CF0_SOLLC
ID CF0_SOLLC Reviewed; 845 AA.
AC O49879; K4ASM1;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Receptor-like protein Cf-9 homolog {ECO:0000305};
DE Flags: Precursor;
GN Name=HCR9-0 {ECO:0000312|EMBL:CAA05279.1};
GN Synonyms=CF-0 {ECO:0000303|PubMed:26912238, ECO:0000303|PubMed:9413991};
GN OrderedLocusNames=Solyc01g006550.2.1 {ECO:0000305};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=cv. Moneymaker;
RX PubMed=9413991; DOI=10.1016/s0092-8674(00)80470-5;
RA Parniske M., Hammond-Kosack K.E., Golstein C., Thomas C.M., Jones D.A.,
RA Harrison K., Wulff B.B., Jones J.D.;
RT "Novel disease resistance specificities result from sequence exchange
RT between tandemly repeated genes at the Cf-4/9 locus of tomato.";
RL Cell 91:821-832(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Moneymaker;
RX PubMed=26912238; DOI=10.1186/s12870-016-0737-0;
RA Zhao T., Jiang J., Liu G., He S., Zhang H., Chen X., Li J., Xu X.;
RT "Mapping and candidate gene screening of tomato Cladosporium fulvum-
RT resistant gene Cf-19, based on high-throughput sequencing technology.";
RL BMC Plant Biol. 16:51-51(2016).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706;
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [4]
RP REGULATION BY SLY-MIR6023.
RX PubMed=22307647; DOI=10.1073/pnas.1118282109;
RA Li F., Pignatta D., Bendix C., Brunkard J.O., Cohn M.M., Tung J., Sun H.,
RA Kumar P., Baker B.;
RT "MicroRNA regulation of plant innate immune receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:1790-1795(2012).
CC -!- FUNCTION: At the opposite of its homolog Cf-9 found in
CC S.pimpinellifolium, was not able to confer resistance to the fungal
CC pathogen C.fulvum. {ECO:0000269|PubMed:9413991}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: Repressed by sly-miR6023. {ECO:0000269|PubMed:22307647}.
CC -!- DOMAIN: The extracellular leucine-rich repeats are required for the
CC specificity of the elicitor protein recognition.
CC {ECO:0000250|UniProtKB:Q40235}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
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DR EMBL; AJ002237; CAA05279.1; -; Genomic_DNA.
DR EMBL; KT874513; AMN14931.1; -; Genomic_DNA.
DR EMBL; CM001064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; T07039; T07039.
DR RefSeq; XP_004228623.1; XM_004228575.3.
DR RefSeq; XP_019069253.1; XM_019213708.1.
DR AlphaFoldDB; O49879; -.
DR SMR; O49879; -.
DR STRING; 4081.Solyc01g006550.2.1; -.
DR PRIDE; O49879; -.
DR GeneID; 101247650; -.
DR KEGG; sly:101247650; -.
DR eggNOG; KOG0619; Eukaryota.
DR OrthoDB; 826997at2759; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; O49879; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 8.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..845
FT /note="Receptor-like protein Cf-9 homolog"
FT /id="PRO_0000442981"
FT TOPO_DOM 20..794
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 795..815
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 816..845
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 71..94
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000305"
FT REPEAT 95..118
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 119..143
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 144..171
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 172..193
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 194..217
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 219..242
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 244..266
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 267..291
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 292..316
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 318..338
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 340..364
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 365..388
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 390..410
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 411..434
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 436..458
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 459..482
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 484..506
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 507..531
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 532..554
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 555..579
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 581..605
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 649..672
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 673..696
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 698..721
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT REPEAT 723..741
FT /note="LRR 26"
FT /evidence="ECO:0000255"
FT REGION 20..70
FT /note="N-cap"
FT /evidence="ECO:0000250|UniProtKB:Q40235"
FT REGION 742..794
FT /note="C-cap/acidic domain"
FT /evidence="ECO:0000250|UniProtKB:Q40235"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 360
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 398
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 446
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 501
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 545
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 656
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 680
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 696
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 728
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 749
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 11
FT /note="L -> P (in Ref. 1; CAA05279 and 2; AMN14931)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 845 AA; 95384 MW; A72CDEB775490DE4 CRC64;
MGCVKLVFFM LLKLDLLEFK NMFTVNPNAS DYCYDYTDQR MQSYPRTLFW NKSTDCCSWD
GIHCDETTGQ VVELDLRCSQ LQGKFHSNSS LFQLSNLKRL DLSFNDFTGS LISPKFGEFS
DLTHLDLSDS NFTGVIPSEI SHLSKLHVLR IHDLNELSLG PHNFELLLKN LTQLRELNLD
SVNISSTIPS NFSSHLTNLW LPYTELRGVL PERVFHLSDL EFLHLSYNPQ LTVRFPTTKW
NSSASLMKLY VHSVNIADRI PESFSHLTSL HALYMGRCNL SGHIPKPLWN LTNIESLFLG
DNHLEGPIPQ LTRFEKLKRL SLGNNNLHGG LEFLSFNRSW TQLEILYFSS NYLTGPIPSN
VSGLQNLGWL FLSSNHLNGS IPSWIFSLPS LVVLDLSNNT FSGKIQEFKS KTLSTVTLKQ
NQLEGPIPNS LLNQESLQFL LLSHNNISGY ISSSICNLKT LMVLDLGSNN LEGTIPQCVG
ERNEYLLDLD LSNNRLSGTI NTTFSIGNSF KAISLHGNKL TGKVPRSLIN CKYLKLLDLG
NNQLNDTFPN WLGYLSQLKI LSLRSNKLHG PIKSSGSTNL FMRLQILDLS SNGFSGNLPE
RILGNLQTMK KIDENTRFPE YISDQYEIYY VYLTTITTKG QDYDSVRILD SNMIINLSKN
RFEGHIPSII GDLVGLRTLN LSRNALEGHI PASFQNLSVL ESLDLSSNRI SGEIPQQLAS
LTFLEVLNLS HNHLVGCIPK GKQFDSFGNT SYQGNDGLRG FPLSKLCGVD DQVTTPAELD
QEEEEEDSPM ISWQGVLVGY GCGLVIGLSV IYIMWSTQYP AWFSRMDLKL EHIITTRMKK
HKKRY
