ID   CESS1_CONMO             Reviewed;         125 AA.
AC   A0A291NVT7;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2017, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Conopressin-conophysin, isoform 1 {ECO:0000303|PubMed:32058072};
DE   Contains:
DE     RecName: Full=Conopressin-E {ECO:0000303|PubMed:32058072};
DE   Contains:
DE     RecName: Full=Conophysin {ECO:0000303|PubMed:32058072};
DE   Flags: Precursor; Fragment;
OS   Conus monile (Necklace cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX   NCBI_TaxID=351660;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-31 AND 65-86, AMIDATION
RP   AT GLY-31, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION,
RP   SYNTHESIS OF 23-31, AND NOMENCLATURE.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=32058072; DOI=10.1016/j.bbapap.2020.140391;
RA   Kumar S., Vijayasarathy M., Venkatesha M.A., Sunita P., Balaram P.;
RT   "Cone snail analogs of the pituitary hormones oxytocin/vasopressin and
RT   their carrier protein neurophysin. Proteomic and transcriptomic
RT   identification of conopressins and conophysins.";
RL   Biochim. Biophys. Acta 1868:140391-140391(2020).
CC   -!- FUNCTION: Targets vasopressin-oxytocin related receptors.
CC       {ECO:0000250|UniProtKB:P05486}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:32058072}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:32058072}.
CC   -!- DOMAIN: The cysteine framework of the conopressin is C-C.
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: [Conopressin-E]: Mass=1034.46; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:32058072};
CC   -!- MISCELLANEOUS: The letter 'E' in the name 'Conopressin-E' proposed by
CC       Kumar and colleagues stands for the eighth residue, which differs
CC       between conopressins. {ECO:0000305|PubMed:32058072}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; KY982973; ATJ04134.1; -; mRNA.
DR   AlphaFoldDB; A0A291NVT7; -.
DR   SMR; A0A291NVT7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   G-protein coupled receptor impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          <1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..125
FT                   /note="Conopressin-conophysin, isoform 1"
FT                   /id="PRO_5012674281"
FT   PEPTIDE         23..31
FT                   /note="Conopressin-E"
FT                   /evidence="ECO:0000269|PubMed:32058072"
FT                   /id="PRO_0000450735"
FT   PROPEP          32..39
FT                   /evidence="ECO:0000250|UniProtKB:P05486"
FT                   /id="PRO_0000450736"
FT   CHAIN           40..125
FT                   /note="Conophysin"
FT                   /evidence="ECO:0000250|UniProtKB:P05486"
FT                   /id="PRO_0000450737"
FT   MOD_RES         31
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:32058072"
FT   DISULFID        23..28
FT                   /evidence="ECO:0000250|UniProtKB:P05486"
FT   DISULFID        45..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        48..59
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        53..75
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        60..65
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        92..112
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        104..124
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        113..118
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   125 AA;  13425 MW;  06B7483A169FCAAD CRC64;
     MQMGRPTLLP CLLLLLVLST QACFIRNCPE GGKRDVHMIQ PTKPCMNCSF GQCVGPRVCC
     GAGRCEIGST EADRCEEENE DPVPCKVLGQ HCVLNNPGNV NGNCVDGGIG ICCVDDTCAI
     HRRCD