ID   CF089_RAT               Reviewed;         348 AA.
AC   Q6P6G2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Bombesin receptor-activated protein C6orf89 homolog;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Exhibits histone deacetylase (HDAC) enhancer properties. May
CC       play a role in cell cycle progression and wound repair of bronchial
CC       epithelial cells. {ECO:0000250|UniProtKB:Q6UWU4}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with BRS3 (By
CC       similarity). Interacts (via N-terminus) with SIN3B (By similarity).
CC       {ECO:0000250|UniProtKB:Q6UWU4}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q6UWU4}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q6UWU4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q6UWU4}.
CC   -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q6UWU4}.
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DR   EMBL; BC062242; AAH62242.1; -; mRNA.
DR   RefSeq; NP_955411.1; NM_199379.2.
DR   AlphaFoldDB; Q6P6G2; -.
DR   SMR; Q6P6G2; -.
DR   STRING; 10116.ENSRNOP00000000631; -.
DR   PaxDb; Q6P6G2; -.
DR   PRIDE; Q6P6G2; -.
DR   GeneID; 294311; -.
DR   KEGG; rno:294311; -.
DR   UCSC; RGD:735065; rat.
DR   CTD; 294311; -.
DR   RGD; 735065; RGD735065.
DR   VEuPathDB; HostDB:ENSRNOG00000000524; -.
DR   eggNOG; ENOG502S363; Eukaryota.
DR   InParanoid; Q6P6G2; -.
DR   OrthoDB; 1010604at2759; -.
DR   PhylomeDB; Q6P6G2; -.
DR   TreeFam; TF335525; -.
DR   PRO; PR:Q6P6G2; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000524; Expressed in liver and 20 other tissues.
DR   ExpressionAtlas; Q6P6G2; baseline and differential.
DR   Genevisible; Q6P6G2; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0050673; P:epithelial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:1901727; P:positive regulation of histone deacetylase activity; ISS:UniProtKB.
DR   GO; GO:0042060; P:wound healing; ISS:UniProtKB.
DR   InterPro; IPR038757; BRAP.
DR   PANTHER; PTHR35259; PTHR35259; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..348
FT                   /note="Bombesin receptor-activated protein C6orf89 homolog"
FT                   /id="PRO_0000237624"
FT   TOPO_DOM        1..58
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..348
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   348 AA;  39572 MW;  0D4C0F548FC5AB4C CRC64;
     MDLAANEISI YDKLSETVDL VRQTGHQCGM SEKAIEKFIR QLLEKNEPQR GPPQYPLLIA
     MYKVLLTLGL ILFTAYFVIQ PFSSLAPEPV LSGAHTWRSL IHHIRLVSLP ITKKYMPENK
     GVPLQGREED KPFPDFDPWS SNNCEQNESE PIPANCTVCA QILPLKVTLP EDTPKNFERL
     RPLVIKTGQP LLSAEIQSFS CQYPEVTEGF TEGVLTKWWR CFPERWFPFP YPWRRPLNRS
     QILRELFPVF TQLPFPKDAS LNKCFLIQPE PVVGSKMHEV HDLFTIGSGE AMLQLIPPFQ
     CRRHCQSVAM PIESGDIGYA GAAHWKVYIV ARGVQPLVIC DGTTLSEL