ID   CEP97_XENLA             Reviewed;         807 AA.
AC   Q6GPJ8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Centrosomal protein of 97 kDa;
DE            Short=Cep97;
DE   AltName: Full=Leucine-rich repeat and IQ domain-containing protein 2;
GN   Name=cep97; Synonyms=lrriq2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a key negative regulator of ciliogenesis in
CC       collaboration with ccp110 by capping the mother centriole thereby
CC       preventing cilia formation. Required for recruitment of ccp110 to the
CC       centrosome (By similarity). {ECO:0000250|UniProtKB:Q8IW35}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q8IW35}.
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DR   EMBL; BC073119; AAH73119.1; -; mRNA.
DR   RefSeq; NP_001085670.1; NM_001092201.1.
DR   AlphaFoldDB; Q6GPJ8; -.
DR   SMR; Q6GPJ8; -.
DR   PRIDE; Q6GPJ8; -.
DR   DNASU; 444096; -.
DR   GeneID; 444096; -.
DR   KEGG; xla:444096; -.
DR   CTD; 444096; -.
DR   Xenbase; XB-GENE-949467; cep97.L.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 444096; Expressed in testis and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS51450; LRR; 7.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..807
FT                   /note="Centrosomal protein of 97 kDa"
FT                   /id="PRO_0000263707"
FT   REPEAT          34..55
FT                   /note="LRR 1"
FT   REPEAT          56..77
FT                   /note="LRR 2"
FT   REPEAT          78..99
FT                   /note="LRR 3"
FT   REPEAT          100..121
FT                   /note="LRR 4"
FT   REPEAT          122..143
FT                   /note="LRR 5"
FT   REPEAT          144..165
FT                   /note="LRR 6"
FT   REPEAT          168..189
FT                   /note="LRR 7"
FT   DOMAIN          208..246
FT                   /note="LRRCT"
FT   DOMAIN          519..548
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          306..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          607..756
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..627
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        656..682
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        684..704
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..734
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        735..751
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   807 AA;  90057 MW;  3D642499BC397EFE CRC64;
     MAVAHLACDS QGSVVDLSGQ GLQKLSPTLP FGNDTQTLIL DKNQIIKLEH VEKCRNLVQL
     SVANNRLVRM MGVAKLIHLR VLNLPHNSIG YVEGLKDLVH LEWINLAGNN LKIIDQINSS
     TSLQHLDLSD NNISQIGDLS KLKSLKTLLL HGNNIASLRA ASACLPQSLT ILSLAENEIR
     DLNEVAFLAG LVDLEQLSIM NNPCVMATPS IPGFDYRPFI VSWCLNLKVL DGYVVSQKES
     LKAEWLYSQG KGRSYRLGQH IPLVQYLATV CPLTSAHGLQ TEEDAKLDKI LSKQRLHQKQ
     LLHQTRSDGY LTSSTPNKRL PLSTEHHSPT HVLQTEPTVQ VNNWLRSSSS EDHSYAVRNI
     CSSPFGPPHY SSLYMEDIQT DEDKLNCSLL SSESTFMPVA PGLSPVSPTV ELRVPAIKAD
     LPVNETVIEF NKDHTELPPS ETPEKPKLIP GLSAMQDDKS CCVYPVIKDE NVTENIINCE
     TAVSMESTQT SNGPTCHNLI MNCKQASVLD QDVNHINKIS KAATKLQSCW RGFYARKYNP
     KVKDVCYEIR LSRMQEHIVF LTEEVIRLRK EKEEDRIQRI LQGEAVRYLW EQVQAIQQWQ
     NTVKLQTANS SENDLPSASN SKHANPALEE LPSSPEKLNR KASPDIPDSG FHSVILNHCT
     MGNTEKNSSE ESEYSQPSLD TGRHYNDKVP DSPADQDLTR EEQSQSSKDS FTSEQDSSLL
     QQYLRSVEQL DETADNTSYS ERTEESRPEI TTCSDNSDLS CSISHFLPEN SKQENIDIHS
     NLPSIDDGHN TPIPCDSSLL VPQPDLV