CF120_MOUSE
ID CF120_MOUSE Reviewed; 185 AA.
AC Q9DAY5; Q80ST2; Q8CEI9; Q9CU86;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=UPF0669 protein C6orf120 homolog;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Cerebellum, Head, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in induction of apoptosis in CD4(+) T-cells,
CC but not CD8(+) T-cells or hepatocytes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted by
CC hepatocytes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UPF0669 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH43303.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH43449.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB30667.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC25722.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK005427; BAB24021.1; -; mRNA.
DR EMBL; AK017276; BAB30667.1; ALT_INIT; mRNA.
DR EMBL; AK028052; BAC25722.1; ALT_FRAME; mRNA.
DR EMBL; AK150772; BAE29838.1; -; mRNA.
DR EMBL; AK167490; BAE39568.1; -; mRNA.
DR EMBL; BC043303; AAH43303.1; ALT_INIT; mRNA.
DR EMBL; BC043449; AAH43449.1; ALT_INIT; mRNA.
DR CCDS; CCDS37444.1; -.
DR RefSeq; NP_001077349.1; NM_001083880.1.
DR RefSeq; NP_001077350.1; NM_001083881.1.
DR RefSeq; NP_001077351.1; NM_001083882.1.
DR RefSeq; NP_080727.2; NM_026451.2.
DR AlphaFoldDB; Q9DAY5; -.
DR STRING; 10090.ENSMUSP00000125970; -.
DR GlyGen; Q9DAY5; 1 site.
DR PhosphoSitePlus; Q9DAY5; -.
DR PaxDb; Q9DAY5; -.
DR PRIDE; Q9DAY5; -.
DR Antibodypedia; 49519; 63 antibodies from 11 providers.
DR Ensembl; ENSMUST00000052691; ENSMUSP00000093344; ENSMUSG00000050088.
DR Ensembl; ENSMUST00000164837; ENSMUSP00000125970; ENSMUSG00000050088.
DR Ensembl; ENSMUST00000174004; ENSMUSP00000133628; ENSMUSG00000050088.
DR GeneID; 67912; -.
DR KEGG; mmu:67912; -.
DR UCSC; uc008ang.1; mouse.
DR MGI; MGI:1915162; 1600012H06Rik.
DR VEuPathDB; HostDB:ENSMUSG00000050088; -.
DR eggNOG; ENOG502RXJP; Eukaryota.
DR GeneTree; ENSGT00390000018879; -.
DR HOGENOM; CLU_113576_1_0_1; -.
DR InParanoid; Q9DAY5; -.
DR OMA; ESIFWTI; -.
DR OrthoDB; 1394242at2759; -.
DR PhylomeDB; Q9DAY5; -.
DR TreeFam; TF331743; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 67912; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9DAY5; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9DAY5; protein.
DR Bgee; ENSMUSG00000050088; Expressed in urinary bladder urothelium and 247 other tissues.
DR Genevisible; Q9DAY5; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR InterPro; IPR031420; UPF0669.
DR PANTHER; PTHR31703; PTHR31703; 1.
DR Pfam; PF17065; UPF0669; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..185
FT /note="UPF0669 protein C6orf120 homolog"
FT /id="PRO_0000297664"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 185 AA; 20945 MW; 0E0D7391B22FD234 CRC64;
MATPWRRALL MILASQVVTL VKCLEDDDVP EEWLLLHVVQ GQIGAGNYSY LRLNHEGKII
LRMQSLRGDA DLYVSDSTPH PSFDDYELQS VTCGQDVVSI PAHFQRPVGI GIYGHPSHHE
SDFEMRVYYD RTVDQYPFGE AAYFTDPTGA SQQQAYAPEE AAQEEESVLW TILISILKLV
LEILF
