ID   CEP78_XENTR             Reviewed;         727 AA.
AC   A2RRS8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Centrosomal protein of 78 kDa;
DE            Short=Cep78;
GN   Name=cep78;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be required for efficient PLK4 centrosomal localization
CC       and PLK4-induced overduplication of centrioles. May play a role in
CC       cilium biogenesis. {ECO:0000250|UniProtKB:Q5JTW2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q5JTW2}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q5JTW2}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250|UniProtKB:Q5JTW2}.
CC   -!- SIMILARITY: Belongs to the CEP78 family. {ECO:0000305}.
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DR   EMBL; BC131834; AAI31835.1; -; mRNA.
DR   RefSeq; NP_001090753.1; NM_001097284.1.
DR   AlphaFoldDB; A2RRS8; -.
DR   SMR; A2RRS8; -.
DR   PaxDb; A2RRS8; -.
DR   GeneID; 100037836; -.
DR   KEGG; xtr:100037836; -.
DR   CTD; 84131; -.
DR   Xenbase; XB-GENE-5884411; cep78.
DR   eggNOG; KOG4308; Eukaryota.
DR   InParanoid; A2RRS8; -.
DR   OrthoDB; 982225at2759; -.
DR   Reactome; R-XTR-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-XTR-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-XTR-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-XTR-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-XTR-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-XTR-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-XTR-8854518; AURKA Activation by TPX2.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR026212; Cep78.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 2.
DR   PRINTS; PR02062; CENTROSOME78.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..727
FT                   /note="Centrosomal protein of 78 kDa"
FT                   /id="PRO_0000291954"
FT   REGION          567..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..599
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        647..664
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        703..727
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  80582 MW;  C43A1AFB770DF049 CRC64;
     MIDSVRIRHQ GSMDFLSHYE YLCALQDSVP IPAVKANIRH GSLSFNADRI KLSDWLPILN
     SLKINKSLLN VSIKSCHQPG LGEFGAEKYG IYFKRRIPPI RSKDMTFQVC KAITSCLSVS
     GSLKELELHG LPLRERDLRI LAKGLAASSS VESLSLAYCS CGDEGLEIIC QSVKNSPTIK
     TVNFTGCNLT WRGAEHIASI IKHQATRRHS EAWAESLRYR RPDLDCMAGL RRVTLNSNTL
     VGDRGAIALA EVIGEDLWLK ALDLRQCGIS NEGAQAFLNA FQTNTTLIIL DIRRNPLIDR
     SLLKTIIERV LMNAHDTNSE YKWYTSPSSK DNGKVRQKWR SINNWNGRKG KNIVRVGFST
     KKPMVIGRKY SSKELYCPDP RPPGAEGFLP WRTAERAKRH RDVSGEWASP GKADTAVKVI
     MDSETSSESE KSDNILSILD QEYAVPGSGE KKSVKNYKCL QLEFENTRLR QINHTLSESL
     HSRTATSVIL EDEGVLDSIE KSFSKFHAFL DLLKDAGLGQ LANLAGIDQS DFALPGDPQM
     SSTIDKIAQQ APMPHQDQQE TFFIHQAQSR DKKGEHTGPS ESNALTADTL PSSREADKYC
     TTSQKSKEGF DPDLKAREAN VNSGRLPALE NAQTYLYDKK GSRNECSASD SSRSQRSSLG
     QKSKASASEK ERKPSSKRSH SSGTNKASQE SIAARDEKAA ARSNASISES EIQEKMNSSE
     SMHSGSH