CESSD_CONBY
ID CESSD_CONBY Reviewed; 144 AA.
AC P0DTJ3;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 1.
DT 03-AUG-2022, entry version 3.
DE RecName: Full=Conopressin-conophysin {ECO:0000303|PubMed:33916793};
DE Contains:
DE RecName: Full=Conopressin-ba1d {ECO:0000303|PubMed:33916793};
DE AltName: Full=Conopressin ba2 {ECO:0000305};
DE Contains:
DE RecName: Full=Conophysin ba2 {ECO:0000305};
DE Flags: Precursor;
OS Conus bayani (Bayan's cone) (Stellaconus bayani).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Splinoconus.
OX NCBI_TaxID=2070216;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom, and Venom duct;
RX PubMed=33916793; DOI=10.3390/md19040202;
RA Rajaian Pushpabai R., Wilson Alphonse C.R., Mani R., Arun Apte D.,
RA Franklin J.B.;
RT "Diversity of Conopeptides and Conoenzymes from the Venom Duct of the
RT Marine Cone Snail Conus bayani as Determined from Transcriptomic and
RT Proteomic Analyses.";
RL Mar. Drugs 19:0-0(2021).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33916793}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:33916793}.
CC -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: [Conopressin-ba1d]: Mass=881.2; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:33916793};
CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.9.10; -; 1.
DR InterPro; IPR000981; Neurhyp_horm.
DR InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR PANTHER; PTHR11681; PTHR11681; 1.
DR Pfam; PF00184; Hormone_5; 1.
DR SMART; SM00003; NH; 1.
DR SUPFAM; SSF49606; SSF49606; 1.
PE 1: Evidence at protein level;
KW Amidation; Disulfide bond; Secreted; Signal; Toxin.
FT SIGNAL 1..27
FT /evidence="ECO:0000305|PubMed:33916793"
FT PEPTIDE 28..36
FT /note="Conopressin-ba1d"
FT /evidence="ECO:0000250|UniProtKB:P05486, ECO:0000305"
FT /id="PRO_0000454979"
FT PEPTIDE 28..35
FT /note="Conopressin-ba1d"
FT /evidence="ECO:0000269|PubMed:33916793"
FT /id="PRO_0000454980"
FT PROPEP 37..44
FT /evidence="ECO:0000250|UniProtKB:P05486"
FT /id="PRO_0000454981"
FT CHAIN 45..130
FT /note="Conophysin ba2"
FT /evidence="ECO:0000250|UniProtKB:P05486"
FT /id="PRO_0000454982"
FT PROPEP 131..144
FT /evidence="ECO:0000305"
FT /id="PRO_0000454983"
FT MOD_RES 36
FT /note="Aspartic acid 1-amide"
FT /evidence="ECO:0000305"
FT DISULFID 28..33
FT /evidence="ECO:0000250|UniProtKB:P05486"
FT DISULFID 50..90
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 53..64
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 58..80
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 65..70
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 97..117
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 109..129
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 118..123
FT /evidence="ECO:0000250|UniProtKB:P01175"
SQ SEQUENCE 144 AA; 15565 MW; B05F3009B89998AF CRC64;
MTRSALQMGR LTLVLCLLLQ LVLVTQACFL GNCLNDGERD VDGREAMRPC KYCSFGQCVG
PQICCGDRGC EMGSEEANKC REEDEDSTPC QVFGWPCTLN NPGNTNGKCV ANCIGICCVT
DTCVVSSECQ KESKSGIRVG CQRS
