CETP_CHICK
ID CETP_CHICK Reviewed; 505 AA.
AC Q3V6R6;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Cholesteryl ester transfer protein {ECO:0000303|PubMed:17574888};
DE Flags: Precursor;
GN Name=CETP {ECO:0000305};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RX PubMed=17574888; DOI=10.1016/j.cbpb.2007.05.003;
RA Sato K., Ohuchi A., Sato T., Schneider W.J., Akiba Y.;
RT "Molecular characterization and expression of the cholesteryl ester
RT transfer protein gene in chickens.";
RL Comp. Biochem. Physiol. 148B:117-123(2007).
CC -!- FUNCTION: Involved in the transfer of neutral lipids, including
CC cholesteryl ester and triglyceride, among lipoprotein particles. Allows
CC the net movement of cholesteryl ester from high density
CC lipoproteins/HDL to triglyceride-rich very low density
CC lipoproteins/VLDL, and the equimolar transport of triglyceride from
CC VLDL to HDL (PubMed:17574888). Regulates the reverse cholesterol
CC transport, by which excess cholesterol is removed from peripheral
CC tissues and returned to the liver for elimination (By similarity).
CC {ECO:0000250|UniProtKB:P11597, ECO:0000269|PubMed:17574888}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-
CC octadecenoate)(out); Xref=Rhea:RHEA:43348, ChEBI:CHEBI:46898;
CC Evidence={ECO:0000250|UniProtKB:P11597};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-
CC octadecenoyl)-glycerol(out); Xref=Rhea:RHEA:43352, ChEBI:CHEBI:53753;
CC Evidence={ECO:0000250|UniProtKB:P11597};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl
CC (9Z,12Z)-octadecadienoate(out); Xref=Rhea:RHEA:43356,
CC ChEBI:CHEBI:41509; Evidence={ECO:0000250|UniProtKB:P11597};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11597}.
CC Note=Secreted in plasma. {ECO:0000250|UniProtKB:P11597}.
CC -!- TISSUE SPECIFICITY: Highly expressed in liver brain, heart, and spleen.
CC Secreted in plasma. {ECO:0000269|PubMed:17574888}.
CC -!- DEVELOPMENTAL STAGE: Expression is significantly lower in mature (egg-
CC laying) females than in immature female, but unaffected by age in
CC males. {ECO:0000269|PubMed:17574888}.
CC -!- INDUCTION: Expression increases following dietary supplementation with
CC cholesterol. Expression decreases following dietary supplementation
CC with estradiol. {ECO:0000269|PubMed:17574888}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000305}.
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DR EMBL; AB205527; BAE43960.1; -; mRNA.
DR AlphaFoldDB; Q3V6R6; -.
DR SMR; Q3V6R6; -.
DR STRING; 9031.ENSGALP00000001869; -.
DR PaxDb; Q3V6R6; -.
DR VEuPathDB; HostDB:geneid_415645; -.
DR eggNOG; KOG4160; Eukaryota.
DR InParanoid; Q3V6R6; -.
DR PhylomeDB; Q3V6R6; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:InterPro.
DR GO; GO:0120020; F:cholesterol transfer activity; ISS:UniProtKB.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0030301; P:cholesterol transport; ISS:UniProtKB.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; ISS:UniProtKB.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:InterPro.
DR GO; GO:0034197; P:triglyceride transport; ISS:UniProtKB.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; ISS:UniProtKB.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR017130; Cholesteryl_ester_transfer.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47616; PTHR47616; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR PIRSF; PIRSF037185; Cholesteryl_ester_transf; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; SSF55394; 2.
PE 2: Evidence at transcript level;
KW Cholesterol metabolism; Disulfide bond; Glycoprotein; Lipid metabolism;
KW Lipid transport; Reference proteome; Secreted; Signal; Steroid metabolism;
KW Sterol metabolism; Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..505
FT /note="Cholesteryl ester transfer protein"
FT /evidence="ECO:0000250"
FT /id="PRO_0000394151"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 422
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..210
FT /evidence="ECO:0000250|UniProtKB:P11597"
SQ SEQUENCE 505 AA; 56716 MW; 0957AA18588224DD CRC64;
MLWAGGMRLG MARILLMLVH AAAACEFGPM PYSVTGIVFR MTKPAALLLN QETARLIQAS
FKHAKFPNIT GERSMRFLGT VAYTLANIQV SDLSIEQSEV ELKENDAIDI AIKNVTAFFR
GTLTYGYAGA WFLQLFHSVD FEIQSSIDLQ INIKLLCQEE QVAADASDCY LSFHKLMLHL
QGDKEPGWLK QLFTDFISFT LKFVLKRELC KEINLLAQVM ANFVHNVAEN FVQDEAIGLD
ISLASDPLIK ANYLESHHEG LVLYKNYSDV LSDSVFSPSL LSESRMLYFW ISEHILNSLA
SAAFLDGRLV LAIRGEKLQA LFEFEDTEAQ QKAVHLIFQG NSYNDSVAKV WSLALPEISL
QPEGTVVKSL VAVEISIFPP GEEPLTALYM EEEITVTIQA AYVEKKLILR PVDSQIEFKV
FNCTADPSGN DQSVRNFLQK MISAVGIPEV ISKIEPALTS LMNSKGLHLF EIKNPEIITR
KRYLIVQLDF SFPNHLLLDF LEKTL
