ID   CEP70_RAT               Reviewed;         598 AA.
AC   Q5PQQ9;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Centrosomal protein of 70 kDa;
DE            Short=Cep70;
GN   Name=Cep70;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in the organization of both preexisting and
CC       nascent microtubules in interphase cells. During mitosis, required for
CC       the organization and orientation of the mitotic spindle (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with tubulin-gamma; this interaction
CC       determines centrosomal localization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}.
CC   -!- DOMAIN: The coiled-coil domains may be important for tubulin-gamma-
CC       binding and hence for centrosomal localization. {ECO:0000250}.
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DR   EMBL; BC087075; AAH87075.1; -; mRNA.
DR   RefSeq; NP_001017470.1; NM_001017470.1.
DR   RefSeq; XP_006243701.1; XM_006243639.1.
DR   AlphaFoldDB; Q5PQQ9; -.
DR   SMR; Q5PQQ9; -.
DR   STRING; 10116.ENSRNOP00000053430; -.
DR   PaxDb; Q5PQQ9; -.
DR   PRIDE; Q5PQQ9; -.
DR   Ensembl; ENSRNOT00000056590; ENSRNOP00000053430; ENSRNOG00000022845.
DR   GeneID; 367153; -.
DR   KEGG; rno:367153; -.
DR   UCSC; RGD:1561486; rat.
DR   CTD; 80321; -.
DR   RGD; 1561486; Cep70.
DR   eggNOG; ENOG502QS45; Eukaryota.
DR   GeneTree; ENSGT00390000009029; -.
DR   HOGENOM; CLU_032136_0_0_1; -.
DR   InParanoid; Q5PQQ9; -.
DR   OrthoDB; 1217382at2759; -.
DR   PhylomeDB; Q5PQQ9; -.
DR   TreeFam; TF330986; -.
DR   Reactome; R-RNO-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-RNO-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-RNO-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-RNO-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-RNO-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-RNO-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-RNO-8854518; AURKA Activation by TPX2.
DR   PRO; PR:Q5PQQ9; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000022845; Expressed in testis and 19 other tissues.
DR   ExpressionAtlas; Q5PQQ9; baseline and differential.
DR   Genevisible; Q5PQQ9; RN.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR   GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:InterPro.
DR   InterPro; IPR037692; CEP70.
DR   PANTHER; PTHR14594; PTHR14594; 3.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; TPR repeat.
FT   CHAIN           1..598
FT                   /note="Centrosomal protein of 70 kDa"
FT                   /id="PRO_0000414857"
FT   REPEAT          484..517
FT                   /note="TPR"
FT   REGION          16..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          99..210
FT                   /evidence="ECO:0000255"
FT   COILED          255..317
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        16..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   598 AA;  68893 MW;  3EDEB90C72759A80 CRC64;
     MTEGTQVFLL PISTSDSTKE PLSTVTSQAQ DSSLSANRPV TEKQQEEAEW ESISRLLVTR
     GFKPLCLVKG ANLRDFIVFD KQSSQRMRQA FKTLMEETTR QQSMLQELIE TNHQLKSELQ
     LEQNRAAHQE QRANDLQQIM DSVKSKIGEL EDESLNRVCQ EQNRIKDLQK EYKTLQMKCQ
     HYKKKQMEQE ETIASLQKEI RRFAKEEEDR VITQKRLFTH LCRRVPHSVL DKQQCGEDDS
     QSEGKDYLNL GVSPTYKGLL TSLQKQLEKS NSKIDVLLGE KLNLQKDLEN RPTEHELRLY
     KQQVKKLEKT LKKNIKLQDL IGQKKSDDME KKDEPSKDIH QQALVDQRYF QVLCSIDSIV
     HSPRAPGVIY KQSKERAQNR SKDAVQECGF EHLVPVIEMW ADELTSLKDL YKSLKILSAE
     LIPWHNLKKP NENEGVKVGD LLLMVDTMLE EVENQKETSS MPNSQTLQAI VSHFQKLFDV
     QSLNGVYPRM NEVYARLGEM NNAVRNLQEL LGLDSSSSLC MVVSTVGKLC KMINEDVSEQ
     IKRVLGPEDL QSIINKLEEH EEFFPAFQAF TNDLLEILEI DDLDAIVPAV KKLKVLSY