CER1_CHICK
ID CER1_CHICK Reviewed; 272 AA.
AC Q9PWB0;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Cerberus;
DE Flags: Precursor;
GN Name=CER1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=10508582; DOI=10.1016/s0960-9822(99)80419-9;
RA Zhu L., Marvin M.J., Gardiner A., Lassar A.B., Mercola M., Stern C.D.,
RA Levin M.;
RT "Cerberus regulates left-right asymmetry of the embryonic head and heart.";
RL Curr. Biol. 9:931-938(1999).
CC -!- FUNCTION: Cytokine that acts as a regulator of the activity of
CC Nodal/BMP pathways during the establishment of bilateral asymmetry in
CC the head and trunk of the embryo. {ECO:0000269|PubMed:10508582}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: At embryonic stage 8 is expressed in the left
CC lateral plate mesoderm, bilaterally in the head and in a small
CC horizontal domain coincident with the second caudal somite. By stage 9,
CC expression in the right side of the head has disappeared and all
CC remaining expression in both the head and trunk is on the left. The
CC most medial domain of expression expands caudally as new somites form.
CC {ECO:0000269|PubMed:10508582}.
CC -!- INDUCTION: By SHH signaling both in the head and in the trunk. On the
CC left side in the head was also controlled by NODAL.
CC {ECO:0000269|PubMed:10508582}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000305}.
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DR EMBL; AF139721; AAD51610.1; -; mRNA.
DR AlphaFoldDB; Q9PWB0; -.
DR STRING; 9031.ENSGALP00000008711; -.
DR PaxDb; Q9PWB0; -.
DR Ensembl; ENSGALT00000008725; ENSGALP00000008711; ENSGALG00000005434.
DR VEuPathDB; HostDB:geneid_395623; -.
DR eggNOG; ENOG502S2G4; Eukaryota.
DR GeneTree; ENSGT00530000063926; -.
DR HOGENOM; CLU_104447_0_0_1; -.
DR InParanoid; Q9PWB0; -.
DR OMA; FCSHCSP; -.
DR PhylomeDB; Q9PWB0; -.
DR TreeFam; TF106445; -.
DR PRO; PR:Q9PWB0; -.
DR Proteomes; UP000000539; Chromosome Z.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0016015; F:morphogen activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0009948; P:anterior/posterior axis specification; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
DR GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; IBA:GO_Central.
DR GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; IEP:BHF-UCL.
DR GO; GO:0003419; P:growth plate cartilage chondrocyte proliferation; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IMP:BHF-UCL.
DR GO; GO:0048382; P:mesendoderm development; IEP:BHF-UCL.
DR GO; GO:1902813; P:negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry; IMP:AgBase.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:AgBase.
DR GO; GO:2000381; P:negative regulation of mesoderm development; IEA:Ensembl.
DR GO; GO:1900176; P:negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; IDA:BHF-UCL.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:AgBase.
DR GO; GO:1901207; P:regulation of heart looping; IMP:AgBase.
DR GO; GO:0035582; P:sequestering of BMP in extracellular matrix; IBA:GO_Central.
DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001657; P:ureteric bud development; IEA:Ensembl.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR016860; Cerberus.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15273; PTHR15273; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF027807; Cerberus; 1.
DR SMART; SM00041; CT; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..272
FT /note="Cerberus"
FT /id="PRO_0000006713"
FT DOMAIN 168..253
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT CARBOHYD 228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 168..215
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 182..229
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 192..245
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 196..247
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 272 AA; 31225 MW; 36E4C9F719711BCA CRC64;
MSLLLLQLLV LSCLGDTEPQ PDSQQRKRRP LQHLFYLDRN LLESQSFHEL VGENPVGVKE
TQEEPSFFIA FPQTAGESQK QGEKKMSRFI LPNAELYAHQ DLRTWAAPKE ISPVENFSPS
YYSNKRDVEP PYRKDAKKFW DHFMLRKNSA SEEVVLPIKT NEMHQETCRT LPFSQSVAHE
SCEKVIVQNN LCFGKCSSFH VPGPDDRLYT FCSKCLPTKF SMKHLDLNCT SSVPVVKKVM
IVEECNCETQ KIEDPLLGSR QSDFLGNLPE HN
