CF119_RAT
ID CF119_RAT Reviewed; 332 AA.
AC B0BMZ6; A0A0H5BIB4; F1LNM9;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Cilia- and flagella-associated protein 119 {ECO:0000305|PubMed:15489334};
DE AltName: Full=Coiled-coil domain-containing protein 189 {ECO:0000312|RGD:1593368};
DE AltName: Full=Spergen-4 {ECO:0000303|PubMed:27032685};
GN Name=Cfap119 {ECO:0000312|RGD:1593368};
GN Synonyms=Ccdc189 {ECO:0000312|RGD:1593368};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=Wistar; TISSUE=Testis;
RX PubMed=27032685; DOI=10.2108/zs150104;
RA Howida A., Salaheldeen E., Iida H.;
RT "Molecular Cloning of Spergen-4, Encoding a Spermatogenic Cell-Specific
RT Protein Associated with Sperm Flagella and the Acrosome Region in Rat
RT Spermatozoa.";
RL Zool. Sci. 33:195-203(2016).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:27032685}. Cytoplasmic vesicle, secretory vesicle,
CC acrosome {ECO:0000269|PubMed:27032685}. Cytoplasm
CC {ECO:0000269|PubMed:27032685}. Note=In elongated spermatids, enriched
CC in the principal piece of flagella where it is peri-axonemal
CC (PubMed:15489334). Disappears from sperm heads upon acrosome reaction
CC (PubMed:15489334). {ECO:0000269|PubMed:15489334}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis (at protein
CC level). {ECO:0000269|PubMed:27032685}.
CC -!- DEVELOPMENTAL STAGE: Expression is detected at 3 weeks of postnatal
CC development and persists up to adulthood (PubMed:27032685). Expressed
CC in elongated spermatids but not detected in spermatogonia,
CC spermatocytes, and round spermatids (PubMed:27032685).
CC {ECO:0000269|PubMed:27032685}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAR94674.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; LC063347; BAR94674.1; ALT_INIT; mRNA.
DR EMBL; AC120262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473956; EDM17260.1; -; Genomic_DNA.
DR EMBL; BC158625; AAI58626.1; -; mRNA.
DR RefSeq; NP_001128166.2; NM_001134694.2.
DR AlphaFoldDB; B0BMZ6; -.
DR SMR; B0BMZ6; -.
DR STRING; 10116.ENSRNOP00000043649; -.
DR PhosphoSitePlus; B0BMZ6; -.
DR PaxDb; B0BMZ6; -.
DR GeneID; 691909; -.
DR KEGG; rno:691909; -.
DR UCSC; RGD:1593368; rat.
DR CTD; 90835; -.
DR RGD; 1593368; Cfap119.
DR VEuPathDB; HostDB:ENSRNOG00000053015; -.
DR eggNOG; ENOG502RXPT; Eukaryota.
DR HOGENOM; CLU_073614_0_0_1; -.
DR InParanoid; B0BMZ6; -.
DR OMA; VEECYHY; -.
DR OrthoDB; 1491476at2759; -.
DR PhylomeDB; B0BMZ6; -.
DR TreeFam; TF343725; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Proteomes; UP000234681; Chromosome 1.
DR Bgee; ENSRNOG00000053015; Expressed in testis and 20 other tissues.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0097228; C:sperm principal piece; IDA:UniProtKB.
DR InterPro; IPR032727; CLAMP.
DR PANTHER; PTHR28457; PTHR28457; 1.
DR Pfam; PF14769; CLAMP; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoplasmic vesicle;
KW Flagellum; Reference proteome.
FT CHAIN 1..332
FT /note="Cilia- and flagella-associated protein 119"
FT /id="PRO_0000454662"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 287..308
FT /evidence="ECO:0000255"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 37860 MW; BCA0E9D859CCA193 CRC64;
MITPRSSQSL EMKVQTELEH SPKLQEEPDR SPSLVDSSVI RIGTDEQNES PAEATSSPVE
VAEDPGANLF PPPLPQPRIC MWKYLDIHSM HRLEKAATVE EMREVLAELL ELGGPEQSLR
DAIILDLFSH ALIFCRQQGF SLEQTSAACA LLQDLHKACV ATPLGNVEEC YRYFTSVLFC
HGVRRPPFSI DLFKEEQLLA LADYVVNTYF RHFKLYKYVF TPQVRLDLSL SYMGLQSLHL
WPEEKEDEEA TVEQAATPQE EEPEAVTEAE QQPSEVCILQ TYIKCQLNKE LRQLQQLVEE
RLKESEERLS NRLAALERPY QTPPSKGKSK AK
