CEP95_MOUSE
ID CEP95_MOUSE Reviewed; 827 AA.
AC Q8BVV7; A2A5Z8;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Centrosomal protein of 95 kDa;
DE Short=Cep95;
DE AltName: Full=Coiled-coil domain-containing protein 45;
GN Name=Cep95; Synonyms=Ccdc45;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250}.
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DR EMBL; AK076400; BAC36324.1; -; mRNA.
DR EMBL; AL593847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL603664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466558; EDL34315.1; -; Genomic_DNA.
DR CCDS; CCDS25563.1; -.
DR RefSeq; NP_796062.2; NM_177088.3.
DR AlphaFoldDB; Q8BVV7; -.
DR SMR; Q8BVV7; -.
DR BioGRID; 235807; 1.
DR STRING; 10090.ENSMUSP00000018516; -.
DR iPTMnet; Q8BVV7; -.
DR PhosphoSitePlus; Q8BVV7; -.
DR MaxQB; Q8BVV7; -.
DR PaxDb; Q8BVV7; -.
DR PRIDE; Q8BVV7; -.
DR ProteomicsDB; 283887; -.
DR Antibodypedia; 67088; 88 antibodies from 20 providers.
DR Ensembl; ENSMUST00000018516; ENSMUSP00000018516; ENSMUSG00000018372.
DR GeneID; 320162; -.
DR KEGG; mmu:320162; -.
DR UCSC; uc007lzu.2; mouse.
DR CTD; 90799; -.
DR MGI; MGI:2443502; Cep95.
DR VEuPathDB; HostDB:ENSMUSG00000018372; -.
DR eggNOG; ENOG502QTFE; Eukaryota.
DR GeneTree; ENSGT00390000005412; -.
DR InParanoid; Q8BVV7; -.
DR OMA; KHSQPWK; -.
DR OrthoDB; 1353802at2759; -.
DR PhylomeDB; Q8BVV7; -.
DR TreeFam; TF333224; -.
DR BioGRID-ORCS; 320162; 8 hits in 73 CRISPR screens.
DR ChiTaRS; Cep95; mouse.
DR PRO; PR:Q8BVV7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BVV7; protein.
DR Bgee; ENSMUSG00000018372; Expressed in undifferentiated genital tubercle and 196 other tissues.
DR ExpressionAtlas; Q8BVV7; baseline and differential.
DR Genevisible; Q8BVV7; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR026619; CEP95.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044039; DUF5745.
DR PANTHER; PTHR22545; PTHR22545; 1.
DR Pfam; PF19016; DUF5745; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..827
FT /note="Centrosomal protein of 95 kDa"
FT /id="PRO_0000234506"
FT REGION 115..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 584..633
FT /evidence="ECO:0000255"
FT COILED 701..795
FT /evidence="ECO:0000255"
FT COMPBIAS 124..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 447
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 449
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96GE4"
FT MOD_RES 451
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96GE4"
FT CONFLICT 412
FT /note="N -> D (in Ref. 1; BAC36324)"
FT /evidence="ECO:0000305"
FT CONFLICT 456
FT /note="H -> N (in Ref. 1; BAC36324)"
FT /evidence="ECO:0000305"
FT CONFLICT 663
FT /note="Q -> P (in Ref. 1; BAC36324)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 827 AA; 95210 MW; 8E512C718DCED49B CRC64;
MASSEAEWVT IANNLLFKCH IHLRIHELQD CDANVFIALY QSILGEKVPD LIVLPRNQED
EAHNVQAVID SLALDYLQVS LSHITGENIV KGDNESIRNL LEIFDGLLDY LTEHISESSP
NKSETEQYSK DSHGEEAGED LERTEEAKWR NASFMRCSFS SDTLGPTWDE DEAESTGEII
RLGDTAHTFS QRSNGAQNSK DLRSRKASAS PGVEPPEEML NPGPLGFLSQ NGPPCEAASE
TPPMSMVPSA RKLGEPIRAA IPLHPPYHPS EPRAPCPIGK EYLWSSRYLS TPTSGEHMAP
SVEPDDAFLT STLFKDDDQE TYLPKPEATR TRKPSKGERD ENRAAIPSEH LPFSQKARKP
LTEQELHAMS EKLSQRLSEL DWMLKTALGD RGTGETDGND GDGGGEEVRS GNEEMLSQHS
DSVMEYGPKK PRPGFSTCRK APYRSHSLSP SSVNKHRQLE KEKKRQHKSK GTDSCHFQAK
ALTEAFEREL RKHKVQENVG LRGIREEEEE EEETGKSYRE VVPKGTSKRS QVQKTYSRKT
AAPSPKGDGR LKSSKASPMK VSEHSLLSLM LEQFPFLYVS DPTLTKMWKQ QMAQVEQLKR
EAQRENRSKK KLQDEIEEAL RRHDLLTALV KKEYDHNKRL QDFRDRIQRQ RLTQSKIKEN
RHQSVRARKY YDDYRVQLRA KMMKMRTREE MIFKKLFEEG LQIQKQRLRD LRNYAKEKRN
EEKRQHQNEL DSMENHYKDQ FSLLAEAISQ ERQELKVRQK FQAQTLHKVK RELRAKMEKE
IQQLQHMITQ NDDDAFFREL EAERFKARLQ LASFQYSKNP FPRGQTS
