CF136_HUMAN
ID CF136_HUMAN Reviewed; 315 AA.
AC Q5SQH8; A9R9P9; F8VX15; Q5SU01; Q6ZSB7; Q8TB84;
DT 02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Uncharacterized protein C6orf136;
GN Name=C6orf136;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5SQH8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SQH8-2; Sequence=VSP_014618;
CC Name=3;
CC IsoId=Q5SQH8-3; Sequence=VSP_014619;
CC Name=4;
CC IsoId=Q5SQH8-4; Sequence=VSP_046640;
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DR EMBL; AK127564; BAC87037.1; -; mRNA.
DR EMBL; AL662798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL732442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL845353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX119957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX908728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016167; AAH16167.1; -; mRNA.
DR CCDS; CCDS43443.1; -. [Q5SQH8-1]
DR CCDS; CCDS4684.2; -. [Q5SQH8-3]
DR CCDS; CCDS54979.1; -. [Q5SQH8-4]
DR RefSeq; NP_001103408.1; NM_001109938.2. [Q5SQH8-1]
DR RefSeq; NP_659466.2; NM_145029.3. [Q5SQH8-3]
DR RefSeq; XP_011512686.1; XM_011514384.1. [Q5SQH8-2]
DR AlphaFoldDB; Q5SQH8; -.
DR BioGRID; 128738; 12.
DR IntAct; Q5SQH8; 2.
DR MINT; Q5SQH8; -.
DR STRING; 9606.ENSP00000293604; -.
DR iPTMnet; Q5SQH8; -.
DR PhosphoSitePlus; Q5SQH8; -.
DR BioMuta; C6orf136; -.
DR DMDM; 71658797; -.
DR EPD; Q5SQH8; -.
DR jPOST; Q5SQH8; -.
DR MassIVE; Q5SQH8; -.
DR MaxQB; Q5SQH8; -.
DR PaxDb; Q5SQH8; -.
DR PeptideAtlas; Q5SQH8; -.
DR PRIDE; Q5SQH8; -.
DR ProteomicsDB; 29053; -.
DR ProteomicsDB; 63798; -. [Q5SQH8-1]
DR ProteomicsDB; 63799; -. [Q5SQH8-2]
DR ProteomicsDB; 63800; -. [Q5SQH8-3]
DR Antibodypedia; 55864; 97 antibodies from 15 providers.
DR DNASU; 221545; -.
DR Ensembl; ENST00000293604.10; ENSP00000293604.6; ENSG00000204564.12. [Q5SQH8-4]
DR Ensembl; ENST00000376471.8; ENSP00000365654.4; ENSG00000204564.12. [Q5SQH8-3]
DR Ensembl; ENST00000376473.9; ENSP00000365656.5; ENSG00000204564.12. [Q5SQH8-1]
DR Ensembl; ENST00000383580.8; ENSP00000373074.4; ENSG00000206487.11. [Q5SQH8-3]
DR Ensembl; ENST00000383581.8; ENSP00000373075.4; ENSG00000206487.11. [Q5SQH8-1]
DR Ensembl; ENST00000415931.6; ENSP00000402805.2; ENSG00000233164.9. [Q5SQH8-3]
DR Ensembl; ENST00000417076.6; ENSP00000405594.2; ENSG00000237100.9. [Q5SQH8-3]
DR Ensembl; ENST00000417649.6; ENSP00000395979.2; ENSG00000233641.9. [Q5SQH8-3]
DR Ensembl; ENST00000419321.6; ENSP00000398769.2; ENSG00000237100.9. [Q5SQH8-1]
DR Ensembl; ENST00000422530.6; ENSP00000390275.2; ENSG00000237012.9. [Q5SQH8-1]
DR Ensembl; ENST00000425581.6; ENSP00000404588.2; ENSG00000233641.9. [Q5SQH8-1]
DR Ensembl; ENST00000430141.6; ENSP00000396916.2; ENSG00000224120.9. [Q5SQH8-1]
DR Ensembl; ENST00000447505.6; ENSP00000415915.2; ENSG00000233164.9. [Q5SQH8-1]
DR Ensembl; ENST00000455682.2; ENSP00000391657.2; ENSG00000224120.9. [Q5SQH8-3]
DR Ensembl; ENST00000456444.6; ENSP00000387592.2; ENSG00000237012.9. [Q5SQH8-3]
DR Ensembl; ENST00000651131.1; ENSP00000499201.1; ENSG00000204564.12. [Q5SQH8-4]
DR GeneID; 221545; -.
