ID   CETP_MESAU              Reviewed;         289 AA.
AC   P25914;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Cholesteryl ester transfer protein {ECO:0000303|PubMed:1999438};
DE   AltName: Full=Lipid transfer protein I {ECO:0000305|PubMed:1999438};
DE   Flags: Fragment;
GN   Name=CETP {ECO:0000303|PubMed:1999438};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=1999438; DOI=10.1016/s0021-9258(20)64369-1;
RA   Jiang X.C., Moulin P., Quinet E., Goldberg I.J., Yacoub L.K., Agellon L.B.,
RA   Compton D., Schnitzer-Polokoff R., Tall A.R.;
RT   "Mammalian adipose tissue and muscle are major sources of lipid transfer
RT   protein mRNA.";
RL   J. Biol. Chem. 266:4631-4639(1991).
CC   -!- FUNCTION: Involved in the transfer of neutral lipids, including
CC       cholesteryl ester and triglyceride, among lipoprotein particles. Allows
CC       the net movement of cholesteryl ester from high density
CC       lipoproteins/HDL to triglyceride-rich very low density
CC       lipoproteins/VLDL, and the equimolar transport of triglyceride from
CC       VLDL to HDL. Regulates the reverse cholesterol transport, by which
CC       excess cholesterol is removed from peripheral tissues and returned to
CC       the liver for elimination. {ECO:0000250|UniProtKB:P11597}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-
CC         octadecenoate)(out); Xref=Rhea:RHEA:43348, ChEBI:CHEBI:46898;
CC         Evidence={ECO:0000250|UniProtKB:P11597};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-
CC         octadecenoyl)-glycerol(out); Xref=Rhea:RHEA:43352, ChEBI:CHEBI:53753;
CC         Evidence={ECO:0000250|UniProtKB:P11597};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl
CC         (9Z,12Z)-octadecadienoate(out); Xref=Rhea:RHEA:43356,
CC         ChEBI:CHEBI:41509; Evidence={ECO:0000250|UniProtKB:P11597};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11597}.
CC       Note=Secreted in plasma. {ECO:0000250|UniProtKB:P11597}.
CC   -!- TISSUE SPECIFICITY: Expressed in adipose tissue, heart, and skeletal
CC       muscle and to a lower extent in stomach, testis, spleen, and liver.
CC       {ECO:0000269|PubMed:1999438}.
CC   -!- INDUCTION: Up-regulated by cholesterol-rich diet.
CC       {ECO:0000269|PubMed:1999438}.
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC       {ECO:0000305}.
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DR   EMBL; M63992; AAA37066.1; -; mRNA.
DR   PIR; A38700; A38700.
DR   AlphaFoldDB; P25914; -.
DR   SMR; P25914; -.
DR   STRING; 10036.XP_005078666.1; -.
DR   eggNOG; KOG4160; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:InterPro.
DR   GO; GO:0120020; F:cholesterol transfer activity; ISS:UniProtKB.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0030301; P:cholesterol transport; ISS:UniProtKB.
DR   GO; GO:0034375; P:high-density lipoprotein particle remodeling; ISS:UniProtKB.
DR   GO; GO:0043691; P:reverse cholesterol transport; IEA:InterPro.
DR   GO; GO:0034197; P:triglyceride transport; ISS:UniProtKB.
DR   GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; ISS:UniProtKB.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR017130; Cholesteryl_ester_transfer.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   PANTHER; PTHR47616; PTHR47616; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SMART; SM00329; BPI2; 1.
DR   SUPFAM; SSF55394; SSF55394; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; Glycoprotein; Lipid metabolism; Lipid transport;
KW   Reference proteome; Secreted; Steroid metabolism; Sterol metabolism;
KW   Transport.
FT   CHAIN           <1..289
FT                   /note="Cholesteryl ester transfer protein"
FT                   /id="PRO_0000089158"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   289 AA;  32330 MW;  CA91A06D83927747 CRC64;
     NVISNIMADF VQTRAASIIS DRDVEVDISL TRSPVITATH LESHHKGHFV YKNISEDLPL
     PAFSPTLLGD TRMLYFWFSE QVLDSLAKVA FQDGRLQLSL AEAEFRAVLE TWHFNPNQEI
     IPELFSASLT SPGRVTVHCP GRPTISCQNK GVVVSSPVVI EFLFPHKDGQ DSVTHTFEED
     IVTTIQASYS KKKLFLSLSD FQIKPKMASN MDEDSASIQS FLQLMITTVG IPEVMSRLEV
     ALTTLINSKG LDLFDIINPE IISRDGFLLL QMDFGFPEHL LVDFLQSLN