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CESA2_ORYSJ
ID   CESA2_ORYSJ             Reviewed;        1073 AA.
AC   Q84M43; A0A0P0W503;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Probable cellulose synthase A catalytic subunit 2 [UDP-forming];
DE            EC=2.4.1.12;
DE   AltName: Full=OsCesA2;
GN   Name=CESA2; OrderedLocusNames=Os03g0808100, LOC_Os03g59340;
GN   ORFNames=OsJ_012480, OSJNBa0059E14.5, OSJNBa0060M17.2;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Probable catalytic subunit of cellulose synthase terminal
CC       complexes ('rosettes'), required for beta-1,4-glucan microfibril
CC       crystallization, a major mechanism of the cell wall formation.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-
CC         beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:19929, Rhea:RHEA-
CC         COMP:10033, Rhea:RHEA-COMP:10034, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:18246, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.12;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC   -!- PATHWAY: Glycan metabolism; plant cellulose biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. Plant
CC       cellulose synthase subfamily. {ECO:0000305}.
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DR   EMBL; AC135958; AAP21426.1; -; Genomic_DNA.
DR   EMBL; AC145384; AAS07381.1; -; Genomic_DNA.
DR   EMBL; DP000009; ABF99460.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF13562.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS86968.1; -; Genomic_DNA.
DR   EMBL; CM000140; EAZ28997.1; -; Genomic_DNA.
DR   EMBL; AK069196; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015630545.1; XM_015775059.1.
DR   AlphaFoldDB; Q84M43; -.
DR   SMR; Q84M43; -.
DR   STRING; 4530.OS03T0808100-01; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   PaxDb; Q84M43; -.
DR   PRIDE; Q84M43; -.
DR   EnsemblPlants; Os03t0808100-01; Os03t0808100-01; Os03g0808100.
DR   GeneID; 4334515; -.
DR   Gramene; Os03t0808100-01; Os03t0808100-01; Os03g0808100.
DR   KEGG; osa:4334515; -.
DR   eggNOG; ENOG502QSUQ; Eukaryota.
DR   HOGENOM; CLU_001418_0_1_1; -.
DR   InParanoid; Q84M43; -.
DR   OMA; EIPRVYI; -.
DR   OrthoDB; 679241at2759; -.
DR   PlantReactome; R-OSA-1119314; Cellulose biosynthesis.
DR   UniPathway; UPA00695; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000007752; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   ExpressionAtlas; Q84M43; baseline and differential.
DR   Genevisible; Q84M43; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016760; F:cellulose synthase (UDP-forming) activity; IEA:UniProtKB-EC.
DR   GO; GO:0016759; F:cellulose synthase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009833; P:plant-type primary cell wall biogenesis; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005150; Cellulose_synth.
DR   InterPro; IPR027934; CES_Znf_RING.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF03552; Cellulose_synt; 1.
DR   Pfam; PF14569; zf-UDP; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell wall biogenesis/degradation; Cellulose biosynthesis;
KW   Coiled coil; Glycosyltransferase; Membrane; Metal-binding;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..1073
FT                   /note="Probable cellulose synthase A catalytic subunit 2
FT                   [UDP-forming]"
FT                   /id="PRO_0000319360"
FT   TOPO_DOM        1..270
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..293
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        315..856
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        857..877
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        878..882
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        883..903
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        904..918
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        919..939
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        940..969
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        970..990
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        991..1001
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1002..1022
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1023..1031
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1032..1052
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1053..1073
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         13..59
FT                   /note="RING-type; degenerate"
FT   REGION          66..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          655..676
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          443..470
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        389
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        773
FT                   /evidence="ECO:0000255"
FT   BINDING         13
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SWW6"
FT   BINDING         16
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SWW6"
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SWW6"
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SWW6"
FT   BINDING         40
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SWW6"
FT   BINDING         43
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SWW6"
FT   BINDING         55
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SWW6"
FT   BINDING         58
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SWW6"
FT   BINDING         555
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255"
FT   BINDING         557
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        211
FT                   /note="K -> E (in Ref. 6; AK069196)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1073 AA;  120682 MW;  55B677033E77A7BE CRC64;
     MDGAKSGKQC HVCQICGDGV GTAADGELFT ACDVCGFPVC RPCYEYERKD GSQACPQCKT
     KYKRHKGSPP ILGDESDDVD ADDASDVNYP TSGNQDHKHK IAERMLTWRM NSGRNDDIVH
     SKYDSGEIGH PKYDSGEIPR IYIPSLTHSQ ISGEIPGASP DHMMSPVGNI GRRGHPFPYV
     NHSPNPSREF SGSLGNVAWK ERVDGWKMKD KGAIPMANGT SIAPSEGRGV GDIDASTDYN
     MEDALLNDET RQPLSRKVPI SSSRINPYRM VIVLRLIVLC IFLHYRITNP VRNAYPLWLL
     SVICEIWFAL SWILDQFPKW SPINRETYLD RLALRYDREG EPSQLAPVDI FVSTVDPMKE
     PPLVTANTVL SILAVDYPVD KVSCYVSDDG AAMLTFDALA ETSEFARKWV PFCKKYSIEP
     RAPEWYFAQK IDYLKDKVQA SFVKDRRAMK REYEEFKVRV NALVAKAQKV PEEGWIMQDG
     TPWPGNNTRD HPGMIQVFLG HSGGLDTEGN ELPRLVYVSR EKRPGFQHHK KAGAMNALVR
     VSAVLTNGQY LLNLDCDHYI NNSKALREAM CFLMDPNLGR RVCYVQFPQR FDGIDRNDRY
     ANRNTVFFDI NLRGLDGLQG PVYVGTGCVF NRTALYGYEP PIKQKRPGYF SSLCGGRKKT
     KKSKEKSTEK KKSHKHVDSS VPVFNLEDIE EGIEGSGFDD EKSLLMSQMS LEKRFGQSSV
     FVASTLMEYG GVPQSATPES LLKEAIHVIS CGYEDKSDWG TEIGWIYGSV TEDILTGFKM
     HARGWRSIYC MPKRPAFKGS APINLSDRLN QVLRWALGSV EILFSRHCPI WYGYGGRLKF
     LERFAYINTT IYPLTSIPLL LYCILPAICL LTGKFIIPEI SNFASIWFIS LFLSIFATGI
     LEMRWSGVGI DEWWRNEQFW VIGGISAHLF AVFQGLLKVL AGIDTSFTVT SKASDEEGDF
     AELYMFKWTT LLIPPTTILI INLVGVVAGI SYAINSGYQS WGPLFGKLFF AFWVIVHLYP
     FLKGLMGRQN RTPTIVVVWA ILLASIFSLL WVRIDPFTTR VTGPDTQKCG INC
 
 
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