DR KEGG; hsa:221545; -.
DR MANE-Select; ENST00000651131.1; ENSP00000499201.1; NM_001161376.2; NP_001154848.1. [Q5SQH8-4]
DR UCSC; uc003nqw.5; human. [Q5SQH8-1]
DR CTD; 221545; -.
DR GeneCards; C6orf136; -.
DR HGNC; HGNC:21301; C6orf136.
DR HPA; ENSG00000204564; Low tissue specificity.
DR neXtProt; NX_Q5SQH8; -.
DR OpenTargets; ENSG00000204564; -.
DR PharmGKB; PA134962744; -.
DR VEuPathDB; HostDB:ENSG00000204564; -.
DR eggNOG; KOG4457; Eukaryota.
DR GeneTree; ENSGT00390000008658; -.
DR HOGENOM; CLU_555426_0_0_1; -.
DR InParanoid; Q5SQH8; -.
DR OMA; EHLAIMY; -.
DR PhylomeDB; Q5SQH8; -.
DR TreeFam; TF313961; -.
DR PathwayCommons; Q5SQH8; -.
DR SignaLink; Q5SQH8; -.
DR BioGRID-ORCS; 221545; 36 hits in 1071 CRISPR screens.
DR GenomeRNAi; 221545; -.
DR Pharos; Q5SQH8; Tdark.
DR PRO; PR:Q5SQH8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5SQH8; protein.
DR Bgee; ENSG00000204564; Expressed in mucosa of transverse colon and 95 other tissues.
DR ExpressionAtlas; Q5SQH8; baseline and differential.
DR Genevisible; Q5SQH8; HS.
DR InterPro; IPR018790; DUF2358.
DR PANTHER; PTHR31094; PTHR31094; 1.
DR Pfam; PF10184; DUF2358; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..315
FT /note="Uncharacterized protein C6orf136"
FT /id="PRO_0000089531"
FT VAR_SEQ 1..143
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014618"
FT VAR_SEQ 24
FT /note="Q -> QVSGGEEGGRRGGGERPSSKPVRGAERALGSAQAQRHPPPLPTCALQ
FT RVDRLGVAGAGGRRCRACRARTSVLPGLRAVRRGQGQAAGRVCVAPDSPRLPVPRGDLK
FT GRGREIRSPAAAPSRSSPAQTRPAGRPQQPARLALGERSWQEGRPVCTRFGPLRPGWQD
FT GHAPSRDGASRTPSGTE (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_046640"
FT VAR_SEQ 25..158
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_014619"
FT CONFLICT 187
FT /note="T -> S (in Ref. 1; BAC87037)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="H -> P (in Ref. 1; BAC87037)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 35794 MW; 01C9883DA956EB35 CRC64;
MYQPSRGAAR RLGPCLRAYQ ARPQDQLYPG TLPFPPLWPH STTTTSPSSP LFWSPLPPRL
PTQRLPQVPP LPLPQIQALS SAWVVLPPGK GEEGPGPELH SGCLDGLRSL FEGPPCPYPG
AWIPFQVPGT AHPSPATPSG DPSMEEHLSV MYERLRQELP KLFLQSHDYS LYSLDVEFIN
EILNIRTKGR TWYILSLTLC RFLAWNYFAH LRLEVLQLTR HPENWTLQAR WRLVGLPVHL
LFLRFYKRDK DEHYRTYDAY STFYLNSSGL ICRHRLDKLM PSHSPPTPVK KLLVGALVAL
GLSEPEPDLN LCSKP
