ID   CEST_ECO11              Reviewed;         156 AA.
AC   O30999;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Tir chaperone;
GN   Name=cesT;
OS   Escherichia coli O111:H-.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=168927;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9529069; DOI=10.1128/iai.66.4.1467-1472.1998;
RA   Voss E., Paton A.W., Manning P.A., Paton J.C.;
RT   "Molecular analysis of Shiga toxigenic Escherichia coli O111:H-proteins
RT   which react with sera from patients with hemolytic-uremic syndrome.";
RL   Infect. Immun. 66:1467-1472(1998).
CC   -!- FUNCTION: Chaperone for the type III secretion of Tir. Probably
CC       stabilizes the protein, prevents inappropriate protein-
CC       proteininteractions and aids in secretion (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CesT/SycH chaperone family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF025311; AAC69246.1; -; Genomic_DNA.
DR   RefSeq; WP_000098792.1; NZ_QMIB01000037.1.
DR   AlphaFoldDB; O30999; -.
DR   BMRB; O30999; -.
DR   SMR; O30999; -.
DR   OMA; TNDEYMM; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR   InterPro; IPR010261; Tir_chaperone.
DR   Pfam; PF05932; CesT; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Virulence.
FT   CHAIN           1..156
FT                   /note="Tir chaperone"
FT                   /id="PRO_0000216360"
SQ   SEQUENCE   156 AA;  17680 MW;  DCC2C809D477B8F4 CRC64;
     MSSRSELLLD RFAEKIGVGS ISFNENRLCS FAIDEIYYIS LSDASDEYMM IYGVCGKFPT
     DNPNFALEIL NANLWFAENG GPYLCYESGA QSLLLALRFP LDDATPEKLE NEIEVVVKSM
     ENLYLVLHNQ GITLENEHMK IEEISSSDNK HYYAGR