ID   CEP76_XENTR             Reviewed;         661 AA.
AC   Q28DH9; B0JYZ5;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Centrosomal protein of 76 kDa;
DE            Short=Cep76;
GN   Name=cep76; ORFNames=TEgg032c01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC       duplication. Required to limit centriole duplication to once per cell
CC       cycle by preventing centriole reduplication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole {ECO:0000250}. Note=Does not
CC       localize along the ciliary axoneme. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q28DH9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q28DH9-2; Sequence=VSP_037628, VSP_037629;
CC   -!- SIMILARITY: Belongs to the CEP76 family. {ECO:0000305}.
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DR   EMBL; CR855505; CAJ81499.1; -; mRNA.
DR   EMBL; BC158976; AAI58977.1; -; mRNA.
DR   RefSeq; NP_001016831.1; NM_001016831.2. [Q28DH9-1]
DR   AlphaFoldDB; Q28DH9; -.
DR   STRING; 8364.ENSXETP00000042582; -.
DR   PaxDb; Q28DH9; -.
DR   Ensembl; ENSXETT00000042582; ENSXETP00000042582; ENSXETG00000019671.
DR   GeneID; 549585; -.
DR   KEGG; xtr:549585; -.
DR   CTD; 79959; -.
DR   Xenbase; XB-GENE-966809; cep76.
DR   eggNOG; ENOG502QQEI; Eukaryota.
DR   HOGENOM; CLU_027144_0_0_1; -.
DR   InParanoid; Q28DH9; -.
DR   OMA; TCIIVDL; -.
DR   OrthoDB; 663144at2759; -.
DR   PhylomeDB; Q28DH9; -.
DR   TreeFam; TF329324; -.
DR   Reactome; R-XTR-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-XTR-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-XTR-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-XTR-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-XTR-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-XTR-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-XTR-8854518; AURKA Activation by TPX2.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000019671; Expressed in 2-cell stage embryo and 12 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR   InterPro; IPR028926; CEP76-C2.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF15627; CEP76-C2; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..661
FT                   /note="Centrosomal protein of 76 kDa"
FT                   /id="PRO_0000378952"
FT   VAR_SEQ         314..320
FT                   /note="DENWVNR -> VYSELLI (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_037628"
FT   VAR_SEQ         321..661
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_037629"
SQ   SEQUENCE   661 AA;  74928 MW;  32D7E7C96E876FF6 CRC64;
     MALPPEKATE LKQIIHEQLT RMDVHGKIRE VLAESLREEF RTESQQLSEE DLMKALRQRG
     IVDEVMKELH FMEDRNTREL TSTPKPATHF IDKEPRTLKK TNVDPTRRYL HLQVLSGKAF
     LEHLQESDPL PGQACSTFTL CLHFRNQRFR SKPVPCACEP DFQDGFLLEV HKDSLGDGSR
     MADATTMLSI CDPVQLVLLK TDTSGETSLV SSHFLEWRSV LGTEKGATSL VVELLGVGAE
     CKVSVGILNV KLELYPLLNK TLSQEVINTQ FTLERQKTAE KERLFLVYAK QWWREYLQIR
     PSHNSRLVKI FAQDENWVNR PVCSYIRPLR AGRLLDTPRQ AARFVNVLGY ERAPTVGGGG
     KQEQWCTLLA FLCRNKGDCE DHCNLLCSLL LGFGLDAYVC VGTKGRGQAH TWVMTCGTDG
     AITFWESLTG HRYVHKPINP DDPPMVEQPK PLYPYKTIGC VFNHKRFLAN SQPLDAVEVC
     VFDLHDESRW KPMSEEAIKS VCSPGSIASL PPFPPLCGSL LDAATESNEI ELQLRVLVLE
     HRKDLGLTTV WDDQLSYLLS PALASYEIER TTGISAGNEE FQDCIRRAVP DGHTFKGFPI
     HFVHRNARRA FATCLRSPFC DEIISCRGDQ MRLAVRVRVY TYPEAACAVW IMFACKYRSV
     L