CEX2_CAEEL
ID CEX2_CAEEL Reviewed; 189 AA.
AC P45961; Q56DS6; Q7JMP5;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Calexcitin-2;
GN Name=cex-2; ORFNames=T09A5.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RA Ly S., Baylis H.A., Walker D.S.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P45961-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P45961-2; Sequence=VSP_032764, VSP_032765;
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DR EMBL; AY962814; AAX81435.1; -; mRNA.
DR EMBL; Z36753; CAA85340.3; -; Genomic_DNA.
DR EMBL; Z36753; CAE48510.2; -; Genomic_DNA.
DR PIR; T24726; T24726.
DR RefSeq; NP_001022327.2; NM_001027156.4.
DR RefSeq; NP_001022328.2; NM_001027157.2. [P45961-2]
DR AlphaFoldDB; P45961; -.
DR SMR; P45961; -.
DR STRING; 6239.T09A5.1a; -.
DR PaxDb; P45961; -.
DR PRIDE; P45961; -.
DR EnsemblMetazoa; T09A5.1a.1; T09A5.1a.1; WBGene00023408. [P45961-1]
DR EnsemblMetazoa; T09A5.1b.1; T09A5.1b.1; WBGene00023408. [P45961-2]
DR GeneID; 188309; -.
DR UCSC; T09A5.1a; c. elegans. [P45961-1]
DR CTD; 188309; -.
DR WormBase; T09A5.1a; CE41840; WBGene00023408; cex-2. [P45961-1]
DR WormBase; T09A5.1b; CE41841; WBGene00023408; cex-2. [P45961-2]
DR eggNOG; ENOG502RYZK; Eukaryota.
DR HOGENOM; CLU_096804_2_0_1; -.
DR InParanoid; P45961; -.
DR OMA; ESKWKHA; -.
DR OrthoDB; 1271932at2759; -.
DR PhylomeDB; P45961; -.
DR PRO; PR:P45961; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00023408; Expressed in larva and 2 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..189
FT /note="Calexcitin-2"
FT /id="PRO_0000073842"
FT DOMAIN 11..47
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 102..137
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 25
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 27
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 29
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 36
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 115
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 117
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 119
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 126
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VAR_SEQ 151..159
FT /note="NHQGQLINS -> VSISEIEKY (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_032764"
FT VAR_SEQ 160..189
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_032765"
SQ SEQUENCE 189 AA; 22240 MW; 38754B031AB701B8 CRC64;
MHPKAANPKE FLESKWKHAF TTFFDLDQNG LIEWKDFKDL IEVIGEVRGR RSDFFMTARL
CLPDIWQKMT EAIGKEEEDI ITLSDWIQLC QSSRKSVREP AWQKAYVEYM FKLLDESGDH
LVDQAEYVQV LGYFGVNRKD SSHCFDQFAF NHQGQLINSI DKKKFHVLWK QFFHSEDPSS
PGNWLLGKV
