ID   CEP76_XENLA             Reviewed;         661 AA.
AC   Q6DDX8;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Centrosomal protein of 76 kDa;
DE            Short=Cep76;
GN   Name=cep76;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC       duplication. Required to limit centriole duplication to once per cell
CC       cycle by preventing centriole reduplication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole {ECO:0000250}. Note=Does not
CC       localize along the ciliary axoneme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CEP76 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC077373; AAH77373.1; -; mRNA.
DR   RefSeq; XP_018123352.1; XM_018267863.1.
DR   AlphaFoldDB; Q6DDX8; -.
DR   GeneID; 108719185; -.
DR   KEGG; xla:108719185; -.
DR   OMA; SFFANCQ; -.
DR   OrthoDB; 663144at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 108719185; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR   InterPro; IPR028926; CEP76-C2.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF15627; CEP76-C2; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..661
FT                   /note="Centrosomal protein of 76 kDa"
FT                   /id="PRO_0000378951"
SQ   SEQUENCE   661 AA;  74966 MW;  0FFF4EE00EBF78B8 CRC64;
     MALPPEKATE LKQIIHEQLT RMDVHGKIRE VLAESLREEF QTESQQLSEE DLMQALRQRG
     IVDEVMKELH FMEDRHTREL TSTPKPATHY IDKETRSLRK TNVDPTRRYL HLQVLNGKAF
     LEHLQESDPL PGQACSTFTL CLHFRNQRFR SKPVPCACEP DFQDGFLLEV HKDSLGDGSK
     MADATTMLSI CDPVQLVLLK TDTSGETTLV SSHFLEWRSI LGTEKGVTSL AVELLGVGSE
     CKVSVGVLNV KLELYPPLNK TLSQEVINTQ LTLERQKTAE KERLFLVYAK QWWREYLQIR
     PSHNSRLVKI FAQDENWVNR PVCSYIRPLR AGRLLDTPRQ AARFVNVLGY ERAPTVGGGG
     KPEQWCTLLA FLCRNKGDCE DHCNLLCCLL LGFGLDAYVC VGTKGRGQAH TWVMTCGADG
     AITFWESLTG HRYVHKPINP DDPPMVEQPK PLYPYKTIGC VFSHKRFLAN SQPLDAVEVC
     VFDLHDESRW KPMSEEAIKS VCSPGSLASL PPFPPLCSSL LDAATESNEI ELQLRLLVLE
     HRKDLDLTTV WDDQLSYLLS PALASYEIER TTGISAGNEE FQDSIRRAVP DGHTFKGFPI
     HFVHRNARRA FATCLRSPFC DEIISCRGDQ MRLAVRVRVY TYPEAACAVW IMFACKYRCV
     L