CEP78_DROME
ID CEP78_DROME Reviewed; 818 AA.
AC Q9VFH6; Q8MZ87;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein Cep78 homolog;
GN ORFNames=CG7886;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: May play a role in cilium biogenesis.
CC {ECO:0000250|UniProtKB:Q5JTW2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q5JTW2}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q5JTW2}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250|UniProtKB:Q5JTW2}.
CC -!- SIMILARITY: Belongs to the CEP78 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014297; AAF55081.2; -; Genomic_DNA.
DR EMBL; AY113304; AAM29309.1; -; mRNA.
DR RefSeq; NP_650378.1; NM_142121.2.
DR AlphaFoldDB; Q9VFH6; -.
DR BioGRID; 66849; 3.
DR IntAct; Q9VFH6; 3.
DR STRING; 7227.FBpp0082435; -.
DR PaxDb; Q9VFH6; -.
DR DNASU; 41775; -.
DR EnsemblMetazoa; FBtr0082976; FBpp0082435; FBgn0038248.
DR GeneID; 41775; -.
DR KEGG; dme:Dmel_CG7886; -.
DR UCSC; CG7886-RA; d. melanogaster.
DR FlyBase; FBgn0038248; CG7886.
DR VEuPathDB; VectorBase:FBgn0038248; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00390000013287; -.
DR HOGENOM; CLU_011224_1_0_1; -.
DR InParanoid; Q9VFH6; -.
DR OMA; GDMHMES; -.
DR OrthoDB; 310927at2759; -.
DR PhylomeDB; Q9VFH6; -.
DR BioGRID-ORCS; 41775; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41775; -.
DR PRO; PR:Q9VFH6; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038248; Expressed in testis and 9 other tissues.
DR ExpressionAtlas; Q9VFH6; baseline and differential.
DR Genevisible; Q9VFH6; DM.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; ISS:FlyBase.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR026212; Cep78.
DR InterPro; IPR032675; LRR_dom_sf.
DR PRINTS; PR02062; CENTROSOME78.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Reference proteome.
FT CHAIN 1..818
FT /note="Protein Cep78 homolog"
FT /id="PRO_0000291955"
FT REGION 513..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..536
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 183
FT /note="S -> T (in Ref. 3; AAM29309)"
FT /evidence="ECO:0000305"
FT CONFLICT 489
FT /note="P -> L (in Ref. 3; AAM29309)"
FT /evidence="ECO:0000305"
FT CONFLICT 610
FT /note="V -> L (in Ref. 3; AAM29309)"
FT /evidence="ECO:0000305"
FT CONFLICT 626
FT /note="A -> G (in Ref. 3; AAM29309)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 818 AA; 92782 MW; 1C0472C13A45E3D8 CRC64;
MSVSRVTMMR KGHSGEVARK PNTVVVSVPP LVKKSSKSRS FHFRYLELCR AKNLTPVPEI
RSKSNATTTF LELCGDKLAV SDWQLLTEAL HYDLVLQQLV VRLRRTYPQT NIDPIDTEKR
ARLFRQRPVI YTRFIFNSLV QAIANCVSSN KNLSVLKLEG LPLQDGYIET IAKALADNEC
LESVSFRKSN IGDKGCEVVC NTAKYLNRIE VFDLSECGLT SKGAEHVADM LKMQKITRFT
EGWEKSLRYR SVDVNTIGGL RTVLLADNPE IGDVGIRWIT EVLKEDAWIK KIDMEGCGLT
DIGANLILDC LELNTAITEF NVRNNEGISK FLQRSIHDRL GCLPEEKQEP EYDLSCVNGL
QSLPKNKKVT VSQLLSHTKA LEEQLSFERT LRKKAEKLNE KLSHQLMRPD SNHMVQEKAM
EGGSQTNISR EYVARNDVMP EVIKNSQSYR QSHFNRLVNS AATSPEVTPR SEIVTLRKEQ
QLQRQQPPPM EVKHLSLEQQ IRNLRDVQKK VDLDVEEEEE EEEEEQQAEE SQSESEPQNE
EQQHYEQQMQ VQRKHLQVRK VRSEIKYVEN NPKEAAKKNR ESKSDHEFAN ERDFKLNPSV
QFETDIGDNV MVNPGHRYEG GGGDTAYVYN YEHEQQQQPV KRGYEHGYVV GVGDGSHRRQ
RQSQLVEALV QKRVPGASDG HVAQFVSNLE RQANAGKTGK KRLKPRPEDD LQVPVGDMHM
ESSYMSRSEE LSSTDVTLEN SDYETEATDS TLLSSSKYSS MHVFVRRKQS ESMSLTEEAG
DGDAGGGGGS GDFGDQNVIS PANVYMSLQL QKQREQSA
