CF015_HUMAN
ID CF015_HUMAN Reviewed; 325 AA.
AC Q6UXA7; B0S7V8; Q0EFA6; Q2L6G7; Q5SQ81; Q86Z05; Q9UIG3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 3.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Uncharacterized protein C6orf15;
DE AltName: Full=Protein STG;
DE Flags: Precursor;
GN Name=C6orf15; Synonyms=STG; ORFNames=UNQ1840/PRO3566;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLU-165.
RC TISSUE=Keratinocyte;
RX PubMed=10545595; DOI=10.1093/hmg/8.12.2165;
RA Oka A., Tamiya G., Tomizawa M., Ota M., Katsuyama Y., Makino S., Shiina T.,
RA Yoshitome M., Lizuka M., Sasao Y., Iwashita K., Kawakubo Y., Sugai J.,
RA Ozawa A., Ohkido M., Kimura M., Bahram S., Inoko H.;
RT "Association analysis using refined microsatellite markers localizes a
RT susceptibility locus for psoriasis vulgaris within a 111kb segment
RT telomeric to the HLA-C gene.";
RL Hum. Mol. Genet. 8:2165-2170(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PHE-40; PRO-83 AND
RP GLU-165.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-5.
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS PHE-40; ASP-43;
RP PRO-83 AND GLU-165.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP TISSUE SPECIFICITY, AND VARIANTS PRO-83 AND GLU-165.
RX PubMed=15217361; DOI=10.1111/j.0906-6705.2004.00170.x;
RA Sanchez F., Holm S.J., Mallbris L., O'Brien K.P., Staehle M.;
RT "STG does not associate with psoriasis in the Swedish population.";
RL Exp. Dermatol. 13:413-418(2004).
CC -!- SUBUNIT: Binds to numerous extracellular matrix proteins.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q6UXA7; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11990870, EBI-11962084;
CC Q6UXA7; O75360: PROP1; NbExp=3; IntAct=EBI-11990870, EBI-9027467;
CC Q6UXA7; Q9UHD9: UBQLN2; NbExp=8; IntAct=EBI-11990870, EBI-947187;
CC Q6UXA7; O95231: VENTX; NbExp=3; IntAct=EBI-11990870, EBI-10191303;
CC Q6UXA7; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-11990870, EBI-1051237;
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in skin and tonsils.
CC {ECO:0000269|PubMed:15217361}.
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DR EMBL; AB031481; BAA88132.1; -; mRNA.
DR EMBL; AY358438; AAQ88804.1; -; mRNA.
DR EMBL; AB088114; BAC54947.1; -; Genomic_DNA.
DR EMBL; AB202103; BAE78624.1; -; Genomic_DNA.
DR EMBL; AB103620; BAF31282.1; -; Genomic_DNA.
DR EMBL; AL662867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL773544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03356.1; -; Genomic_DNA.
DR CCDS; CCDS4693.1; -.
DR RefSeq; NP_054789.2; NM_014070.2.
DR AlphaFoldDB; Q6UXA7; -.
DR BioGRID; 118879; 25.
DR IntAct; Q6UXA7; 5.
DR STRING; 9606.ENSP00000259870; -.
DR BioMuta; C6orf15; -.
DR DMDM; 148887353; -.
DR MassIVE; Q6UXA7; -.
DR PaxDb; Q6UXA7; -.
DR PeptideAtlas; Q6UXA7; -.
DR PRIDE; Q6UXA7; -.
DR ProteomicsDB; 67579; -.
DR Antibodypedia; 653; 17 antibodies from 12 providers.
DR DNASU; 29113; -.
DR Ensembl; ENST00000259870.4; ENSP00000259870.3; ENSG00000204542.3.
DR Ensembl; ENST00000383532.4; ENSP00000373024.4; ENSG00000206461.4.
DR Ensembl; ENST00000412706.2; ENSP00000394931.2; ENSG00000231624.2.
DR Ensembl; ENST00000427005.2; ENSP00000398496.2; ENSG00000225543.2.
DR Ensembl; ENST00000440933.2; ENSP00000391756.2; ENSG00000224105.2.
