CF119_MOUSE
ID CF119_MOUSE Reviewed; 333 AA.
AC Q6NZQ0; Q3UST8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Cilia- and flagella-associated protein 119 {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 189 {ECO:0000312|MGI:MGI:2685012};
GN Name=Cfap119 {ECO:0000250|UniProtKB:A1A4V9};
GN Synonyms=Ccdc189 {ECO:0000312|MGI:MGI:2685012},
GN Gm166 {ECO:0000312|EMBL:AAH66021.2};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:B0BMZ6}. Cytoplasmic vesicle, secretory vesicle,
CC acrosome {ECO:0000250|UniProtKB:B0BMZ6}. Cytoplasm
CC {ECO:0000250|UniProtKB:B0BMZ6}. Note=In elongated spermatids, enriched
CC in the principal piece of flagella where it is peri-axonemal.
CC Disappears from sperm heads upon acrosome reaction.
CC {ECO:0000250|UniProtKB:B0BMZ6}.
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DR EMBL; AK140121; BAE24243.1; -; mRNA.
DR EMBL; BC066021; AAH66021.2; -; mRNA.
DR CCDS; CCDS21870.1; -.
DR RefSeq; NP_001028212.1; NM_001033040.3.
DR AlphaFoldDB; Q6NZQ0; -.
DR SMR; Q6NZQ0; -.
DR STRING; 10090.ENSMUSP00000072019; -.
DR iPTMnet; Q6NZQ0; -.
DR PhosphoSitePlus; Q6NZQ0; -.
DR PaxDb; Q6NZQ0; -.
DR PRIDE; Q6NZQ0; -.
DR ProteomicsDB; 265300; -.
DR Antibodypedia; 66032; 37 antibodies from 12 providers.
DR Ensembl; ENSMUST00000072155; ENSMUSP00000072019; ENSMUSG00000057176.
DR GeneID; 233899; -.
DR KEGG; mmu:233899; -.
DR UCSC; uc009jwd.2; mouse.
DR CTD; 233899; -.
DR MGI; MGI:2685012; Ccdc189.
DR VEuPathDB; HostDB:ENSMUSG00000057176; -.
DR eggNOG; ENOG502RXPT; Eukaryota.
DR GeneTree; ENSGT00940000154323; -.
DR HOGENOM; CLU_073614_0_0_1; -.
DR InParanoid; Q6NZQ0; -.
DR OMA; VEECYHY; -.
DR OrthoDB; 1491476at2759; -.
DR PhylomeDB; Q6NZQ0; -.
DR TreeFam; TF343725; -.
DR BioGRID-ORCS; 233899; 0 hits in 32 CRISPR screens.
DR PRO; PR:Q6NZQ0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6NZQ0; protein.
DR Bgee; ENSMUSG00000057176; Expressed in seminiferous tubule of testis and 119 other tissues.
DR ExpressionAtlas; Q6NZQ0; baseline and differential.
DR Genevisible; Q6NZQ0; MM.
DR GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0097228; C:sperm principal piece; ISS:UniProtKB.
DR InterPro; IPR032727; CLAMP.
DR PANTHER; PTHR28457; PTHR28457; 1.
DR Pfam; PF14769; CLAMP; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoplasmic vesicle;
KW Flagellum; Phosphoprotein; Reference proteome.
FT CHAIN 1..333
FT /note="Cilia- and flagella-associated protein 119"
FT /id="PRO_0000321843"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 284..319
FT /evidence="ECO:0000255"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 333 AA; 37873 MW; F21B484E15CFA352 CRC64;
MITPSSSQSL GMKVQMESEQ SPKLQEELDR SPSSVDGSAI RNGTDMQTES PAEATSSPVE
VAEDPGANLF PPPLPQPRIC MWKYLDIHSM HRLEKAATVE KMREVLAELL ELGFPEQSLR
DAIILDLFSH ALIFCRQQGF SPEQTSAACA MLQDLHKACV ATPLGNVEEC YRYFTSVLFC
HGIRRPPFSI DLFKEEQLLA LADYVVNTYF RHFKLYKYVF TPQVRLDLSL TYTGLQPLTL
WPEEKENEEM MVVEQVATPQ EEEPETVTEP EQQPSEVCIL QTYIKSQLSK ELRQLQQLVE
ERLKESEERL SSKLAALEQP FQTPPSKGKT KTK
