ID   CETZ6_HALVD             Reviewed;         370 AA.
AC   D4GU81;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Tubulin-like protein CetZ6 {ECO:0000305};
DE   AltName: Full=Cell-structure-related euryarchaeota tubulin/FtsZ homolog 6 {ECO:0000303|PubMed:25533961};
GN   Name=cetZ6 {ECO:0000303|PubMed:25533961};
GN   Synonyms=ftsZ8 {ECO:0000312|EMBL:ADE04865.1};
GN   OrderedLocusNames=HVO_2068 {ECO:0000312|EMBL:ADE04865.1};
GN   ORFNames=C498_05628 {ECO:0000312|EMBL:ELY33662.1};
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=25533961; DOI=10.1038/nature13983;
RA   Duggin I.G., Aylett C.H., Walsh J.C., Michie K.A., Wang Q., Turnbull L.,
RA   Dawson E.M., Harry E.J., Whitchurch C.B., Amos L.A., Loewe J.;
RT   "CetZ tubulin-like proteins control archaeal cell shape.";
RL   Nature 519:362-365(2015).
CC   -!- FUNCTION: Involved in cell shape control. {ECO:0000255|HAMAP-
CC       Rule:MF_01946}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01946}.
CC   -!- DISRUPTION PHENOTYPE: Does not affect motility. No differences in
CC       growth rate or cell size. {ECO:0000269|PubMed:25533961}.
CC   -!- SIMILARITY: Belongs to the CetZ family. {ECO:0000255|HAMAP-
CC       Rule:MF_01946, ECO:0000305}.
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DR   EMBL; CP001956; ADE04865.1; -; Genomic_DNA.
DR   EMBL; AOHU01000040; ELY33662.1; -; Genomic_DNA.
DR   RefSeq; WP_004041953.1; NZ_AOHU01000040.1.
DR   AlphaFoldDB; D4GU81; -.
DR   SMR; D4GU81; -.
DR   STRING; 309800.C498_05628; -.
DR   EnsemblBacteria; ADE04865; ADE04865; HVO_2068.
DR   EnsemblBacteria; ELY33662; ELY33662; C498_05628.
DR   GeneID; 8926262; -.
DR   KEGG; hvo:HVO_2068; -.
DR   PATRIC; fig|309800.29.peg.1093; -.
DR   eggNOG; arCOG02202; Archaea.
DR   HOGENOM; CLU_058152_0_0_2; -.
DR   OMA; YNAVETT; -.
DR   OrthoDB; 23481at2157; -.
DR   Proteomes; UP000008243; Chromosome.
DR   Proteomes; UP000011532; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1330.20; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   HAMAP; MF_01946; CetZ; 1.
DR   InterPro; IPR032907; CetZ.
DR   InterPro; IPR045061; FtsZ/CetZ.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR30314; PTHR30314; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   SMART; SM00864; Tubulin; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
PE   3: Inferred from homology;
KW   Cell shape; Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..370
FT                   /note="Tubulin-like protein CetZ6"
FT                   /id="PRO_0000432188"
FT   BINDING         110..112
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01946"
FT   BINDING         189
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01946"
SQ   SEQUENCE   370 AA;  38734 MW;  73628395863DF3C9 CRC64;
     MNVFCFGAGK AGGRVVEQLL EYERQRNPDF ISGAAACDTT AADLDALELI PEDARALFGA
     TETNGQGFDG DAERGAAAAA DEHRKLLEPT DDAPIAASDA FVVCAGLGGG TGGPTAAVLA
     ERLSEVYDQP VYGVGIFSTA TTDQQHASNT LRSLRQLVSK TDHVFGFDTA AWVKNEDEPI
     SDEAYDTLNA ELARRLGTLF AAGEVTTADD VGASVVDASE IMNTLRGGGL ATLGYSERPL
     PPRDTSVVGR LKRLVGDDAE SVDQIDSLNR ITTQTREAVR GQLTLSCDIG SASRGLLVIT
     GRPAWLNRDA ISQNQGWIEE QTGSLEVRNG DDPRPDADAL SVLVLLGGIN PTAQLTALQA
     VADAGDSGDA