ID   CEP95_RAT               Reviewed;         821 AA.
AC   Q5XI03;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Centrosomal protein of 95 kDa;
DE            Short=Cep95;
DE   AltName: Full=Coiled-coil domain-containing protein 45;
GN   Name=Cep95; Synonyms=Ccdc45;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}.
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DR   EMBL; BC083896; AAH83896.1; -; mRNA.
DR   RefSeq; NP_001013884.1; NM_001013862.1.
DR   AlphaFoldDB; Q5XI03; -.
DR   SMR; Q5XI03; -.
DR   STRING; 10116.ENSRNOP00000062563; -.
DR   CarbonylDB; Q5XI03; -.
DR   iPTMnet; Q5XI03; -.
DR   PhosphoSitePlus; Q5XI03; -.
DR   PaxDb; Q5XI03; -.
DR   PRIDE; Q5XI03; -.
DR   GeneID; 287766; -.
DR   KEGG; rno:287766; -.
DR   UCSC; RGD:1309655; rat.
DR   CTD; 90799; -.
DR   RGD; 1309655; Cep95.
DR   VEuPathDB; HostDB:ENSRNOG00000014354; -.
DR   eggNOG; ENOG502QTFE; Eukaryota.
DR   HOGENOM; CLU_018428_1_0_1; -.
DR   InParanoid; Q5XI03; -.
DR   OMA; KHSQPWK; -.
DR   OrthoDB; 1353802at2759; -.
DR   PRO; PR:Q5XI03; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000014354; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q5XI03; RN.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   InterPro; IPR026619; CEP95.
DR   InterPro; IPR044039; DUF5745.
DR   PANTHER; PTHR22545; PTHR22545; 1.
DR   Pfam; PF19016; DUF5745; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..821
FT                   /note="Centrosomal protein of 95 kDa"
FT                   /id="PRO_0000234507"
FT   REGION          310..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          514..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          578..627
FT                   /evidence="ECO:0000255"
FT   COILED          695..789
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        311..341
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..412
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         445
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GE4"
FT   MOD_RES         447
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GE4"
FT   MOD_RES         449
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GE4"
SQ   SEQUENCE   821 AA;  94508 MW;  DE8F6F621FFE2F05 CRC64;
     MASSEAEWVT IANNLLFKCH IHLRIHKLQD CDANVFIALY QSILGEKVPD LIVIPRSQED
     NAHNVQAVID SLALDYLQVS LSHITGENIV KGDKGSIKNL LEIFDGLLEY LTEHISESSH
     NRSASEQFCR DSRGEEPVEE LESAKESSWR KVPFMRCSFS PDALGPTWDE EEAESTGEII
     RLGDTAHTFS LRSNGAQNSM NFWSRKASTS GIRPPEEMLN PGLSSFLFKN GPTCEEEEAP
     PIHMATSARK LGEPIRAAIP LHPPYHPPEP RAPCPIGKEY LCSGHYLSTP ASGEHRAPSV
     EPGDVFLTST LCKDDDQETD LDLTESSKTR RLSKGERSEN RAVAPSEYPP FPQKARKRLT
     EQELHAMSEK LSQRLSELDW MLKTALGDRA TGEAHGKDGG AGDEEAHSAN EEMLSQHSDS
     VMEYGPRKPR PGFSMHRKAP YRSHSLSPSS VNKHRQSEKE RKKQHKSKGT DTHHFQAKAL
     TEAFERELRK NKVQENVGLR GIREEEEETE KSYKEAFAKG TTKQSQVQKI YSRKTAAPTP
     KGGLLKSSKA SPMKVNEHSL LSLMLEQFPF LYVSDPTLTK MWKQQMAQVE QLRREAQREN
     RSKKKLQDEI EEALRRHDLL TALVKKEYDH NKRLQDFKDR IHKQRLTQSK IKENRHQSVR
     ARKYYDDYRV QLRAKMMKMR TREEMIFKKL FEEGLQIQKQ RLRDLRNYAK EKRSEEKRQH
     QNELDSMENY YKDQFSLLAE AISQGRQELK ARQRSQAQTL HKVKRELRAK MEKEIEQLQH
     LITQSDDDAF FRELEAERFK ARLQLASFQY SKNPFPRGQT P