CEP76_MOUSE
ID CEP76_MOUSE Reviewed; 659 AA.
AC Q0VEJ0;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Centrosomal protein of 76 kDa;
DE Short=Cep76;
GN Name=Cep76;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND SER-83, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC duplication. Required to limit centriole duplication to once per cell
CC cycle by preventing centriole reduplication (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CCP110 and CEP97. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole {ECO:0000250}. Note=Does not
CC localize along the ciliary axoneme. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CEP76 family. {ECO:0000305}.
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DR EMBL; CH466528; EDL09636.1; -; Genomic_DNA.
DR EMBL; BC119216; AAI19217.1; -; mRNA.
DR EMBL; BC119218; AAI19219.1; -; mRNA.
DR CCDS; CCDS37850.1; -.
DR RefSeq; NP_001074542.1; NM_001081073.1.
DR AlphaFoldDB; Q0VEJ0; -.
DR SMR; Q0VEJ0; -.
DR BioGRID; 230419; 48.
DR IntAct; Q0VEJ0; 19.
DR STRING; 10090.ENSMUSP00000095149; -.
DR iPTMnet; Q0VEJ0; -.
DR PhosphoSitePlus; Q0VEJ0; -.
DR EPD; Q0VEJ0; -.
DR jPOST; Q0VEJ0; -.
DR MaxQB; Q0VEJ0; -.
DR PaxDb; Q0VEJ0; -.
DR PeptideAtlas; Q0VEJ0; -.
DR PRIDE; Q0VEJ0; -.
DR ProteomicsDB; 280071; -.
DR Antibodypedia; 21948; 158 antibodies from 23 providers.
DR Ensembl; ENSMUST00000097542; ENSMUSP00000095149; ENSMUSG00000073542.
DR GeneID; 225659; -.
DR KEGG; mmu:225659; -.
DR UCSC; uc008fmq.1; mouse.
DR CTD; 79959; -.
DR MGI; MGI:1923401; Cep76.
DR VEuPathDB; HostDB:ENSMUSG00000073542; -.
DR eggNOG; ENOG502QQEI; Eukaryota.
DR GeneTree; ENSGT00390000000781; -.
DR HOGENOM; CLU_027144_0_0_1; -.
DR InParanoid; Q0VEJ0; -.
DR OMA; SFFANCQ; -.
DR OrthoDB; 663144at2759; -.
DR PhylomeDB; Q0VEJ0; -.
DR TreeFam; TF329324; -.
DR Reactome; R-MMU-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-MMU-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-MMU-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-MMU-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-MMU-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-MMU-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-MMU-8854518; AURKA Activation by TPX2.
DR BioGRID-ORCS; 225659; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Cep76; mouse.
DR PRO; PR:Q0VEJ0; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q0VEJ0; protein.
DR Bgee; ENSMUSG00000073542; Expressed in spermatocyte and 212 other tissues.
DR Genevisible; Q0VEJ0; MM.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR InterPro; IPR028926; CEP76-C2.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR Pfam; PF15627; CEP76-C2; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..659
FT /note="Centrosomal protein of 76 kDa"
FT /id="PRO_0000378949"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 83
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 659 AA; 74303 MW; 658CF10C0C3A74B5 CRC64;
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE DLIKALRRRG
IIDDVMKELN FVTDSVDQEL PSSPKQTVGF DKQSTLKKTN VDPTRRYLYL QVLGGKAFLE
HLQEPEPLPG QICSTFTLCL HYRNQRFRSK PVPCACEPDF HDGFLLEVHR ESLGDGTRMA
DSTTMLSISD PIHMVLIKTD IFGETTLVAS YFLEWRSVLG SENGVTNLTV ELMGVGTESK
VSVGILNIKL EMYPPLSQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER APVIGGGGKQ
EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG TKAKGAPHAW VMTCGTDGTI
MFWESLTGHR YIHKPTNPDG PPLAEQPKPL YPYRTIGCVF NHQMFLGNCQ PSDAVETCIF
DLNDESKWKP MSEEAIKSVC APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR
KDLGLTTVWE DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM FACKYRSVL
