ID   CEP76_DANRE             Reviewed;         662 AA.
AC   A7E2V1;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Centrosomal protein of 76 kDa;
DE            Short=Cep76;
GN   Name=cep76; ORFNames=zgc:162328;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC       duplication. Required to limit centriole duplication to once per cell
CC       cycle by preventing centriole reduplication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole {ECO:0000250}. Note=Does not
CC       localize along the ciliary axoneme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CEP76 family. {ECO:0000305}.
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DR   EMBL; BC151203; AAI51204.1; -; mRNA.
DR   AlphaFoldDB; A7E2V1; -.
DR   STRING; 7955.ENSDARP00000075595; -.
DR   PaxDb; A7E2V1; -.
DR   ZFIN; ZDB-GENE-070820-5; cep76.
DR   eggNOG; ENOG502QQEI; Eukaryota.
DR   InParanoid; A7E2V1; -.
DR   PhylomeDB; A7E2V1; -.
DR   Reactome; R-DRE-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-DRE-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-DRE-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-DRE-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-DRE-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-DRE-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-DRE-8854518; AURKA Activation by TPX2.
DR   PRO; PR:A7E2V1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR   InterPro; IPR028926; CEP76-C2.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF15627; CEP76-C2; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..662
FT                   /note="Centrosomal protein of 76 kDa"
FT                   /id="PRO_0000378950"
SQ   SEQUENCE   662 AA;  74378 MW;  5EC34C69A6A33504 CRC64;
     MSLSPEKANE LKQIIHDHLI KMDIHGKIRD VLTETVQGDG HHKQCLLSEE DFMHALQRRG
     IVNDVMKDLH FTNMYNSHTE ADSVNKSATH FMDQNITQLK TANIGQLKRQ LYLQVVGGKA
     FLEQLQEPEP LPGQVCSTFT LHVHFRNQRF RSKPIPCACE PDIQEGFLLE IHRDGPGDAS
     KMADATTMLS ICDPVHMVLI KTDTSGDTTL VSSYFLDWRT VLSAPNGKIS VSAELLGVGA
     EAKVPAGVLN LKLELYPPLT ETLSPDVVTM QKSLERQKTA EKERLFLVYA KQWWQEFLDI
     RPSNKSKLVK IFAQDENGVN RPVCSYVRVL RAGRLLESPR QAARFVSLLA QERAPVVGGG
     VRQEQWASMM VFLCRNKGDC EDHATLLCSL LLGFGLDAYV CVGTKVKNIP HTWVMTCGTD
     GSITFWESFT AHRYLHRPID PDAPSMILQP KPVHPYQTLG CVFNHKIFLA NCQVSDAVER
     CVFDFTDGSR WKAMSEEAVR SVCDPGFNTS LPPTPPLCSS SLVPNEASNQ LELEMRYLLS
     EHRKDLGLAT VWDDHLSYLL SAALSAYELE RCAGVSYGNE EFQDAVRRAV PDGHTFKAFP
     INFLHCNARR AFATCLRSPF CEEIVCCRGD HVRLAVRVRV FGYPESACAV WIMFACKYRS
     VL