CF089_MOUSE
ID CF089_MOUSE Reviewed; 348 AA.
AC Q99KU6; Q6PDQ4; Q7TSE2; Q7TSE4; Q8BST4;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Bombesin receptor-activated protein C6orf89 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-348.
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Exhibits histone deacetylase (HDAC) enhancer properties. May
CC play a role in cell cycle progression and wound repair of bronchial
CC epithelial cells. {ECO:0000250|UniProtKB:Q6UWU4}.
CC -!- SUBUNIT: Homodimer (By similarity). Interacts with BRS3. Interacts (via
CC N-terminus) with SIN3B. {ECO:0000250|UniProtKB:Q6UWU4}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q6UWU4}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:Q6UWU4}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q6UWU4}.
CC -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q6UWU4}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP45201.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY301264; AAP45198.1; -; Genomic_DNA.
DR EMBL; AY301264; AAP45201.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC004004; AAH04004.1; -; mRNA.
DR EMBL; BC058575; AAH58575.1; -; mRNA.
DR EMBL; AK030596; BAC27038.1; -; mRNA.
DR CCDS; CCDS28594.1; -.
DR RefSeq; NP_085038.3; NM_030561.3.
DR RefSeq; XP_006525237.1; XM_006525174.3.
DR AlphaFoldDB; Q99KU6; -.
DR SMR; Q99KU6; -.
DR STRING; 10090.ENSMUSP00000066224; -.
DR iPTMnet; Q99KU6; -.
DR PhosphoSitePlus; Q99KU6; -.
DR EPD; Q99KU6; -.
DR MaxQB; Q99KU6; -.
DR PaxDb; Q99KU6; -.
DR PRIDE; Q99KU6; -.
DR Antibodypedia; 2729; 37 antibodies from 11 providers.
DR Ensembl; ENSMUST00000064709; ENSMUSP00000066224; ENSMUSG00000052712.
DR Ensembl; ENSMUST00000149405; ENSMUSP00000117309; ENSMUSG00000052712.
DR Ensembl; ENSMUST00000234256; ENSMUSP00000157363; ENSMUSG00000052712.
DR Ensembl; ENSMUST00000234711; ENSMUSP00000157208; ENSMUSG00000052712.
DR Ensembl; ENSMUST00000234773; ENSMUSP00000157182; ENSMUSG00000052712.
DR Ensembl; ENSMUST00000235023; ENSMUSP00000157274; ENSMUSG00000052712.
DR GeneID; 80748; -.
DR KEGG; mmu:80748; -.
DR UCSC; uc008bsn.2; mouse.
DR MGI; MGI:2136782; BC004004.
DR VEuPathDB; HostDB:ENSMUSG00000052712; -.
DR eggNOG; ENOG502S363; Eukaryota.
DR GeneTree; ENSGT00390000014270; -.
DR HOGENOM; CLU_796829_0_0_1; -.
DR InParanoid; Q99KU6; -.
DR OMA; HCEMFKV; -.
DR OrthoDB; 1010604at2759; -.
DR PhylomeDB; Q99KU6; -.
DR TreeFam; TF335525; -.
DR BioGRID-ORCS; 80748; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q99KU6; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q99KU6; protein.
DR Bgee; ENSMUSG00000052712; Expressed in pigmented layer of retina and 251 other tissues.
DR ExpressionAtlas; Q99KU6; baseline and differential.
DR Genevisible; Q99KU6; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0050673; P:epithelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:1901727; P:positive regulation of histone deacetylase activity; ISS:UniProtKB.
DR GO; GO:0042060; P:wound healing; ISS:UniProtKB.
DR InterPro; IPR038757; BRAP.
DR PANTHER; PTHR35259; PTHR35259; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..348
FT /note="Bombesin receptor-activated protein C6orf89 homolog"
FT /id="PRO_0000237622"
FT TOPO_DOM 1..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..348
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT CONFLICT 190
FT /note="P -> S (in Ref. 2; AAH58575)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="S -> G (in Ref. 2; AAP45198)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="D -> E (in Ref. 2; AAP45198)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 348 AA; 39486 MW; 4DC5F56EACB84759 CRC64;
MDLAANEISI YDKLSETVDL VRQTGHQCGM SEKAIEKFIR QLLEKNEPQR GPPQYPLLIA
VYKVLLTLGL ILFTAYFVIQ PFSSLAPEPV LSGANSWRSL VHHIRLVSLP ITKKYMPENK
GVPLQGSQED KPFPDFDPWS SYNCEQNESE PIPANCTGCA QILPLKVTLP EDTPKNFERL
RPLVIKTGQP LSSAEIQSFS CQYPEVTEGF TEGFFTKWWR CFPERWFPFP YPWRRPLNRS
QILRELFPVF TQLPFPKDSS LNKCFLIQPE PVVGSKMHKV HDLFTLGSGE AMLQLIPPFQ
CRTHCQSVAM PIESGDIGYA DAAHWKVYIV ARGVQPLVIC DGTTLSDL
