ID   CF118_HUMAN             Reviewed;         469 AA.
AC   Q5T5N4; Q8TC11;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Uncharacterized protein C6orf118;
GN   Name=C6orf118;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLU-271 AND GLN-385.
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AL356125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL117345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC026278; AAH26278.1; -; mRNA.
DR   CCDS; CCDS5288.1; -.
DR   RefSeq; NP_659417.2; NM_144980.3.
DR   AlphaFoldDB; Q5T5N4; -.
DR   SMR; Q5T5N4; -.
DR   BioGRID; 127954; 10.
DR   IntAct; Q5T5N4; 4.
DR   STRING; 9606.ENSP00000230301; -.
DR   iPTMnet; Q5T5N4; -.
DR   PhosphoSitePlus; Q5T5N4; -.
DR   BioMuta; C6orf118; -.
DR   DMDM; 71152375; -.
DR   EPD; Q5T5N4; -.
DR   MassIVE; Q5T5N4; -.
DR   PaxDb; Q5T5N4; -.
DR   PeptideAtlas; Q5T5N4; -.
DR   PRIDE; Q5T5N4; -.
DR   ProteomicsDB; 64534; -.
DR   Antibodypedia; 33511; 18 antibodies from 7 providers.
DR   DNASU; 168090; -.
DR   Ensembl; ENST00000230301.9; ENSP00000230301.8; ENSG00000112539.15.
DR   GeneID; 168090; -.
DR   KEGG; hsa:168090; -.
DR   MANE-Select; ENST00000230301.9; ENSP00000230301.8; NM_144980.4; NP_659417.2.
DR   UCSC; uc003qum.5; human.
DR   CTD; 168090; -.
DR   GeneCards; C6orf118; -.
DR   HGNC; HGNC:21233; C6orf118.
DR   HPA; ENSG00000112539; Group enriched (brain, choroid plexus, fallopian tube, testis).
DR   neXtProt; NX_Q5T5N4; -.
DR   OpenTargets; ENSG00000112539; -.
DR   PharmGKB; PA134954942; -.
DR   VEuPathDB; HostDB:ENSG00000112539; -.
DR   eggNOG; ENOG502RB3J; Eukaryota.
DR   GeneTree; ENSGT00390000009877; -.
DR   HOGENOM; CLU_040125_0_0_1; -.
DR   InParanoid; Q5T5N4; -.
DR   OMA; NADRYRM; -.
DR   OrthoDB; 1005609at2759; -.
DR   PhylomeDB; Q5T5N4; -.
DR   TreeFam; TF329261; -.
DR   PathwayCommons; Q5T5N4; -.
DR   SignaLink; Q5T5N4; -.
DR   BioGRID-ORCS; 168090; 9 hits in 1036 CRISPR screens.
DR   ChiTaRS; C6orf118; human.
DR   GenomeRNAi; 168090; -.
DR   Pharos; Q5T5N4; Tdark.
DR   PRO; PR:Q5T5N4; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5T5N4; protein.
DR   Bgee; ENSG00000112539; Expressed in right uterine tube and 91 other tissues.
DR   Genevisible; Q5T5N4; HS.
DR   InterPro; IPR032755; TSNAXIP1_N.
DR   Pfam; PF15739; TSNAXIP1_N; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..469
FT                   /note="Uncharacterized protein C6orf118"
FT                   /id="PRO_0000089523"
FT   REGION          152..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          346..375
FT                   /evidence="ECO:0000255"
FT   COILED          423..453
FT                   /evidence="ECO:0000255"
FT   VARIANT         166
FT                   /note="R -> L (in dbSNP:rs36007498)"
FT                   /id="VAR_050807"
FT   VARIANT         256
FT                   /note="I -> M (in dbSNP:rs510579)"
FT                   /id="VAR_022887"
FT   VARIANT         271
FT                   /note="G -> E (in dbSNP:rs17852379)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_050808"
FT   VARIANT         301
FT                   /note="T -> M (in dbSNP:rs540751)"
FT                   /id="VAR_050809"
FT   VARIANT         363
FT                   /note="V -> L (in dbSNP:rs9459350)"
FT                   /id="VAR_022888"
FT   VARIANT         385
FT                   /note="R -> Q (in dbSNP:rs17856754)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_050810"
SQ   SEQUENCE   469 AA;  53772 MW;  EE38A4E9C3290040 CRC64;
     MAEEREPELY LKWKHCETPG VKTLCNLKHC ETPGVKTLCN LKKLLNRLQK DHREDVYLYI
     SGHLNPNKLY QPPETILQHW PNAHRPKGER ASEVGEPPAG KVARMKEALA HFTIHTALVP
     SEAQDTPLFR YLNPQASLSH TSEEDFLPVE AVREGKEEKK GGPPGRGPPG WRRREELRLP
     DLKVLCYQEA GSRGTRDRHH YVSSYLAGAT SADRYRMFLR FQKEVLAKQD LLKNDFTGSK
     AAAGHERKLQ QELQKICTCS PQQFNRLHVF GKVFEDICNS SLIFGDLLKK VKDEYELYMA
     TLLESQPAAQ YEALLAQLKA LGQRPVKTAD MDLAREELRM LVTATKAALE QNDRLRSELE
     MEVALLQSAK ERSESSEKHI IDENRLTLTE KVEKKRCEIL SKWDEIQALE KEIKTTLVHT
     GISDITENRI KSIEHEAIQL ETENMILKKK IKGPLEIYQG ICKIRGNRR