CETA_EMENI
ID CETA_EMENI Reviewed; 176 AA.
AC C8VIP3; Q5B8Q1;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Secreted thaumatin-like protein cetA {ECO:0000303|PubMed:12409104};
DE AltName: Full=Conidial-enriched transcript protein A {ECO:0000303|PubMed:12409104};
DE Flags: Precursor;
GN Name=cetA {ECO:0000303|PubMed:12409104}; ORFNames=ANIA_03079;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [3]
RP IDENTIFICATION, AND INDUCTION.
RX PubMed=12409104; DOI=10.1016/s1087-1845(02)00502-9;
RA Osherov N., Mathew J., Romans A., May G.S.;
RT "Identification of conidial-enriched transcripts in Aspergillus nidulans
RT using suppression subtractive hybridization.";
RL Fungal Genet. Biol. 37:197-204(2002).
RN [4]
RP INDUCTION, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=16376592; DOI=10.1016/j.fgb.2005.10.001;
RA Greenstein S., Shadkchan Y., Jadoun J., Sharon C., Markovich S.,
RA Osherov N.;
RT "Analysis of the Aspergillus nidulans thaumatin-like cetA gene and evidence
RT for transcriptional repression of pyr4 expression in the cetA-disrupted
RT strain.";
RL Fungal Genet. Biol. 43:42-53(2006).
RN [5]
RP INDUCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=17703972; DOI=10.1016/j.fgb.2007.07.005;
RA Belaish R., Sharon H., Levdansky E., Greenstein S., Shadkchan Y.,
RA Osherov N.;
RT "The Aspergillus nidulans cetA and calA genes are involved in conidial
RT germination and cell wall morphogenesis.";
RL Fungal Genet. Biol. 45:232-242(2008).
CC -!- FUNCTION: Secreted thaumatin-like protein that, with calA, plays an
CC essential role in early conidial germination with a possible role in
CC cell wall remodeling (PubMed:16376592, PubMed:17703972).
CC {ECO:0000269|PubMed:16376592, ECO:0000269|PubMed:17703972}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16376592,
CC ECO:0000269|PubMed:17703972}. Secreted, extracellular space,
CC extracellular matrix {ECO:0000269|PubMed:17703972}. Secreted, cell wall
CC {ECO:0000269|PubMed:17703972}. Note=Present in the cell walls of the
CC germinating conidia but not in the germtubes (PubMed:17703972).
CC {ECO:0000269|PubMed:17703972}.
CC -!- INDUCTION: Expression is inhibited by PKA activity and is subject to
CC glucose repression (PubMed:17703972). Expressed primarily in conidia
CC (PubMed:12409104). Expressed and secreted during germination and early
CC growth (PubMed:16376592, PubMed:17703972).
CC {ECO:0000269|PubMed:12409104, ECO:0000269|PubMed:16376592,
CC ECO:0000269|PubMed:17703972}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. The double deletion of cetA
CC and calA results in cell wall defects and lyse during germination,
CC leading to the inhibition of germination (PubMed:17703972).
CC {ECO:0000269|PubMed:17703972}.
CC -!- SIMILARITY: Belongs to the thaumatin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAA63650.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BN001306; CBF83446.1; -; Genomic_DNA.
DR EMBL; AACD01000051; EAA63650.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_660683.1; XM_655591.1.
DR AlphaFoldDB; C8VIP3; -.
DR SMR; C8VIP3; -.
DR EnsemblFungi; CBF83446; CBF83446; ANIA_03079.
DR EnsemblFungi; EAA63650; EAA63650; AN3079.2.
DR GeneID; 2874209; -.
DR KEGG; ani:AN3079.2; -.
DR VEuPathDB; FungiDB:AN3079; -.
DR eggNOG; ENOG502SSWE; Eukaryota.
DR HOGENOM; CLU_083650_2_1_1; -.
DR InParanoid; C8VIP3; -.
DR OMA; CPKAICK; -.
DR OrthoDB; 1403534at2759; -.
DR Proteomes; UP000000560; Chromosome VI.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR037176; Osmotin/thaumatin-like_sf.
DR SUPFAM; SSF49870; SSF49870; 1.
PE 2: Evidence at transcript level;
KW Cell wall; Disulfide bond; Extracellular matrix; Germination;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..176
FT /note="Secreted thaumatin-like protein cetA"
FT /id="PRO_5002991596"
FT DISULFID 136..164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699"
FT DISULFID 141..148
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699"
SQ SEQUENCE 176 AA; 18572 MW; 027D974BA2BD9590 CRC64;
MMFTKALVAA TLATLTAALP QPTVVRREGG DAGVTIVNNM DSDVYAWSVT DGVSKMHTLS
SGGGSYTENF QANPNGGGVS IKLSTHQDQT DVLQFEYTKS GETIFWDMSC IDMDRAASTF
TKNGFDVSPS QTSGDCPAVN CHAGDTSCAE AYLQPKDDHA THGCPIDTSF TLTLGA
