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CES2_CAEEL
ID   CES2_CAEEL              Reviewed;         211 AA.
AC   Q94126;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Transcription factor ces-2 {ECO:0000305};
DE   AltName: Full=Cell death specification protein 2 {ECO:0000312|WormBase:ZK909.4};
GN   Name=ces-2; ORFNames=ZK909.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND MUTAGENESIS OF ALA-129.
RC   STRAIN=Bristol N2;
RX   PubMed=8700229; DOI=10.1038/382545a0;
RA   Metzstein M.M., Hengartner M.O., Tsung N., Ellis R., Horvitz H.R.;
RT   "Transcriptional regulator of programmed cell death encoded by
RT   Caenorhabditis elegans gene ces-2.";
RL   Nature 382:545-547(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF ALA-129.
RX   PubMed=12231624; DOI=10.1101/gad.996302;
RA   Wang X., Chamberlin H.M.;
RT   "Multiple regulatory changes contribute to the evolution of the
RT   Caenorhabditis lin-48 ovo gene.";
RL   Genes Dev. 16:2345-2349(2002).
RN   [4]
RP   FUNCTION, DEVELOPMENTAL STAGE, AND INTERACTION WITH ATF-2.
RX   PubMed=16310763; DOI=10.1016/j.ydbio.2005.10.029;
RA   Wang X., Jia H., Chamberlin H.M.;
RT   "The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a
RT   cell-specific target gene in C. elegans.";
RL   Dev. Biol. 289:456-465(2006).
RN   [5] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=19686386; DOI=10.1111/j.1471-4159.2009.06323.x;
RA   Janssen T., Husson S.J., Meelkop E., Temmerman L., Lindemans M.,
RA   Verstraelen K., Rademakers S., Mertens I., Nitabach M., Jansen G.,
RA   Schoofs L.;
RT   "Discovery and characterization of a conserved pigment dispersing factor-
RT   like neuropeptide pathway in Caenorhabditis elegans.";
RL   J. Neurochem. 111:228-241(2009).
CC   -!- FUNCTION: Transcription factor (PubMed:8700229, PubMed:16310763).
CC       Required to activate programmed cell death in the sister cells of the
CC       serotoninergic neurosecretory motor (NSM) neurons (PubMed:8700229).
CC       Negatively regulates the activity of ces-1 which in turn negatively
CC       regulates the activities of cell-killing genes (PubMed:8700229). Binds
CC       to the DNA sequence 5'-RTTACGTAAY-3' (PubMed:8700229). Involved in the
CC       development of the excretory duct cell, by positively modulating
CC       embryonic transcription of putative transcription factor lin-48, acting
CC       in concert with NFIL3 transcription factor homolog atf-2
CC       (PubMed:16310763, PubMed:12231624). Positively modulates expression of
CC       neuropeptide pigment dispersing factor homologs pdf-1 and pdf-2
CC       (PubMed:19686386). {ECO:0000269|PubMed:16310763,
CC       ECO:0000269|PubMed:19686386, ECO:0000269|PubMed:8700229}.
CC   -!- SUBUNIT: Interacts with NFIL3 transcription factor homolog atf-2.
CC       {ECO:0000269|PubMed:16310763}.
CC   -!- INTERACTION:
CC       Q94126; Q21361: atf-2; NbExp=4; IntAct=EBI-328155, EBI-317743;
CC       Q94126; Q8IG69: cebp-2; NbExp=3; IntAct=EBI-328155, EBI-2914231;
CC       Q94126; Q94126: ces-2; NbExp=2; IntAct=EBI-328155, EBI-328155;
CC       Q94126; Q9XUK2: zip-3; NbExp=2; IntAct=EBI-328155, EBI-322774;
CC       Q94126; Q9NAE4: zip-7; NbExp=4; IntAct=EBI-328155, EBI-332523;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expression begins in the embryo and diminishes in
CC       larvae (PubMed:16310763). Expressed in the excretory duct cell, as well
CC       as other cells, at larval L3 stage (PubMed:16310763).
CC       {ECO:0000269|PubMed:16310763}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes morphological
CC       defects in excretory duct cells. Reduces expression of transcription
CC       factor lin-48. {ECO:0000269|PubMed:12231624}.
CC   -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR   EMBL; U60979; AAC47277.1; -; Genomic_DNA.
DR   EMBL; Z82096; CAB05032.1; -; Genomic_DNA.
DR   PIR; T28098; T28098.
DR   RefSeq; NP_493610.1; NM_061209.5.
DR   AlphaFoldDB; Q94126; -.
DR   SMR; Q94126; -.
DR   BioGRID; 38746; 19.
DR   DIP; DIP-27195N; -.
DR   IntAct; Q94126; 20.
DR   STRING; 6239.ZK909.4; -.
DR   EPD; Q94126; -.
DR   PaxDb; Q94126; -.
DR   EnsemblMetazoa; ZK909.4.1; ZK909.4.1; WBGene00000469.
DR   GeneID; 173365; -.
DR   KEGG; cel:CELE_ZK909.4; -.
DR   UCSC; ZK909.4; c. elegans.
DR   CTD; 173365; -.
DR   WormBase; ZK909.4; CE15479; WBGene00000469; ces-2.
DR   eggNOG; KOG3119; Eukaryota.
DR   HOGENOM; CLU_1327470_0_0_1; -.
DR   InParanoid; Q94126; -.
DR   OMA; CENNHEE; -.
DR   OrthoDB; 1500131at2759; -.
DR   SignaLink; Q94126; -.
DR   PRO; PR:Q94126; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00000469; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:WormBase.
DR   GO; GO:0007568; P:aging; IMP:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IMP:WormBase.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IMP:WormBase.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR040223; PAR_bZIP.
DR   PANTHER; PTHR11988; PTHR11988; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..211
FT                   /note="Transcription factor ces-2"
FT                   /id="PRO_0000076638"
FT   DOMAIN          116..179
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          83..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..140
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          144..172
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          184..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..152
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..211
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         129
FT                   /note="A->T: In n732; defects in programmed cell death in
FT                   the sister cells of the serotoninergic neurosecretory motor
FT                   (NSM) neurons. Morphological defects in excretory duct
FT                   cells. Reduced expression of transcription factor lin-48."
FT                   /evidence="ECO:0000269|PubMed:12231624,
FT                   ECO:0000269|PubMed:8700229"
SQ   SEQUENCE   211 AA;  23133 MW;  A791D04893FC67A0 CRC64;
     MDFHRALSAL FTNQAAVQPL LGSLGFPFND GTSILTTALA AQSGGKKLDT PLGILPFDSL
     PTTNLLTPTK KIKLEDELCA SPVSSRSSTV SSSHFSSPQR SPSRKMSVPI PEEKKDSAYF
     ERRRKNNDAA KRSRDARRQK EEQIASKAHA LERENMQLRG KVSSLEQEAA QLRFLLFSKI
     SPANSEVSCE SNDSTETNDS NDSKSDSTIE V
 
 
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