CF107_MOUSE
ID CF107_MOUSE Reviewed; 196 AA.
AC Q4KKZ1; A2A7Z7; Q08EE4; Q9DAD4;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Cilia- and flagella-associated protein 107 {ECO:0000250|UniProtKB:Q8N1D5};
GN Name=Cfap107 {ECO:0000250|UniProtKB:Q8N1D5};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000250|UniProtKB:Q2TA11}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q2TA11}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH99569.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI16373.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI26972.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK005933; BAB24324.1; -; mRNA.
DR EMBL; AL607073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466657; EDL29713.1; -; Genomic_DNA.
DR EMBL; BC099569; AAH99569.1; ALT_INIT; mRNA.
DR EMBL; BC116372; AAI16373.1; ALT_INIT; mRNA.
DR EMBL; BC126971; AAI26972.1; ALT_INIT; mRNA.
DR CCDS; CCDS51365.1; -.
DR RefSeq; NP_081332.1; NM_027056.1.
DR AlphaFoldDB; Q4KKZ1; -.
DR SMR; Q4KKZ1; -.
DR STRING; 10090.ENSMUSP00000030323; -.
DR PhosphoSitePlus; Q4KKZ1; -.
DR PaxDb; Q4KKZ1; -.
DR PRIDE; Q4KKZ1; -.
DR Antibodypedia; 28545; 48 antibodies from 12 providers.
DR Ensembl; ENSMUST00000030323; ENSMUSP00000030323; ENSMUSG00000028589.
DR GeneID; 69364; -.
DR KEGG; mmu:69364; -.
DR UCSC; uc008vrf.1; mouse.
DR CTD; 93190; -.
DR MGI; MGI:1916614; 1700012P22Rik.
DR VEuPathDB; HostDB:ENSMUSG00000028589; -.
DR eggNOG; ENOG502RZRC; Eukaryota.
DR GeneTree; ENSGT00390000014553; -.
DR HOGENOM; CLU_100733_1_0_1; -.
DR InParanoid; Q4KKZ1; -.
DR OMA; EKTPQCI; -.
DR OrthoDB; 1255878at2759; -.
DR PhylomeDB; Q4KKZ1; -.
DR TreeFam; TF328903; -.
DR BioGRID-ORCS; 69364; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q4KKZ1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q4KKZ1; protein.
DR Bgee; ENSMUSG00000028589; Expressed in seminiferous tubule of testis and 17 other tissues.
DR Genevisible; Q4KKZ1; MM.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR InterPro; IPR037662; CFAP107.
DR PANTHER; PTHR31180; PTHR31180; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..196
FT /note="Cilia- and flagella-associated protein 107"
FT /id="PRO_0000247261"
SQ SEQUENCE 196 AA; 23026 MW; E02CD2BC8A1FBDDB CRC64;
MAMLSTSVVP EAFSTPGWQI EKKYSTKVLL GNWVEERGKF TKAIDHTPQC IYRKEYVPMP
DHRPDFVSRW YSKSKMEGLP YKHLITHHQE PSHRYLISTY DDHYNRHNYN PGLPALRTWN
GQKLLWLPEK SDFPLVAPPT NYGLLEQLQQ KWLASKTSLK ESIYTTSYPR LPVCAMSRRE
HAIPVPHPRL QPIPRF
