CF052_HUMAN
ID CF052_HUMAN Reviewed; 152 AA.
AC Q5T4I8; Q5T4I7; Q96AS6;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Putative uncharacterized protein C6orf52;
GN Name=C6orf52;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Bone marrow;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T4I8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T4I8-2; Sequence=VSP_026991;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16820.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL358777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016820; AAH16820.1; ALT_INIT; mRNA.
DR CCDS; CCDS47371.1; -. [Q5T4I8-1]
DR RefSeq; NP_001138492.1; NM_001145020.1. [Q5T4I8-1]
DR AlphaFoldDB; Q5T4I8; -.
DR STRING; 9606.ENSP00000259983; -.
DR BioMuta; C6orf52; -.
DR DMDM; 158563914; -.
DR PaxDb; Q5T4I8; -.
DR PeptideAtlas; Q5T4I8; -.
DR PRIDE; Q5T4I8; -.
DR Antibodypedia; 63185; 37 antibodies from 7 providers.
DR DNASU; 347744; -.
DR Ensembl; ENST00000259983.8; ENSP00000259983.3; ENSG00000137434.12. [Q5T4I8-1]
DR Ensembl; ENST00000379586.5; ENSP00000368905.1; ENSG00000137434.12. [Q5T4I8-2]
DR Ensembl; ENST00000426700.6; ENSP00000410749.2; ENSG00000137434.12. [Q5T4I8-1]
DR Ensembl; ENST00000642282.1; ENSP00000494707.1; ENSG00000285312.1. [Q5T4I8-1]
DR Ensembl; ENST00000644703.1; ENSP00000495171.1; ENSG00000285312.1. [Q5T4I8-1]
DR Ensembl; ENST00000647114.1; ENSP00000493951.1; ENSG00000285312.1. [Q5T4I8-2]
DR GeneID; 347744; -.
DR KEGG; hsa:347744; -.
DR MANE-Select; ENST00000259983.8; ENSP00000259983.3; NM_001145020.3; NP_001138492.1.
DR UCSC; uc011dij.3; human. [Q5T4I8-1]
DR CTD; 347744; -.
DR GeneCards; C6orf52; -.
DR HGNC; HGNC:20881; C6orf52.
DR HPA; ENSG00000137434; Tissue enhanced (testis).
DR neXtProt; NX_Q5T4I8; -.
DR OpenTargets; ENSG00000137434; -.
DR PharmGKB; PA134991266; -.
DR VEuPathDB; HostDB:ENSG00000137434; -.
DR eggNOG; ENOG502TEG3; Eukaryota.
DR GeneTree; ENSGT00940000163315; -.
DR HOGENOM; CLU_144889_0_0_1; -.
DR InParanoid; Q5T4I8; -.
DR OMA; DSLMSCH; -.
DR OrthoDB; 1170177at2759; -.
DR PhylomeDB; Q5T4I8; -.
DR TreeFam; TF341075; -.
DR PathwayCommons; Q5T4I8; -.
DR BioGRID-ORCS; 347744; 14 hits in 1045 CRISPR screens.
DR GenomeRNAi; 347744; -.
DR Pharos; Q5T4I8; Tdark.
DR PRO; PR:Q5T4I8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5T4I8; protein.
DR Bgee; ENSG00000137434; Expressed in right testis and 94 other tissues.
DR ExpressionAtlas; Q5T4I8; baseline and differential.
DR Genevisible; Q5T4I8; HS.
DR InterPro; IPR040434; TSAP1.
DR InterPro; IPR041085; TSAP1_C.
DR PANTHER; PTHR37457; PTHR37457; 1.
DR Pfam; PF17654; Trnau1ap; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..152
FT /note="Putative uncharacterized protein C6orf52"
FT /id="PRO_0000295687"
FT VAR_SEQ 1..87
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026991"
FT VARIANT 13
FT /note="A -> D (in dbSNP:rs7749306)"
FT /id="VAR_033318"
SQ SEQUENCE 152 AA; 17383 MW; 0B14EAF0C01E25CD CRC64;
MAQPESSADF GIAQQNNYYC YWQSLPSAIR VKQEFQPSQS YRYGNWYARQ HGSYLLSGYS
YGCAVDGNGK DCFSAHETPE HTAGTLVMPK ETTPLAENQD EDPLEDPHLH LNIEESNQEF
MVKSEELYDS LMNCHWQPLD TVHSEIPDET PK