DR Ensembl; ENST00000452899.2; ENSP00000399436.2; ENSG00000229432.2.
DR GeneID; 29113; -.
DR KEGG; hsa:29113; -.
DR MANE-Select; ENST00000259870.4; ENSP00000259870.3; NM_014070.3; NP_054789.2.
DR UCSC; uc003nsk.2; human.
DR CTD; 29113; -.
DR DisGeNET; 29113; -.
DR GeneCards; C6orf15; -.
DR HGNC; HGNC:13927; C6orf15.
DR HPA; ENSG00000204542; Group enriched (cervix, lymphoid tissue, skin).
DR MIM; 611401; gene.
DR neXtProt; NX_Q6UXA7; -.
DR OpenTargets; ENSG00000204542; -.
DR PharmGKB; PA134866404; -.
DR VEuPathDB; HostDB:ENSG00000204542; -.
DR eggNOG; ENOG502SDN4; Eukaryota.
DR GeneTree; ENSGT00390000010291; -.
DR HOGENOM; CLU_919928_0_0_1; -.
DR InParanoid; Q6UXA7; -.
DR OMA; DPWQMMA; -.
DR OrthoDB; 1401291at2759; -.
DR PhylomeDB; Q6UXA7; -.
DR TreeFam; TF338298; -.
DR PathwayCommons; Q6UXA7; -.
DR SignaLink; Q6UXA7; -.
DR BioGRID-ORCS; 29113; 40 hits in 1063 CRISPR screens.
DR GenomeRNAi; 29113; -.
DR Pharos; Q6UXA7; Tdark.
DR PRO; PR:Q6UXA7; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q6UXA7; protein.
DR Bgee; ENSG00000204542; Expressed in skin of leg and 22 other tissues.
DR ExpressionAtlas; Q6UXA7; baseline and differential.
DR Genevisible; Q6UXA7; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR InterPro; IPR026135; C6orf15.
DR PANTHER; PTHR15817; PTHR15817; 1.
DR Pfam; PF15809; STG; 1.
PE 1: Evidence at protein level;
KW Extracellular matrix; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..325
FT /note="Uncharacterized protein C6orf15"
FT /id="PRO_0000019541"
FT REGION 41..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 5
FT /note="V -> M (in dbSNP:rs2270191)"
FT /evidence="ECO:0000269|PubMed:16702430"
FT /id="VAR_054399"
FT VARIANT 40
FT /note="L -> F (in dbSNP:rs2233974)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_022907"
FT VARIANT 43
FT /note="N -> D (in dbSNP:rs2233975)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_022908"
FT VARIANT 48
FT /note="G -> R (in dbSNP:rs2233976)"
FT /id="VAR_050801"
FT VARIANT 81
FT /note="V -> A (in dbSNP:rs2233977)"
FT /id="VAR_028732"
FT VARIANT 83
FT /note="A -> P (in dbSNP:rs1265053)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:15217361"
FT /id="VAR_022909"
FT VARIANT 145
FT /note="A -> P (in dbSNP:rs2233978)"
FT /id="VAR_028733"
FT VARIANT 165
FT /note="K -> E (in dbSNP:rs1265054)"
FT /evidence="ECO:0000269|PubMed:10545595,
FT ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:15217361"
FT /id="VAR_022910"
FT VARIANT 232
FT /note="M -> I (in dbSNP:rs2233982)"
FT /id="VAR_050802"
FT VARIANT 291
FT /note="G -> D (in dbSNP:rs2233984)"
FT /id="VAR_028734"
SQ SEQUENCE 325 AA; 34195 MW; 8ED611FD4F9364E3 CRC64;
MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP SSTGPSNSEH
PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP SWGLPAMDSW PPEDPWQMMA
AAAEDRLGEA LPEELSYLSS AAALAPGSGP LPGESSPDAT GLSPKASLLH QDSESRRLPR
SNSLGAGGKI LSQRPPWSLI HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG
INNQPPGTSW GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV
LRPPGSSWNI PAGFPNPPSP RLQWG
