ID   CEP83_DANRE             Reviewed;         716 AA.
AC   F1R4Y7; H0WF82;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 2.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Centrosomal protein of 83 kDa;
DE            Short=Cep83;
DE   AltName: Full=Coiled-coil domain-containing protein 41;
GN   Name=cep83; Synonyms=ccdc41;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=23530209; DOI=10.1073/pnas.1220927110;
RA   Joo K., Kim C.G., Lee M.S., Moon H.Y., Lee S.H., Kim M.J., Kweon H.S.,
RA   Park W.Y., Kim C.H., Gleeson J.G., Kim J.;
RT   "CCDC41 is required for ciliary vesicle docking to the mother centriole.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:5987-5992(2013).
CC   -!- FUNCTION: Component of the distal appendage region of the centriole
CC       involved in the initiation of primary cilium assembly.
CC       {ECO:0000269|PubMed:23530209}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}. Note=Localizes
CC       specifically to the distal appendage region of the centriole, which
CC       anchors the mother centriole to the plasma membrane. Localizes to
CC       centrioles at all stages of the cell cycle, including mitosis (By
CC       similarity). {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Reduction of olfactory cilia formation.
CC       {ECO:0000269|PubMed:23530209}.
CC   -!- SIMILARITY: Belongs to the CEP83 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CABZ01023256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU693442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F1R4Y7; -.
DR   SMR; F1R4Y7; -.
DR   STRING; 7955.ENSDARP00000072564; -.
DR   PaxDb; F1R4Y7; -.
DR   ZFIN; ZDB-GENE-110321-1; cep83.
DR   eggNOG; ENOG502QWE2; Eukaryota.
DR   InParanoid; F1R4Y7; -.
DR   TreeFam; TF329199; -.
DR   Reactome; R-DRE-5620912; Anchoring of the basal body to the plasma membrane.
DR   PRO; PR:F1R4Y7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0097539; C:ciliary transition fiber; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR   GO; GO:0051660; P:establishment of centrosome localization; IBA:GO_Central.
DR   GO; GO:0048278; P:vesicle docking; IEA:InterPro.
DR   InterPro; IPR029631; Cep83.
DR   PANTHER; PTHR23170:SF2; PTHR23170:SF2; 1.
PE   3: Inferred from homology;
KW   Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..716
FT                   /note="Centrosomal protein of 83 kDa"
FT                   /id="PRO_0000422823"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          691..716
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          55..638
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        695..709
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   716 AA;  83912 MW;  B5E60279640185FE CRC64;
     MDKMNPPALG QASALFPDLE PPGGVGKATV LLGGSTGLTS SDMEFQKMLI DERMRCENHK
     TNYQTLKVEH TRLQDQYTRA QNELKRLLSD RQVTQEKQQL LLAELRGELL DKTRDLEELK
     LQVLTPQRLE LLRAQVQQEL EAPIRERFNK LQEEAENYRS EYNKLRYDLT FLKSEFDHQK
     EEHARVLEER RIRHEADVAR LEHDKEDLAT QLQSGDPARD GKRVEALLRE KAQLHQRLRG
     LEAEVTELRA ERNNSGAQAE NVQRIQIRQL AESQAAVKAL EAEKQSIRMQ LDRTESELRL
     SQEQNTLLTG KLHKAEREIN SLNSQVEEMK HTHKLELSNV KLECVRSKGE LERERDMLQC
     QVEGLQSDIE VMKSALERNK ELISEKEREM VRRVQAAREE EIHKMATLQE EKLELENRLS
     ELEQQKALQE VTGNSQKEEW EERLRAAQLG EESVRKELQN LRTKVQQQGQ QLEELETLKA
     ENADLRQQIA ELNLQVGTLS HSESELLDTN NRLRESLERV REDLRSARTQ MERTQQEAER
     LVEERRVEWL EEKHKLQDIE AELREKYSQA KERLQRAAFA QKKRKTMTEL KENKLKDKIQ
     LLEAKIAELE IEAKHAQLSK RLRELQRRHN EFRRLLLGNQ MTSSTPLAQS LLIPNESIFS
     NIQVSEEQHQ RELCVLRRRL EELENSQQQQ LEELAAPLDR DRERLSSPRD ALPDLS