pon:100171965; -.
DR   CTD; 80321; -.
DR   eggNOG; ENOG502QS45; Eukaryota.
DR   InParanoid; Q5RDE3; -.
DR   OrthoDB; 1217382at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR   GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:InterPro.
DR   InterPro; IPR037692; CEP70.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR14594; PTHR14594; 3.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; TPR repeat.
FT   CHAIN           1..597
FT                   /note="Centrosomal protein of 70 kDa"
FT                   /id="PRO_0000414856"
FT   REPEAT          483..516
FT                   /note="TPR"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          66..179
FT                   /evidence="ECO:0000255"
FT   COILED          254..326
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   597 AA;  69796 MW;  E29951E1E57BDE80 CRC64;
     MFPVAPKPQD SSQASDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT DLKDLIIFDK
     QSSQRMRQNL KLLVEETSRQ QNMIQELIET NQQLRNELQL EQSRAANQEQ RANDLEQIME
     SVKSKIGELE DESLNRACQQ QNKIKDLQKE QKTLQVKCQH YKKKRTEQQE TIASLQMEVC
     RLRKEEEDRI VTQNRVFAYL CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS
     EEENDYRNLD ASPTYKGLLM SLQNQLKESK SKIDALLSEK LNLQKDLETR PTQHELRLYK
     QQVKKLEKAL KKNIKLQELI SHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ VLCSINSIIH
     NPRAPVIIYK QSKGGAQNFN KDLVQDCGFE HLVPVIEMWA DQLTSLKDLY KSLKTLSAEL
     VPWHNLKKQD ENEGIKVEDL LFIVDTMLEE VENKEKDSNM PNFQTLQAIV SHFQKLFDVP
     SLNGVYPRMN EVYTRLGEMN NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV
     MQVLGPEDLQ SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY