CEP72_DANRE
ID CEP72_DANRE Reviewed; 532 AA.
AC Q501X2;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Centrosomal protein of 72 kDa;
DE Short=Cep72;
GN Name=cep72;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the recruitment of key centrosomal proteins to
CC the centrosome. Provides centrosomal microtubule-nucleation activity on
CC the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles
CC in forming a focused bipolar spindle, which is needed for proper
CC tension generation between sister chromatids. Involved in centriole
CC duplication (By similarity). {ECO:0000250|UniProtKB:Q9P209}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q9P209}.
CC -!- SIMILARITY: Belongs to the CEP72 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH95832.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC095832; AAH95832.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q501X2; -.
DR SMR; Q501X2; -.
DR STRING; 7955.ENSDARP00000075142; -.
DR PaxDb; Q501X2; -.
DR PRIDE; Q501X2; -.
DR ZFIN; ZDB-GENE-101115-1; cep72.
DR eggNOG; ENOG502QV2Y; Eukaryota.
DR InParanoid; Q501X2; -.
DR PhylomeDB; Q501X2; -.
DR Reactome; R-DRE-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-DRE-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-DRE-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-DRE-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-DRE-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-DRE-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-DRE-8854518; AURKA Activation by TPX2.
DR PRO; PR:Q501X2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0033566; P:gamma-tubulin complex localization; ISS:UniProtKB.
DR GO; GO:0007051; P:spindle organization; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 3.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Leucine-rich repeat;
KW Reference proteome; Repeat.
FT CHAIN 1..532
FT /note="Centrosomal protein of 72 kDa"
FT /id="PRO_0000381811"
FT REPEAT 52..73
FT /note="LRR 1"
FT REPEAT 74..95
FT /note="LRR 2"
FT DOMAIN 108..147
FT /note="LRRCT"
FT REGION 247..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 385..532
FT /evidence="ECO:0000255"
SQ SEQUENCE 532 AA; 61297 MW; 7EB8D70F045714B3 CRC64;
MAVDGLPITE QWIREKLNLQ HRCLADVRSL TLPGTYEGKI CHLGTSLKNF VRLKSLDLSY
NALVTVQGIE HLELLERLNL YYNRLASLQD IFSLHKLQNL KELDLRLNPV VKKHPHYRLY
LVHAIPKLRR LDDCPVRDRE RKAALMHFSS EENLDSDYKK QVFIQDTTAR SSDLRIKAMQ
KMVKTLSLLE GNEELALNDS SRKTGKRRSL QTLSVRCENE CSPLLAHENP SESDIVYLFN
DSDCRRSSKH KQESAPSKSS DYKNDARAGP HRVRFVSPVI LRHSSVRGES VFTAHPDSHK
QPHSHENDCS SPKWQNQLLD RANLVLHPPR LTYSTAETKD RSTKTLKGTY RKPMELLLSM
MEDLWSEKKE NQQNRTFLMK MVQILSMMEQ EVSGGEQEIQ TLKAALKASI AQADVQEKQH
QSEIEELTLQ QQQAHESIKR LNEQTKSLLE ENVSLQKQLI RAEHKLLASR LKNIPHTQDR
GVQSVPEEFN TKRDIIADDE DGGVGEQQQS YRSLIARNER LLQQLEEALM SK