CEP76_PONAB
ID CEP76_PONAB Reviewed; 658 AA.
AC Q5RCP7;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=Centrosomal protein of 76 kDa;
DE Short=Cep76;
GN Name=CEP76;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC duplication. Required to limit centriole duplication to once per cell
CC cycle by preventing centriole reduplication (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CCP110 and CEP97. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole {ECO:0000250}. Note=Does not
CC localize along the ciliary axoneme. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CEP76 family. {ECO:0000305}.
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DR EMBL; CR858222; CAH90460.1; -; mRNA.
DR RefSeq; NP_001125237.1; NM_001131765.1.
DR AlphaFoldDB; Q5RCP7; -.
DR STRING; 9601.ENSPPYP00000010081; -.
DR GeneID; 100172131; -.
DR KEGG; pon:100172131; -.
DR CTD; 79959; -.
DR eggNOG; ENOG502QQEI; Eukaryota.
DR InParanoid; Q5RCP7; -.
DR OrthoDB; 663144at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR InterPro; IPR028926; CEP76-C2.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR Pfam; PF15627; CEP76-C2; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..658
FT /note="Centrosomal protein of 76 kDa"
FT /id="PRO_0000089502"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0VEJ0"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TAP6"
SQ SEQUENCE 658 AA; 74317 MW; D746E197B346B95F CRC64;
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQHLSTED LIKALRRRGI
IDDVMKELNF VTDSVERELP SSPKQPICFD RQSTLKKTNI DPTRRYLYLQ VLGGKAFLEH
LQEPEPLPGQ VCSTFTLCLH YRNQRFRSKP VPCACEPDFH DGFLLEVHRE SLGDGTRMAD
STTMLSISDP IHMVLIKTDI FGETTLVASY FLEWRSVLGS ENGVTSLTVE LMGVGTESKV
SVGILNIKLE MYPPLNQTLS QEVVNTQLAL ERQKTAEKER LFLVYAKQWW REYLQIRPSH
NSRLVKIFAQ DENGVNRPVC SYVKPLRAGR LLDTPRQAAR FVNVLGYERA PVIGGGGKQE
QWCTLLAFLC RNKGDCEDHA NLLCSLLLGY GLEAFVCVGT KAKGVPHAWV MTCGTDGTTT
FWESLTGHRY IHKPTNPDEP PVAEQPKPLY PYRTIGCVFN HQMFLGNCQP SDAVETCVFD
LNDESKWKPM SEEAIKSVCA PGATTSLPPF PPLCASTIDA SVTSNEIEMQ LRLLVSEHRK
DLGLTTVWED QLSYLLSPAL ASYEFERTTS ISAGNEEFQD AIRRAVPDGH TFKGFPIHFV
YRNARRAFAT CLRSPFCEEI ICCRGDQVRL AVRVRVFTYP ESACAVWIMF ACKYRSVL