CF015_MOUSE
ID CF015_MOUSE Reviewed; 349 AA.
AC Q8BM15; Q3KNI3; Q3KNI4;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Uncharacterized protein C6orf15 homolog;
DE AltName: Full=Extracellular matrix protein with prion homology;
DE Short=Emprin;
DE AltName: Full=Protein STG;
DE Flags: Precursor;
GN Name=Stg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, SUBUNIT, AND DEVELOPMENTAL STAGE.
RX PubMed=18757743; DOI=10.1073/pnas.0803640105;
RA Manabe R., Tsutsui K., Yamada T., Kimura M., Nakano I., Shimono C.,
RA Sanzen N., Furutani Y., Fukuda T., Oguri Y., Shimamoto K., Kiyozumi D.,
RA Sato Y., Sado Y., Senoo H., Yamashina S., Fukuda S., Kawai J., Sugiura N.,
RA Kimata K., Hayashizaki Y., Sekiguchi K.;
RT "Transcriptome-based systematic identification of extracellular matrix
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:12849-12854(2008).
CC -!- SUBUNIT: Binds to numerous extracellular matrix proteins.
CC {ECO:0000269|PubMed:18757743}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000269|PubMed:18757743}.
CC -!- DEVELOPMENTAL STAGE: At 16.5 dpc, present in rib cartilage (at protein
CC level). {ECO:0000269|PubMed:18757743}.
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DR EMBL; AK037046; BAC29684.1; -; mRNA.
DR EMBL; BC107265; AAI07266.1; -; mRNA.
DR EMBL; BC107266; AAI07267.1; -; mRNA.
DR CCDS; CCDS50092.1; -.
DR RefSeq; NP_780357.1; NM_175148.3.
DR AlphaFoldDB; Q8BM15; -.
DR STRING; 10090.ENSMUSP00000038043; -.
DR PaxDb; Q8BM15; -.
DR PRIDE; Q8BM15; -.
DR ProteomicsDB; 281387; -.
DR Antibodypedia; 653; 17 antibodies from 12 providers.
DR DNASU; 69542; -.
DR Ensembl; ENSMUST00000044326; ENSMUSP00000038043; ENSMUSG00000039269.
DR GeneID; 69542; -.
DR KEGG; mmu:69542; -.
DR UCSC; uc008cib.1; mouse.
DR MGI; MGI:1916792; 2300002M23Rik.
DR VEuPathDB; HostDB:ENSMUSG00000039269; -.
DR eggNOG; ENOG502SDN4; Eukaryota.
DR GeneTree; ENSGT00390000010291; -.
DR HOGENOM; CLU_919928_0_0_1; -.
DR InParanoid; Q8BM15; -.
DR OMA; DPWQMMA; -.
DR OrthoDB; 1401291at2759; -.
DR PhylomeDB; Q8BM15; -.
DR TreeFam; TF338298; -.
DR BioGRID-ORCS; 69542; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8BM15; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8BM15; protein.
DR Bgee; ENSMUSG00000039269; Expressed in esophagus and 34 other tissues.
DR Genevisible; Q8BM15; MM.
DR GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IDA:MGI.
DR GO; GO:0005518; F:collagen binding; IDA:MGI.
DR GO; GO:0070052; F:collagen V binding; IDA:MGI.
DR GO; GO:0001968; F:fibronectin binding; IDA:MGI.
DR GO; GO:0005539; F:glycosaminoglycan binding; IDA:MGI.
DR GO; GO:0008201; F:heparin binding; IDA:MGI.
DR GO; GO:0005540; F:hyaluronic acid binding; IDA:MGI.
DR GO; GO:0043236; F:laminin binding; IDA:MGI.
DR GO; GO:0030198; P:extracellular matrix organization; IDA:MGI.
DR InterPro; IPR026135; C6orf15.
DR PANTHER; PTHR15817; PTHR15817; 1.
DR Pfam; PF15809; STG; 1.
PE 1: Evidence at protein level;
KW Extracellular matrix; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..349
FT /note="Uncharacterized protein C6orf15 homolog"
FT /id="PRO_0000363883"
FT REGION 30..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 144
FT /note="R -> W (in Ref. 2; AAI07267)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="L -> P (in Ref. 2; AAI07267)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="T -> P (in Ref. 2; AAI07267)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 349 AA; 36654 MW; 4EE56EC6197B254F CRC64;
MQSHAGGSRA PLGLLLICLC LPGLFARSTG APEEKASPHS GQPSFTSLLN PGQPQPKPDP
VNNELLGVLP RLSESPQDGA LPEGGSEVPN GPPFWGPPPM ESWPSEDPQQ GMAAVAEDQL
EQMLPEALPY LSRGGRLPEA SSARLRQPSL AASYPQDSEA GLQPGSSSLE TEAEAFARSP
FWFLIHKLLP GSSGRILRPG TSWGSGGAGT GWGTRPMPYP SGIWGSNGLV SGTSLGGRGP
YPVRIWGRNG WYPLRILGGN GRYPPVGTWG GYGQYPPVGT WGGYGQYPPV GPWGGYGQYP
PVGTWGANCQ YPAGSRRPNC RYPAGSWGTK GQNRLPPGAK RPGSSGITP
